scholarly journals Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression

2020 ◽  
Vol Volume 13 ◽  
pp. 2739-2745 ◽  
Author(s):  
Xiaojuan Lyu ◽  
Lin Zhou ◽  
Fengjuan Fan ◽  
Zhen Dong
Keyword(s):  
Microarray Analysis ◽  
Promoting Effect ◽  
Genome Wide ◽  
Novel Biomarkers ◽  
Glioma Progression

scholarly journals Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Jianye Xu ◽  
Jian Zhang ◽  
Zongpu Zhang ◽  
Zijie Gao ◽  
Yanhua Qi ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Autophagy Induction ◽  
Antitumor Immunotherapy ◽  
Novel Biomarkers ◽  
And Migration ◽  
Immunosuppressive Microenvironment ◽  
Proliferation And Migration ◽  
Glioma Progression

AbstractExosomes participate in intercellular communication and glioma microenvironment modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote the generation of the immunosuppressive microenvironment are still unclear. Here, we investigated the effects of GDEs on autophagy, the polarization of tumor-associated macrophages (TAMs), and glioma progression. Compared with normoxic glioma-derived exosomes (N-GDEs), hypoxic glioma-derived exosomes (H-GDEs) markedly facilitated autophagy and M2-like macrophage polarization, which subsequently promoted glioma proliferation and migration in vitro and in vivo. Western blot and qRT-PCR analyses indicated that interleukin 6 (IL-6) and miR-155-3p were highly expressed in H-GDEs. Further experiments showed that IL-6 and miR-155-3p induced M2-like macrophage polarization via the IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 positive feedback loop, which promotes glioma progression. Our study clarifies a mechanism by which hypoxia and glioma influence autophagy and M2-like macrophage polarization via exosomes, which could advance the formation of the immunosuppressive microenvironment. Our findings suggest that IL-6 and miR-155-3p may be novel biomarkers for diagnosing glioma and that treatments targeting autophagy and the STAT3 pathway may contribute to antitumor immunotherapy.

Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK

2002 ◽  
Vol 43 (5) ◽  
pp. 1331-1345 ◽  
Author(s):  
Randy M. Berka ◽  
Jeanette Hahn ◽  
Mark Albano ◽  
Irena Draskovic ◽  
Marjan Persuh ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Microarray Analysis ◽  
Genome Wide ◽  
Genome Wide Expression

Abstract 3012: Genome-wide analysis of CpG island methylation in bladder cancer identifies novel biomarkers for diagnosis, prediction of progression and survival

2011 ◽  
Author(s):  
Raju Kandimalla ◽  
Angela A. G. van Tilborg ◽  
Lucie C. Kompier ◽  
Dominique J.P.M. Stumpel ◽  
Chris H. Bangma ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cpg Island ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Novel Biomarkers ◽  
Cpg Island Methylation
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