scholarly journals CDK4/6 Inhibitor Palbociclib Amplifies the Radiosensitivity to Nasopharyngeal Carcinoma Cells via Mediating Apoptosis and Suppressing DNA Damage Repair

2019 ◽  
Vol Volume 12 ◽  
pp. 11107-11117 ◽  
Author(s):  
Xianhe Xie ◽  
Weili Zheng ◽  
Ting Chen ◽  
Wanzun Lin ◽  
Ziyuan Liao ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nasopharyngeal Carcinoma ◽  
Dna Damage Repair ◽  
Carcinoma Cells ◽  
Damage Repair

scholarly journals Metformin inhibits the growth of nasopharyngeal carcinoma cells and sensitizes the cells to radiation via inhibition of the DNA damage repair pathway

2014 ◽  
Vol 32 (6) ◽  
pp. 2596-2604 ◽  
Author(s):  
HAIWEN LI ◽  
XINGGUI CHEN ◽  
YING YU ◽  
ZHENNAN WANG ◽  
YUFANG ZUO ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nasopharyngeal Carcinoma ◽  
Dna Damage Repair ◽  
Carcinoma Cells ◽  
Repair Pathway ◽  
Damage Repair

scholarly journals VEGF knockdown enhances radiosensitivity of nasopharyngeal carcinoma by inhibiting autophagy through the activation of mTOR pathway

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Li Chen ◽  
Guoxiang Lin ◽  
Kaihua Chen ◽  
Fangzhu Wan ◽  
Renba Liang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nasopharyngeal Carcinoma ◽  
Western Blotting ◽  
Dna Damage Repair ◽  
Xenograft Model ◽  
Mtor Pathway ◽  
Angiogenic Factor ◽  
Cell Counting ◽  
Damage Repair

Abstract Vascular endothelial growth factor (VEGF) is an important pro-angiogenic factor. VEGF was reported to promote the occurrence of autophagy, which enhanced the radioresistance of tumors. The purpose of this study was to investigate the influence of VEGF silencing on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the underlying mechanisms. The radiosensitivity of NPC cells after VEGF silencing was detected by cell counting kit 8 (CCK-8) and clonogenic assay, while cell cycle and apoptosis were detected by flow cytometry. The processes of DNA damage, repair and autophagy were examined by immunofluorescence and western blotting. The interaction between VEGF and mTOR was confirmed by western blotting and co-immunoprecipitation studies. The effect of VEGF on radiosensitivity of NPC cells was investigated in vivo using a xenograft model. Furthermore, immunohistochemistry and TUNEL assays were used to verify the relationship between autophagy and radiosensitivity in NPC after VEGF depletion. Downregulation of VEGF significantly inhibited cell proliferation and induced apoptosis of NPC cells after radiotherapy in vitro and in vivo. In addition, VEGF knockdown not only decreased autophagy level, but also delayed the DNA damage repair in NPC cells after irradiation. Mechanistically, silencing VEGF suppressed autophagy through activation of the mTOR pathway. VEGF depletion increased radiosensitivity of NPC cells by suppressing autophagy via activation of the mTOR pathway.

scholarly journals CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma

2020 ◽  
Vol 123 ◽  
pp. 109748 ◽  
Author(s):  
Muping Di ◽  
Meng Wang ◽  
Jingjing Miao ◽  
Boyu Chen ◽  
Huageng Huang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nasopharyngeal Carcinoma ◽  
Dna Damage Repair ◽  
Damage Repair

scholarly journals Erlotinib enhanced chemoradiotherapy sensitivity via inhibiting DNA damage repair in nasopharyngeal carcinoma CNE2 cells

2020 ◽  
Vol 9 (5) ◽  
pp. 2559-2567
Author(s):  
Yunxia Zhang ◽  
Fang Zhou ◽  
Jian Zhang ◽  
Qinzhou Zou ◽  
Qiang Fan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nasopharyngeal Carcinoma ◽  
Dna Damage Repair ◽  
Damage Repair

366-OR: TCF19 Promotes Functional Beta-Cell Mass and Proliferative Capacity by Regulating DNA Damage Repair Pathways

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 366-OR
Author(s):  
GRACE H. YANG ◽  
JEE YOUNG HAN ◽  
SUKANYA LODH ◽  
JOSEPH T. BLUMER ◽  
DANIELLE FONTAINE ◽  
...  
Keyword(s):  
Dna Damage ◽  
Beta Cell ◽  
Dna Damage Repair ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Proliferative Capacity ◽  
Damage Repair ◽  
Repair Pathways
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