scholarly journals SRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer

2018 ◽  
Vol Volume 11 ◽  
pp. 5359-5370 ◽  
Author(s):  
Nan Yi ◽  
Mingbing Xiao ◽  
Feng Jiang ◽  
Zhaoxiu Liu ◽  
Wenkai Ni ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Therapeutic Target ◽  
Prognostic Indicator ◽  
Human Colorectal Cancer ◽  
Potential Therapeutic Target ◽  
Poor Prognostic Indicator

Wild-type IDH2 protects nuclear DNA from oxidative damage and is a potential therapeutic target in colorectal cancer

Oncogene ◽  
2021 ◽  
Author(s):  
Shuang Qiao ◽  
Wenhua Lu ◽  
Christophe Glorieux ◽  
Jiangjiang Li ◽  
Peiting Zeng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Oxidative Damage ◽  
Therapeutic Target ◽  
Nuclear Dna ◽  
Wild Type ◽  
Potential Therapeutic Target

scholarly journals ITGB4 as a novel serum diagnosis biomarker and potential therapeutic target for colorectal cancer

2021 ◽  
Author(s):  
Xia Jiang ◽  
Jia Wang ◽  
Mengyu Wang ◽  
Mingda Xuan ◽  
Shuangshuang Han ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

Evaluation of MACF1-regulatory non-coding RNA as a potential therapeutic target in Colorectal Cancer

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Rowaida Mohammed Reda M. M Aboushahba ◽  
Fayda Ibrahim Abdel Motaleb ◽  
Ahmed Abdel Aziz Abou-Zeid ◽  
Enas Samir Nabil ◽  
Dalia Abdel-Wahab Mohamed ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Wnt Signaling ◽  
Cell Line ◽  
Signaling Pathway ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Wnt Signaling Pathway ◽  
Control Group ◽  
Potential Therapeutic Target

ABSTRACT Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths world-wide. There is an increasing need for the identification of novel biomarkers/targets for early diagnosis and for the development of novel chemopreventive and therapeutic agents for CRC. Recently, MACF1 gene has emerged as a potential therapeutic target in cancer as it involved in processes critical for tumor cell proliferation, invasion and metastasis. It is suggested that MACF1 may function in cancers through Wnt signaling. MiR-34a is a well-known tumor suppressor miRNA.miR-34a targets MACF1 gene as a part of the wnt signaling pathway. In this study, 40 colonic tissues were collected from CRC patients (20) and control subjects (20). miR-34a-5p was assessed by real time PCR in all study groups. The results showed highly significant decrease (P < 0.01) in miR-34a relative expression in the CRC group (median RQ 0.13) when compared to the benign group (median RQ 5.3) and the healthy control group (median RQ 19.63). miR-34a mimic and inhibitor were transfected in CaCo-2 cell line and proliferation was assessed. The transfection of the cell line with miR-34a mimic decreased cell proliferation. Our study suggests that miR-34a-5p targets MACF1 gene as a part of the wnt signaling pathway leading to the involvement in the molecular mechanisms of CRC development and progression.

The 9p21 locus as a potential therapeutic target and prognostic marker in colorectal cancer

2018 ◽  
Vol 19 (5) ◽  
pp. 463-474 ◽  
Author(s):  
Afsane Bahrami ◽  
Seyed Mahdi Hassanian ◽  
Majid Khazaei ◽  
Masoumeh Gharib ◽  
Mahsa Rahmani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
9P21 Locus

PGC-1 expression level in human colorectal cancer: A predictor of lymph node metastasis

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 3616-3616
Author(s):  
H. Kwon ◽  
S. Shin ◽  
M. S. Roh ◽  
H. J. Choi ◽  
J. Kwak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Prognostic Indicator ◽  
Nodal Metastasis ◽  
Published Data ◽  
Peroxisome Proliferator ◽  
Human Colorectal Cancer ◽  
Peroxisome Proliferator Activated Receptor ◽  
Age At Surgery ◽  
Depth Of Infiltration

3616 Background: Previous study showed that the expression of peroxisome proliferator-activated receptor γ (PPARγ) and PPARγ coactivator-1 (PGC-1) was correlated with clinical outcome in breast cancer. However, no published data are available about the biological and clinical significance of PGC-1 in colorectal cancer. Thus, our aim was to explore the expression of PPARγ and PGC-1 in colorectal cancer as well as their association with other clinicopathological features, and to evaluate the role of PPARγ and PGC-1 as a prognostic indicator of colorectal cancer. Methods: We have investigated the presence of PPARγ and PGC-1 in human colorectal cancer tissues and adjacent normal tissues from 108 primary colorectal cancer patients by immunohistochemistry. The correlation between their expression and clinicopathologic features was investigated. Three-year overall survival of patients with different expression of PPARγ and PGC-1 were analyzed by the Kaplan-Meier method. Results: No significant correlation was found between PPARγ expression and age at surgery, gender, histopathologic differentiation, depth of infiltration, relapse, and Dukes’ stage. No significant correlation was found between PGC-1 expression and age at surgery, the histopathologic differentiation, the depth of infiltration, and relapse. However, PGC-1 expression was closely related to Duke’s stage and nodal metastasis (p=0.024 and p=0.020, respectively). Survival analysis showed that the PGC-1-positive group has a reduced overall survival (p=0.0367). Conclusions: Based on our results, PGC-1 may be valuable marker of nodal metastasis and represent a biomarker of poor prognosis in colorectal cancer. No significant financial relationships to disclose.

scholarly journals Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer

2017 ◽  
Vol 23 (14) ◽  
pp. 3918-3928 ◽  
Author(s):  
Wenhao Weng ◽  
Qing Wei ◽  
Shusuke Toden ◽  
Kazuhiro Yoshida ◽  
Takeshi Nagasaka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Therapeutic Target ◽  
Prognostic Biomarker ◽  
Circular Rna ◽  
Potential Therapeutic Target

scholarly journals The role of Reg IV in colorectal cancer, as a potential therapeutic target

2015 ◽  
Vol 4 ◽  
pp. 261-264
Author(s):  
Yiwang Hu ◽  
Chi Pan ◽  
Jiyi Hu ◽  
Suzhan Zhang
Keyword(s):  
Colorectal Cancer ◽  
Therapeutic Target ◽  
Potential Therapeutic Target
Sign in / Sign up

Export Citation Format

Share Document