scholarly journals Forecast of actin-binding proteins as the oncotarget in osteosarcoma – a review of mechanism, diagnosis and therapy

2018 ◽  
Vol Volume 11 ◽  
pp. 1553-1561 ◽  
Author(s):  
Yucheng Fu ◽  
Wei Yu ◽  
Hongliu Cai ◽  
Anwei Lu
Keyword(s):  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins ◽  
Diagnosis And Therapy

scholarly journals Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yu-Gui Zhang ◽  
Jiang-Tao Niu ◽  
Hong-Wei Wu ◽  
Xin-Lei Si ◽  
Shu-Juan Zhang ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Cancer Diagnosis ◽  
Binding Proteins ◽  
Inflammatory Diseases ◽  
Actin Binding ◽  
Actin Binding Proteins ◽  
Abnormal Expression ◽  
Diagnosis And Therapy ◽  
Cancer Diagnosis And Therapy ◽  
Potential Biomarkers

Actin-binding proteins (ABPs), by interacting with actin, regulate the polymerization, depolymerization, bundling, and cross-linking of actin filaments, directly or indirectly, thereby mediating the maintenance of cell morphology, cell movement, and many other biological functions. Consequently, these functions of ABPs help regulate cancer cell invasion and metastasis when cancer occurs. In recent years, a variety of ABPs have been found to be abnormally expressed in various cancers, indicating that the detection and interventions of unusual ABP expression to alter this are available for the treatment of cancer. The early stages of most cancer development involve long-term chronic inflammation or repeated stimulation. This is the case for breast cancer, gastric cancer, lung cancer, prostate cancer, liver cancer, esophageal cancer, pancreatic cancer, melanoma, and colorectal cancer. This article discusses the relationship between chronic inflammation and the above-mentioned cancers, emphatically introduces relevant research on the abnormal expression of ABPs in chronic inflammatory diseases, and reviews research on the expression of different ABPs in the above-mentioned cancers. Furthermore, there is a close relationship between ABP-induced inflammation and cancer. In simple terms, abnormal expression of ABPs contributes to the chronic inflammation developing into cancer. Finally, we provide our viewpoint regarding these unusual ABPs serving as potential biomarkers for chronic inflammation-induced cancer diagnosis and therapy, and interventions to reverse the abnormal expression of ABPs represent a potential approach to preventing or treating the corresponding cancers.

Actin-binding proteins sensitively mediate actin bundle stiffness

2006 ◽  
Vol 39 ◽  
pp. S240
Author(s):  
M. Bathe ◽  
M. Claessens ◽  
E. Frey ◽  
A. Bausch
Keyword(s):  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins ◽  
Actin Bundle

A review of actin binding proteins: new perspectives

2007 ◽  
Vol 36 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Ricardo Uribe ◽  
David Jay
Keyword(s):  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins

scholarly journals Actin-Binding Proteins Mediate Regulation by Calcium of Polycystin-2 (tRPP2)

2011 ◽  
Vol 100 (3) ◽  
pp. 106a-107a
Author(s):  
María del Rocío Cantero ◽  
Horacio F. Cantiello
Keyword(s):  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins

Viscoelastic Properties of F-Actin Solutions in the Presence of Normal and Mutated Actin-Binding Proteins

1996 ◽  
Vol 325 (2) ◽  
pp. 183-189 ◽  
Author(s):  
K.-P. Janssen ◽  
L. Eichinger ◽  
P.A. Janmey ◽  
A.A. Noegel ◽  
M. Schliwa ◽  
...  
Keyword(s):  
Viscoelastic Properties ◽  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins

Actin-binding proteins are conserved from slime molds to man

1988 ◽  
Vol 9 (4-5) ◽  
pp. 521-530 ◽  
Author(s):  
Michael Schleicher ◽  
Elisabeth André ◽  
Herbert Hartmann ◽  
Angelika A. Noegel
Keyword(s):  
Binding Proteins ◽  
Actin Binding ◽  
Actin Binding Proteins ◽  
Slime Molds

scholarly journals Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane.

1994 ◽  
Vol 125 (2) ◽  
pp. 381-391 ◽  
Author(s):  
J Mulholland ◽  
D Preuss ◽  
A Moon ◽  
A Wong ◽  
D Drubin ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Actin Cytoskeleton ◽  
Binding Proteins ◽  
Ultrastructural Level ◽  
Actin Binding ◽  
Cortical Actin ◽  
Actin Binding Proteins ◽  
Double Labeling ◽  
Wall Growth ◽  
Cortical Cytoskeleton

We characterized the yeast actin cytoskeleton at the ultrastructural level using immunoelectron microscopy. Anti-actin antibodies primarily labeled dense, patchlike cortical structures and cytoplasmic cables. This localization recapitulates results obtained with immunofluorescence light microscopy, but at much higher resolution. Immuno-EM double-labeling experiments were conducted with antibodies to actin together with antibodies to the actin binding proteins Abp1p and cofilin. As expected from immunofluorescence experiments, Abp1p, cofilin, and actin colocalized in immuno-EM to the dense patchlike structures but not to the cables. In this way, we can unambiguously identify the patches as the cortical actin cytoskeleton. The cortical actin patches were observed to be associated with the cell surface via an invagination of plasma membrane. This novel cortical cytoskeleton-plasma membrane interface appears to consist of a fingerlike invagination of plasma membrane around which actin filaments and actin binding proteins are organized. We propose a possible role for this unique cortical structure in wall growth and osmotic regulation.

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