scholarly journals Natural antisense transcript of hypoxia-inducible factor 1 regulates hypoxic cell apoptosis in epithelial ovarian cancer

2018 ◽  
Vol Volume 11 ◽  
pp. 9101-9110 ◽  
Author(s):  
Jun-jun Qiu ◽  
Xiao-jing Lin ◽  
Ting-ting Zheng ◽  
Xiao-yan Tang ◽  
Ke-qin Hua
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cell Apoptosis ◽  
Antisense Transcript ◽  
Hypoxia Inducible Factor ◽  
Hypoxic Cell ◽  
Natural Antisense Transcript ◽  
Hypoxia Inducible Factor 1

Low dosage of arsenic trioxide (As2O3) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis

2018 ◽  
Vol 23 (6) ◽  
pp. 939-947 ◽  
Author(s):  
Dehong Luo ◽  
Xiaoyuan Zhang ◽  
Renle Du ◽  
Wenjuan Gao ◽  
Na Luo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Arsenic Trioxide ◽  
Cell Apoptosis ◽  
Low Dosage

scholarly journals Expression of hypoxia-inducible factor 1α gene affects the outcome in patients with ovarian cancer

2008 ◽  
Vol 18 (3) ◽  
pp. 499-505 ◽  
Author(s):  
R. SHIMOGAI ◽  
J. KIGAWA ◽  
H. ITAMOCHI ◽  
T. IBA ◽  
Y. KANAMORI ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Hypoxia Inducible Factor ◽  
Disease Free Survival ◽  
High Expression ◽  
Vegf Expression ◽  
Free Survival ◽  
Hypoxia Inducible Factor 1Α ◽  
Disease Free ◽  
Low Expression

We conducted study to determine whether and how the expression of the hypoxia-inducible factor 1α (HIF-1α) gene relates to outcome in patients with epithelial ovarian cancer. A total of 66 patients with epithelial ovarian cancer, who underwent primary surgery followed by platinum-based chemotherapy, were entered into this study. We confirmed the expression of HIF-1α and the vascular endothelial growth factor (VEGF) by immunohistochemistry. To determine the quantity of HIF-1α and VEGF expression, messenger RNA of each gene was measured by real-time reverse transcription–polymerase chain reaction. The cutoff values were determined by the receiver-operating characteristic curve according to survival. The protein expressions of HIF-1α and VEGF were strongly observed in the cancer cells. The cutoff value of HIF-1α and VEGF gene expression was 6.0 and 3.0, respectively. The expression of HIF-1α did not relate to clinical stage, but tumor with low VEGF expression was observed more frequently in stage I patients. The response rate to chemotherapy did not differ between high and low expression of both genes. The overall survival for patients with high expression of HIF-1α was significantly lower, but disease-free survival did not differ between high and low expression of HIF-1α, whereas both overall and disease-free survival for patients with high expression of VEGF were significantly lower. Multivariate analysis revealed that FIGO stage and HIF-1α expression were independent prognostic factors but that VEGF was not. The present study suggested that the expression level of HIF-1α could be an independent prognostic factor in epithelial ovarian cancer

Serum antibodies recognizing hypoxia-inducible factor 1-alpha and platinum sensitivity in ovarian cancer

2014 ◽  
Vol 133 ◽  
pp. 71-72
Author(s):  
M.D. Dao ◽  
K.J. Agnew ◽  
E.M. Swisher ◽  
B.A. Goff ◽  
M.L. Disis ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Hypoxia Inducible Factor ◽  
Serum Antibodies ◽  
Platinum Sensitivity ◽  
Hypoxia Inducible Factor 1

scholarly journals Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 22650-22664 ◽  
Author(s):  
Natividad Gomez-Roman ◽  
Neha Mohan Sahasrabudhe ◽  
Fiona McGregor ◽  
Anthony J. Chalmers ◽  
Jim Cassidy ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Hypoxia Inducible Factor ◽  
Aggressive Phenotype ◽  
Hypoxia Inducible Factor 1
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