scholarly journals FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation

2020 ◽  
Vol Volume 13 ◽  
pp. 1461-1470 ◽  
Author(s):  
Yudi Ding ◽  
Nana Qi ◽  
Ke Wang ◽  
Yiming Huang ◽  
Jinling Liao ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lung Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Cell Progression

scholarly journals CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion

2021 ◽  
Vol 567 ◽  
pp. 222-229
Author(s):  
Yiliang Meng ◽  
Liu Yang ◽  
Xiao Wei ◽  
Hongcheng Luo ◽  
Yingying Hu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lung Adenocarcinoma ◽  
Cyclin D1 ◽  
Migration And Invasion ◽  
Adenocarcinoma Cell ◽  
Cell Migration And Invasion

PIM2 promotes lung adenocarcinoma cell migration by regulating XIAP/NF-κB pathway

2021 ◽  
Keyword(s):  
Cell Migration ◽  
Western Blot ◽  
Lung Adenocarcinoma ◽  
Cell Viability ◽  
Adenocarcinoma Cell ◽  
Invasion And Migration ◽  
Over Expression ◽  
Apoptosis Protein ◽  
Iκbα Phosphorylation ◽  
And Migration

Background and objective: Proviral insertion site in Moloney murine leukemia virus (PIM)2 functions as a serine/threonine kinase to participate in regulating cell proliferation and cell cycle. PIM2 has been shown to be elevated in the lung cancer cell lines. This study was performed to investigate the role of PIM2 in lung adenocarcinoma cell growth. Mateial and methods: Expression level of PIM2 in lung adenocarcinoma tissues and cells was detected by qRT-PCR (quantitative Reverse Transcription PCR) and western blot. The over-expression and knockdown of PIM2 were separately established by employing pcDNA and siRNA to explore the effects on the cell viability, apoptosis, invasion and migration. The downstream pathways were evaluated by western blot assay. Results: Lung adenocarcinoma tissues and cells showed an elevation of both PIM2 mRNA and protein expression. Knocking down PIM2 decreased the cell viability and promoted the apoptosis, which can be reversed by pcDNA-mediated over-expression of PIM2. PIM2 silencing suppressed the promotional effect of over-expression of PIM2 on cell invasion and migration through increasing IκBα expression and decreasing the X-linked inhibitor of apoptosis protein (XIAP), p65 and IκBα phosphorylation. While, over-expression of PIM2 showed opposite effect on IκBα and XIAP expression or p65 and IκBα phosphorylation. Conclusion: PIM2 can not only suppress lung adenocarcinoma cell apoptosis but also promote cell migration and invasion depending on XIAP/NF-κB signaling pathway.

scholarly journals FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14

Cell Cycle ◽  
2019 ◽  
Vol 18 (21) ◽  
pp. 2972-2985 ◽  
Author(s):  
Guodong Xiao ◽  
Peili Wang ◽  
Xiaoqiang Zheng ◽  
Dapeng Liu ◽  
Xin Sun
Keyword(s):  
Cell Migration ◽  
Lung Adenocarcinoma ◽  
Migration And Invasion ◽  
Adenocarcinoma Cell ◽  
Cell Migration And Invasion

Selective COX-2 Blockade Inhibits Lung Adenocarcinoma Cell Migration in vitro

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 731S
Author(s):  
Leah M. Backhus ◽  
Eric M. Sievers ◽  
Robert D. Bart ◽  
Vaughn A. Starnes ◽  
Ross M. Bremner ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lung Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Cox 2

scholarly journals Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Edit Kiss ◽  
El Husseiny Mohamed Mahmud Abdelwahab ◽  
Anita Steib ◽  
Emoke Papp ◽  
Zsofia Torok ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lung Adenocarcinoma ◽  
Interleukin 6 ◽  
Dependent Manner ◽  
Adenocarcinoma Cell ◽  
Oncogenic Mutation
Sign in / Sign up

Export Citation Format

Share Document