scholarly journals The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma

2019 ◽  
Vol Volume 12 ◽  
pp. 7725-7735 ◽  
Author(s):  
Lin-ang Wang ◽  
Bo Yang ◽  
Wen Rao ◽  
Hualiang Xiao ◽  
Dong Wang ◽  
...  
Keyword(s):  
T Cell ◽  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
Cd8 T Cell ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract

Evaluation of the Prognostic Significance of Altered Mammalian Target of Rapamycin Pathway Biomarkers in Upper Tract Urothelial Carcinoma

Urology ◽  
2014 ◽  
Vol 84 (5) ◽  
pp. 1134-1140 ◽  
Author(s):  
Aditya Bagrodia ◽  
Laura-Maria Krabbe ◽  
Bishoy A. Gayed ◽  
Payal Kapur ◽  
Ira Bernstein ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Mammalian Target Of Rapamycin ◽  
Prognostic Significance ◽  
Upper Tract Urothelial Carcinoma ◽  
Target Of Rapamycin ◽  
Upper Tract

899 IMMUNOEXPRESSION STATUS AND PROGNOSTIC SIGNIFICANCE OF MTOR PATHWAY MEMBERS IN UPPER TRACT UROTHELIAL CARCINOMA

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Kazutoshi Fujita ◽  
Sheila Faraj ◽  
Enrico Munari ◽  
Alcides Chaux ◽  
Nilda Gonzalez-Roibon ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
Mtor Pathway ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract

MP71-05 PROGNOSTIC SIGNIFICANCE OF BAP1 EXPRESSION IN UPPER TRACT UROTHELIAL CARCINOMA

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Nirmish Singla ◽  
Ahmet Aydin ◽  
Vandana Panwar ◽  
Ryan Hutchinson ◽  
Solomon Woldu ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract

The expression and clinical significance of PD-L1 in patients with upper tract urothelial carcinoma.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 444-444
Author(s):  
Xinan Sheng ◽  
Zhisong He ◽  
Yan Kong ◽  
Zhihong Chi ◽  
Lu Si ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Urothelial Carcinoma ◽  
Tumor Staging ◽  
Prognostic Significance ◽  
Upper Tract Urothelial Carcinoma ◽  
Tumor Cell Membrane ◽  
Upper Tract ◽  
Bladder Urothelial Carcinoma ◽  
N Classification

444 Background: Primary upper tract urothelial carcinoma (UTUC) is rare. In China UTUCs are more common than in Western populations and account for 20–30% of all TCCs.An antibody that targets programmed death ligand-1 (PD-L1) pathway has been shown to be active towards various types of cancer including bladder urothelial carcinoma. In this study, we investigated the PD-L1 expression and prognostic significance in UTUC. Methods: Formalin-fixed paraffin-embedded tumor samples from 78 patients with upper tract urothelial carcinoma from Peking University Cancer Hospital and Peking Universiy First Hospital were retrieved. PD-L1 expression was evaluated by immunohistochemistry using rabbit monoclonal anti-PD-L1 antibody. PD-L1 positivity on tumor cell membrane was defined as ≥ 1% of tumor cell membrane staining.The clinical data of patients were retrospective collected. The multivariate analysis was used to assess the association of PD-L1 expressionwith tumor staging, pathological N classification, whether firstly diagnosed with metastasis, disease free survival(DFS) and overall survival (OS) in patients. Results: The positive rates of PD-L1 expression were 42.3% (33/78) for upper tract urothelial carcinoma. Sex,location, pathological tumor staging, pathological N classification, whether firstly diagnosed with metastasis did not correlate with PD-L1 expression. In patients with upper tract UC, PD-L1 expression was not associated with DFS and OS on univariate analyses. Conclusions: To our knowledge, this is first study about PD-L1 expression in UTUC patients. In this study, We found the PD-L1 expression in UTUC was higher than in the bladder urothelial carcinoma. It means anti-PD-L1 treatment may be better for advanced UTUC. There was no correlation between PD-L1 expression and outcome.

Upper tract urothelial carcinoma is non-basal and T-cell depleted.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 4525-4525 ◽  
Author(s):  
Panagiotis J. Vlachostergios ◽  
Brian D. Robinson ◽  
Bhavneet Bhinder ◽  
Rohan Bareja ◽  
Kyung Park ◽  
...  
Keyword(s):  
T Cell ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract

scholarly journals Prognostic significance of sarcopenia in upper tract urothelial carcinoma patients treated with radical nephroureterectomy

2016 ◽  
Vol 5 (9) ◽  
pp. 2213-2220 ◽  
Author(s):  
Hiroshi Fukushima ◽  
Yasukazu Nakanishi ◽  
Madoka Kataoka ◽  
Ken‐ichi Tobisu ◽  
Fumitaka Koga
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Upper Tract

scholarly journals The prognostic significance of inflammation-associated blood cell markers in patients with upper tract urothelial carcinoma

2016 ◽  
Vol 27 (2) ◽  
pp. S1-S2
Author(s):  
Hsin-Chih Yeh ◽  
Wen-Jeng Wu ◽  
Ching-Chia Li ◽  
Chun-Nung Huang ◽  
Hung-Lung Ke ◽  
...  
Keyword(s):  
Blood Cell ◽  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
Upper Tract Urothelial Carcinoma ◽  
Cell Markers ◽  
Upper Tract
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