scholarly journals Comparison of the diagnostic performance of fluorescence in situ hybridization (FISH), nuclear matrix protein 22 (NMP22), and their combination model in bladder carcinoma detection: a systematic review and meta-analysis

2018 ◽  
Vol Volume 12 ◽  
pp. 349-358 ◽  
Author(s):  
Qindong Liang ◽  
Guangjie Zhang ◽  
Wuxian Li ◽  
Jing Wang ◽  
Shangchun Sheng
Keyword(s):  
Systematic Review ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Nuclear Matrix ◽  
Bladder Carcinoma ◽  
Diagnostic Performance ◽  
Matrix Protein ◽  
Meta Analysis ◽  
Nuclear Matrix Protein

Diagnostic accuracy of NMP-52, NMP-22 and urine cytology in the diagnosis of bladder cancer

2021 ◽  
Vol 16 (10) ◽  
pp. 59-62
Author(s):  
Mohamed J. Saadh
Keyword(s):  
Bladder Cancer ◽  
Nuclear Matrix ◽  
Diagnostic Performance ◽  
Matrix Protein ◽  
Urinary Cytology ◽  
Significant Relation ◽  
Nuclear Matrix Protein ◽  
Diagnostic Efficacy ◽  
Noninvasive Biomarkers ◽  
New Biomarkers

Bladder cancer (BC) is the most important tumor problem of urologic cancer. Therefore, noninvasive urinary biomarkers were used for diagnosis of BC. However, the new biomarkers failed to reach higher accuracy. The aim of this study was to assess the diagnostic efficacy of nuclear matrix protein-22 (NMP- 22), nuclear matrix protein-52 (NMP-52), urinary cytology and to investigate combinations of urine NMP-52 with urinary cytology as noninvasive biomarkers to increase diagnostic performance of bladder cancer at different grades and stages. Overall, there were 156 subjects (62 BC, 54 cystitis patients and 40 healthy volunteers). The NMP-22 and NMP-52 were quantified in urine samples by ELISA. The urinary cytology is used by some physicians routinely for diagnosis of BC. The sensitivity and specificity for NMP-52 were 94% and 82%, for NMP-22 69% and 80.8% and for cytology 56% and 94.6% respectively and also, both urinary NMP-22 and NMP-52 have extremely significant relation (p<0.0001) to BC vs. healthy individuals and cystitis patients. Moreover, the combination of NMP- 52 with urinary cytology could predict all BC stages and grade with 95.6% sensitivity and 94.3% specificity. In conclusion, NMP-52 and urinary cytology in combination improve diagnostic performance for BC detection in different pathological types.

Detection of genetic alterations in primary bladder carcinoma with dual-color and multiplex fluorescence in situ hybridization

2004 ◽  
Vol 149 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Maria I. Stamouli ◽  
Anna D. Panani ◽  
Angeliki D. Ferti ◽  
Constantina Petraki ◽  
R.T.D. Oliver ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Bladder Carcinoma ◽  
Genetic Alterations ◽  
Dual Color ◽  
Primary Bladder
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