scholarly journals NR5A2 Promotes Cell Growth and Resistance to Temozolomide Through Regulating Notch Signal Pathway in Glioma

2020 ◽  
Vol Volume 13 ◽  
pp. 10231-10244
Author(s):  
Quanxi Yang ◽  
Lei Deng ◽  
Jialiang Li ◽  
Pengfei Miao ◽  
Wenxiang Liu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Signal Pathway ◽  
Notch Signal ◽  
Notch Signal Pathway

The effect of Notch signal pathway on PM2.5-induced Muc5ac in Beas-2B cells

2020 ◽  
Vol 203 ◽  
pp. 110956
Author(s):  
Ying Liu ◽  
Tong Zhou ◽  
Luyao Sun ◽  
Haodong Wang ◽  
Liting Zhou
Keyword(s):  
Signal Pathway ◽  
Notch Signal ◽  
Notch Signal Pathway

scholarly journals Thep53Family Member Genes Are Involved in the Notch Signal Pathway

2001 ◽  
Vol 277 (1) ◽  
pp. 719-724 ◽  
Author(s):  
Yasushi Sasaki ◽  
Setsuko Ishida ◽  
Ichiro Morimoto ◽  
Toshiharu Yamashita ◽  
Takashi Kojima ◽  
...  
Keyword(s):  
Signal Pathway ◽  
Notch Signal ◽  
Notch Signal Pathway

Notch signal pathway and tumor

2009 ◽  
Vol 28 (8) ◽  
pp. 975-978
Author(s):  
Jian LIU ◽  
Kui WANG ◽  
Feng SHEN
Keyword(s):  
Signal Pathway ◽  
Notch Signal ◽  
Notch Signal Pathway

scholarly journals Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

2015 ◽  
Vol 36 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Xiao Chen ◽  
Jiejie Cai ◽  
Xi Zhou ◽  
Lingzhi Chen ◽  
Yongsheng Gong ◽  
...  
Keyword(s):  
Western Blot ◽  
Protective Effect ◽  
Blot Analysis ◽  
Western Blot Analysis ◽  
Transforming Growth Factor ◽  
Signal Pathway ◽  
Mesenchymal Transition ◽  
Notch Signal ◽  
Endothelial To Mesenchymal Transition ◽  
Notch Signal Pathway

Background: Fibrosis results in excessive buildup of extracellular matrix proteins along with abnormalities in structure and is partly derived by a process involving transforming growth factor β (TGF-β) called endothelial-to-mesenchymal transition (EndMT). We investigated whether the aldosterone receptor-blocker spironolactone could abrogate TGF-β-induced fibrosis in EndMT and the underlying mechanism. Methods: Human umbilical vein endothelial cells (HUVECs) were divided into 5 groups for treatment: blank; vehicle control; TGF-β (10 ng/ml); spironolactone (1 μM)+TGF-β; and spironolactone+TGF-β+DAPT (10 μM). Cell chemotaxis was assayed by transwell assay. The expression of CD31 and vimentin was determined by Immunofluorescence staining and western blot analysis. Notch1 protein level was detected by western blot analysis. Results: Spironolactone significantly prevented TGF-β-stimulated EndMT by down-regulate vimentin and up-regulate CD31 in HUVECs (p<0.01).It inhibited cell migration during EndMT (p<0.01). The protective effect of spironolactone against EndMT could be attenuated by blocking the Notch signal pathway with DAPT (p<0.01). Notch signaling was activated and cross-interacted with TGF-β and spironolactone in regulating EndMT in HUVECs and reversed the spironolactone-related signaling by abrogating the antifibrotic actions with decreased Notch1 protein expression (p<0.01). Conclusion: Spironolactone may have a protective role in TGF-β-induced EndMT in HUVECs mediated by the Notch signal pathway.

scholarly journals Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury

Cell Cycle ◽  
2019 ◽  
Vol 18 (21) ◽  
pp. 3010-3029 ◽  
Author(s):  
Dingfei Qian ◽  
Linwei Li ◽  
Yuluo Rong ◽  
Wei Liu ◽  
Qian Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Signal Pathway ◽  
Notch Signal ◽  
Cord Injury ◽  
Notch Signal Pathway

Inhibition on Numb/Notch signal pathway enhances radiosensitivity of lung cancer cell line H358

Tumor Biology ◽  
2016 ◽  
Vol 37 (10) ◽  
pp. 13705-13719 ◽  
Author(s):  
Shi-Gang Song ◽  
Hong-Yang Yu ◽  
Yan-Wei Ma ◽  
Feng Zhang ◽  
Xiang-Ying Xu
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Signal Pathway ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Notch Signal ◽  
Notch Signal Pathway
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