scholarly journals EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo

2019 ◽  
Vol Volume 12 ◽  
pp. 8915-8933
Author(s):  
Ning Kang ◽  
Jijun Zhou ◽  
Jia Xu ◽  
Dongsheng Zhou ◽  
Weichen Shi
Keyword(s):  
Breast Cancer ◽  
Cancer Invasion ◽  
Invasion And Metastasis ◽  
Breast Cancer Invasion

scholarly journals A Src/Abl Kinase Inhibitor, SKI-606, Blocks Breast Cancer Invasion, Growth, and Metastasis In vitro and In vivo

2007 ◽  
Vol 67 (4) ◽  
pp. 1580-1588 ◽  
Author(s):  
Houda Jallal ◽  
Maria-Luisa Valentino ◽  
Gaoping Chen ◽  
Frank Boschelli ◽  
Suhad Ali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Kinase Inhibitor ◽  
Cancer Invasion ◽  
Abl Kinase ◽  
Breast Cancer Invasion

scholarly journals P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1459
Author(s):  
Jan-Hendrik Venhuizen ◽  
Paul Span ◽  
Koen van den Dries ◽  
Sebastian Sommer ◽  
Peter Friedl ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Invasion ◽  
Breast Cancer Patients ◽  
Invasion And Metastasis ◽  
P120 Catenin ◽  
Growth And Survival ◽  
Exon Expression ◽  
Breast Cancer Invasion ◽  
Specific Regulation

Tumor metastasis is the endpoint of tumor progression and depends on the ability of tumor cells to locally invade tissue, transit through the bloodstream and ultimately to colonize secondary organs at distant sites. P120 catenin (p120) has been implicated as an important regulator of metastatic dissemination because of its roles in cell–cell junctional stability, cytoskeletal dynamics, growth and survival. However, conflicting roles for p120 in different tumor models and steps of metastasis have been reported, and the understanding of p120 functions is confounded by the differential expression of p120 isoforms, which differ in N-terminal length, tissue localization and, likely, function. Here, we used in silico exon expression analyses, in vitro invasion assays and both RT-PCR and immunofluorescence of human tumors. We show that alternative exon usage favors expression of short isoform p120-3 in 1098 breast tumors and correlates with poor prognosis. P120-3 is upregulated at the invasive front of breast cancer cells migrating as collective groups in vitro. Furthermore, we demonstrate in histological sections of 54 human breast cancer patients that p120-3 expression is maintained throughout the metastatic cascade, whereas p120-1 is differentially expressed and diminished during invasion and in metastases. These data suggest specific regulation and functions of p120-3 in breast cancer invasion and metastasis.

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