scholarly journals Overexpression of CLEC3A promotes tumor progression and poor prognosis in breast invasive ductal cancer

2018 ◽  
Vol Volume 11 ◽  
pp. 3303-3312 ◽  
Author(s):  
Jun Ni ◽  
Yun Peng ◽  
Fu-Lan Yang ◽  
Xun Xi ◽  
Xing-Wei Huang ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Poor Prognosis ◽  
Invasive Ductal Cancer ◽  
Ductal Cancer

scholarly journals Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

2021 ◽  
Vol 9 (1) ◽  
pp. e001341
Author(s):  
Chunxiao Li ◽  
Xiaofei Xu ◽  
Shuhua Wei ◽  
Ping Jiang ◽  
Lixiang Xue ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Poor Prognosis ◽  
Tumor Immunotherapy ◽  
Therapeutic Strategies ◽  
Preclinical Studies ◽  
Future Prospects ◽  
Tumor Associated Macrophages

Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies have identified important pathways regulating the infiltration and polarization of TAMs during tumor progression. Furthermore, potential therapeutic strategies targeting TAMs in tumors have been studied, including inhibition of macrophage recruitment to tumors, functional repolarization of TAMs toward an antitumor phenotype, and other therapeutic strategies that elicit macrophage-mediated extracellular phagocytosis and intracellular destruction of cancer cells. Therefore, with the increasing impact of tumor immunotherapy, new antitumor strategies to target TAMs are now being discussed.

scholarly journals Hypoxia and the Tumor Microenvironment

2021 ◽  
Vol 20 ◽  
pp. 153303382110363
Author(s):  
Yue Li ◽  
Long Zhao ◽  
Xiao-Feng Li
Keyword(s):  
Immune Response ◽  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Tumor Biology ◽  
Metastatic Potential ◽  
Tumor Detection ◽  
Tumor Aggressiveness

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

scholarly journals OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (24) ◽  
pp. 36681-36697 ◽  
Author(s):  
Yiqin Wang ◽  
Xianrong Zhou ◽  
Midie Xu ◽  
Weiwei Weng ◽  
Qiongyan Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Progression ◽  
Poor Prognosis

Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma

2019 ◽  
Vol 86 ◽  
pp. 233-242 ◽  
Author(s):  
Yixuan Wang ◽  
Junjie Piao ◽  
Qianrong Wang ◽  
Xuelian Cui ◽  
Ziqi Meng ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Gsk 3Β

scholarly journals Increased Argonaute 2 Expression in Gliomas and its Association with Tumor Progression and Poor Prognosis

2014 ◽  
Vol 15 (9) ◽  
pp. 4079-4083 ◽  
Author(s):  
Bo Feng ◽  
Peng Hu ◽  
Shu-Jun Lu ◽  
Jin-Bo Chen ◽  
Ru-Li Ge
Keyword(s):  
Tumor Progression ◽  
Poor Prognosis ◽  
Argonaute 2

scholarly journals Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33586-33600 ◽  
Author(s):  
Xiao-Lu Lin ◽  
Li Yang ◽  
Seng-Wang Fu ◽  
Wen-Feng Lin ◽  
Yun-Jie Gao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Human Colorectal Cancer

Overexpression of UQCRC2 is correlated with tumor progression and poor prognosis in colorectal cancer

2018 ◽  
Vol 214 (10) ◽  
pp. 1613-1620 ◽  
Author(s):  
Yuanyuan Shang ◽  
Fang Zhang ◽  
Dehui Li ◽  
Chang Li ◽  
Hongbo Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Progression ◽  
Poor Prognosis
Sign in / Sign up

Export Citation Format

Share Document