scholarly journals Long Noncoding RNA X-Inactive Specific Transcript Facilitates Cellular Functions in Melanoma via miR-139-5p/ROCK1 Pathway

2020 ◽  
Vol Volume 13 ◽  
pp. 1277-1287 ◽  
Author(s):  
Ke Tian ◽  
Dongxia Sun ◽  
Min Chen ◽  
Yifei Yang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cellular Functions ◽  
Specific Transcript

scholarly journals Long Noncoding RNA X-Inactive Specific Transcript Facilitates Cellular Functions in Melanoma via miR-139-5p/ROCK1 Pathway [Retraction]

2021 ◽  
Vol Volume 14 ◽  
pp. 4999-5000
Author(s):  
Ke Tian ◽  
Dongxia Sun ◽  
Min Chen ◽  
Yifei Yang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cellular Functions ◽  
Specific Transcript

The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers

Tumor Biology ◽  
2015 ◽  
Vol 37 (2) ◽  
pp. 1437-1444 ◽  
Author(s):  
Chenhui Ma ◽  
Xuefei Shi ◽  
Qingqing Zhu ◽  
Qian Li ◽  
Yafang Liu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Growth Arrest ◽  
Specific Transcript ◽  
Human Cancers

scholarly journals The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer

2020 ◽  
Vol 17 (9) ◽  
pp. 1187-1195
Author(s):  
Shun-Long Weng ◽  
Soo-Cheen Ng ◽  
Yueh‐Chun Lee ◽  
Yi-Hsuan Hsiao ◽  
Chun-Fang Hsu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Polymorphisms ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Growth Arrest ◽  
Uterine Cervical Cancer ◽  
Specific Transcript

X-inactive-specific transcript: A long noncoding RNA with complex roles in human cancers

Gene ◽  
2018 ◽  
Vol 679 ◽  
pp. 28-35 ◽  
Author(s):  
Zhi Yang ◽  
Xiaodi Jiang ◽  
Xiaofeng Jiang ◽  
Haiying Zhao
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Specific Transcript ◽  
Human Cancers

scholarly journals Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating Nuclear Factor of Activated T cell 5 Expression

2021 ◽  
Vol 12 ◽  
Author(s):  
Mengqi Zhang ◽  
Haojun Yang ◽  
Zhuohui Chen ◽  
Xinhang Hu ◽  
Tong Wu ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Protein Level ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Luciferase Reporter ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nuclear Factor ◽  
Xist Expression ◽  
Astrocyte Activation ◽  
Specific Transcript

BackgroundAstrocyte activation promotes glutamate accumulation and secretion of inflammatory factors, mainly responsible for epilepsy. Long noncoding RNA (lncRNA) X-inactive-specific transcript (XIST) regulates inflammation; however, the biological role and regulatory mechanism of XIST during astrocyte activation remain unclear.MethodsIn the present study, rat epilepsy model and lipopolysaccharide (LPS)-treated CTX-TNA2 were established. XIST and miR-29c-3p expression were evaluated using quantitative real-time polymerase chain reaction. Nuclear factor of activated T cells 5 (NFAT5) was measured using western blot analysis. Interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and L-glutamate levels in the culture supernatants were assessed using enzyme-linked immunosorbent assay. The binding between XIST and miR-29c-3p and between miR-29c-3p and the 3′-UTR of NFAT5 was analyzed using dual-luciferase reporter, RNA-binding protein immunoprecipitation (RIP), and Biotin pull-down assay. The proliferation and apoptosis were evaluated using CCK8 and flow cytometry, respectively.ResultsXIST expression and NFAT5 protein level was increased, whereas miR-29c-3p expression was decreased in the epilepsy rat model and LPS-treated CTX-TNA2 cells. Silenced XIST expression, miR-29c-3p overexpression, or silenced NFAT5 expression inhibited the secretion of IL-1β, IL-6, and TNF-α and promoted glutamate transport in LPS-treated CTX-TNA2 cells. miR-29c-3p was the potential miRNA sponged by XIST. NFAT5 acted as a direct binding target of miR-29c-3p. Silenced miR-29c-3p expression or NFAT5 overexpression reversed the effect of silenced XIST expression on LPS-treated CTX-TNA2.XIST and miR-29c-3p treatment does not affect NFAT5 mRNA expression, but affects NFAT5 protein level. Furthermore, underexpressed XIST or overexpressed miR-29c-3p in LPS-stimulated CTX-TNA2 can attenuate neuronal apoptosis induced by LPS-stimulated CTX-TNA2.ConclusionLncRNA XIST promotes the secretion of inflammatory cytokines in LPS- treated CTX-TNA2 via sponging miR-29c-3p and regulating NFAT5 expression.

scholarly journals Long noncoding RNA X-inactive specific transcript as a prognostic factor in cancer patients

Medicine ◽  
2019 ◽  
Vol 98 (3) ◽  
pp. e14095 ◽  
Author(s):  
Jinbo Chen ◽  
Xiong Yang ◽  
Dongkui Gong ◽  
Yu Cui ◽  
Jiao Hu ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Cancer Patients ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Specific Transcript
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