scholarly journals Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms

2018 ◽  
Vol Volume 11 ◽  
pp. 8937-8942 ◽  
Author(s):  
Ethan B. Ludmir ◽  
Tyler Gutschenritter ◽  
Chelsea C. Pinnix ◽  
Jillian R. Gunther ◽  
Loretta J. Nastoupil ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Molecular Mechanisms ◽  
Case Series ◽  
Stromal Tumor ◽  
Primary Breast Lymphoma ◽  
Breast Lymphoma

Ovarian Cancer Metastases Mimicking Gastrointestinal Stromal Tumor: A Case Series

2016 ◽  
Vol 111 ◽  
pp. S1109-S1110
Author(s):  
Umar Hayat ◽  
Ari Garber ◽  
Bradley Confer ◽  
Tyler Stevens ◽  
John Vargo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gastrointestinal Stromal Tumor ◽  
Case Series ◽  
Stromal Tumor ◽  
Cancer Metastases

scholarly journals A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis): case series of 28 patients

2012 ◽  
Vol 23 (5) ◽  
pp. 1335-1340 ◽  
Author(s):  
A.G. Dumont ◽  
L. Rink ◽  
A.K. Godwin ◽  
M. Miettinen ◽  
H. Joensuu ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Desmoid Tumor ◽  
Case Series ◽  
Stromal Tumor ◽  
Deep Fibromatosis

scholarly journals Hepatectomy for liver metastasis from gastrointestinal stromal tumor in the era of imatinib mesylate: a case series study

2017 ◽  
Vol 6 (3) ◽  
pp. 121-125
Author(s):  
Norio Kawamura ◽  
Toshiya Kamiyama ◽  
Hideki Yokoo ◽  
Tatsuhiko Kakisaka ◽  
Tatsuya Orimo ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Gastrointestinal Stromal Tumor ◽  
Imatinib Mesylate ◽  
Case Series ◽  
Stromal Tumor ◽  
Case Series Study ◽  
Series Study

scholarly journals A nonrandom association of sarcoidosis in patients with gastrointestinal stromal tumor and other sarcomas

Rare Tumors ◽  
2018 ◽  
Vol 10 ◽  
pp. 203636131878762 ◽  
Author(s):  
Andrea P Espejo ◽  
Jeremy L Ramdial ◽  
Breelyn A Wilky ◽  
Darcy A Kerr ◽  
Jonathan C Trent
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Catchment Area ◽  
Case Series ◽  
Epithelioid Cell ◽  
The State ◽  
Stromal Tumor ◽  
Cancer Prognosis ◽  
Uterine Leiomyosarcoma ◽  
Imaging Features ◽  
Standardized Incidence Ratio

In patients with sarcoma, concomitant malignancy is found in 1.2% -2.5% of cases. Previous studies have demonstrated conflicting results in terms of positive or negative effects on cancer prognosis with comorbid sarcoidosis. Additionally, there are no data determining whether an association between sarcoidosis and sarcomas exists. Finding an association between the two entities could prevent inadvertent upstaging of a primary sarcoma based on pulmonary nodularity mistaken for metastatic disease. Here, we will describe eight sarcoma patients with concomitant occurrence of sarcoidosis identified since 2007. Eight patients with diagnosis of both sarcoma and sarcoidosis were identified over the period of 2007 -2016 at a single sarcoma center. Clinical and historical data including presentation, histology, treatment, and outcome was tabulated for analysis. The standardized incidence ratio was calculated for the state of Florida and our hospital catchment area. We compared the observed incidence to the expected incidence if the two entities were to be unrelated. Sarcoma subtype was gastrointestinal stromal tumor in five patients, the remaining three cases were unclassified spindled and epithelioid cell sarcoma, uterine leiomyosarcoma, and myxofibrosarcoma. Sarcoidosis was diagnosed before sarcoma in three patients, after sarcoma in four patients, and at the same time of sarcoma diagnosis in one patient. From our series, three patients have shown no progression of sarcoma, two are alive with sarcoma, two died due to progression of sarcoma, and one was lost to follow up. Statistical analyses showed a standardized incidence ratio of 305 (95% confidence interval: 131 -556) for the state of Florida and standardized incidence ratio of 950 (95% CI: 407 -1727) for our catchment area. This case series points to a statistically robust, nonrandom association between sarcoma and sarcoidosis that has not been previously described. Presumed metastatic sarcoma should be considered for biopsy particularly with demographic characteristics or imaging features suggestive of sarcoidosis.

Coexistence of gastrointestinal stromal tumor (GIST) with desmoid tumor (DT): Case series of 22 patients.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 10052-10052
Author(s):  
A. G. Dumont ◽  
L. Rink ◽  
M. Miettinen ◽  
H. Joensuu ◽  
J. R. Strosberg ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Desmoid Tumor ◽  
Case Series ◽  
Stromal Tumor

scholarly journals Avapritinib in advanced gastrointestinal stromal tumor: case series and review of the literature from a tertiary care center in India

2021 ◽  
pp. FSO676
Author(s):  
Saurav Verma ◽  
Rohit Reddy ◽  
Sheragaru Hanumanthappa Chandrashekhara ◽  
Shamim Ahmed Shamim ◽  
Sarthak Tripathy ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Clinical Benefit ◽  
Care Center ◽  
Tertiary Care ◽  
Case Series ◽  
Progression Free Survival ◽  
Response Assessment ◽  
Stromal Tumor ◽  
Significant Difference ◽  
Us Fda

The therapeutic landscape in advanced gastrointestinal stromal tumor has evolved. Avapritinib and ripretinib have now been approved by the US FDA for platelet-derived growth factor alpha D842V-mutant and refractory gastrointestinal stromal tumor patients, respectively. Here we report five patients who have been on avapritinib under an expanded access program. Response assessment was available for four patients – a partial response in two patients and stable disease in one, while one patient had progressive disease. Though preliminary results of the VOYAGER trial have shown less activity of avapritinib and no significant difference in progression-free survival when compared with regorafenib, avapritinib may show some clinical benefit in a subset of patients refractory to approved therapies. We share our experience of five cases, with clinical benefit in three. We believe avapritinib should be further evaluated in clinical trials.

Sign in / Sign up

Export Citation Format

Share Document