scholarly journals Prognostic value of circulating tumor cells detected with the CellSearch System in patients with gastric cancer: evidence from a meta-analysis

2018 ◽  
Vol Volume 11 ◽  
pp. 1013-1023 ◽  
Author(s):  
Chaogang Yang ◽  
Kun Zou ◽  
Zewei Yuan ◽  
Tangxi Guo ◽  
Bin Xiong
Keyword(s):  
Gastric Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Cellsearch System

scholarly journals Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Xuanzhang Huang ◽  
Peng Gao ◽  
Yongxi Song ◽  
Jingxu Sun ◽  
Xiaowan Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Cellsearch System

Detecting circulating tumor cells (CTCs) in patients with high-risk, localized prostate cancer using the CellSearch platform.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15178-e15178
Author(s):  
Sumanta Kumar Pal ◽  
Clayton Lau ◽  
Miaoling He ◽  
Przemyslaw Twardowski ◽  
Timothy G. Wilson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Gleason Score ◽  
Prognostic Value ◽  
Localized Prostate Cancer ◽  
Cellsearch System ◽  
Mesenchymal Transition ◽  
E Cadherin

e15178 Background: Enumeration of circulating tumor cells (CTCs) using the CellSearch platform has prognostic value in patients with metastatic castration resistant prostate cancer. However, the prognostic value of CTC enumeration in high-risk, localized prostate cancer (HRLPC) remains undefined. Methods: Patients with HRLPC (defined by ≥1 of the following criteria: ≥ cT3a disease, Gleason score 8-10, or PSA > 20 ng/mL) who have chosen prostatectomy for their definitive management were prospectively identified. Patients were consented to receive 4 sequential 30 mL blood draws, each collected in 3 separate 10 mL EDTA tubes. The first 2 blood draws were conducted 2 weeks prior and immediately prior to surgery, while the second 2 blood draws were conducted 4-6 weeks and 3 months following surgery. Within 4 hrs of blood collection, the white blood cell (WBC) fraction was pooled and Ficoll purified. The WBC fraction was transferred to a CellSave tube, and CTCs were enumerated using the CellSearch system. Expression of CD133 and E-cadherin was characterized using the CellSearch system in patients with detectable CTCs. Results: Within 3 monthsof study initiation in Nov 2011, 19 of a planned 37 patients have been accrued. Median age in the cohort was 65 (range, 51-74), and the number of patients with Gleason score 8-10, ≥ cT3a disease, or PSA > 20 ng/mL was 16, 4, and 2, respectively. The majority of patients (17/19, or 89%) had only one high-risk feature. Mean baseline PSA for the cohort was 11.4 (range, 3.4-37). CTCs were detectable in 67% of patients prior to surgery, 27% of patients at 1 month following surgery and 67% of patients at 3 months following surgery. Amongst those patients with detectable CTCs, the median count was 3 (range, 1-7). Further, in these patients, CD133 and E-cadherin were detected in 44% and 46% of specimens assessed, respectively. Full details of these analyses will be provided at the time of the meeting. Conclusions: Using a modified methodology, CTC enumeration using the CellSearch platform is feasible in patients with HRLPC. Interestingly, markers of epithelial-mesenchymal transition and stem cell lineage are detectable in a proportion of patients with localized disease.

Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer

2012 ◽  
Vol 18 (20) ◽  
pp. 5701-5710 ◽  
Author(s):  
Liling Zhang ◽  
Sabine Riethdorf ◽  
Gang Wu ◽  
Tao Wang ◽  
Kunyu Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Prognostic Value ◽  
Meta Analysis

scholarly journals The Prognostic Value of Circulating Tumor Cells in Patients with Melanoma: A Systematic Review and Meta-analysis

2006 ◽  
Vol 12 (15) ◽  
pp. 4605-4613 ◽  
Author(s):  
Simone Mocellin ◽  
Dave Hoon ◽  
Alessandro Ambrosi ◽  
Donato Nitti ◽  
Carlo Riccardo Rossi
Keyword(s):  
Systematic Review ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Prognostic Value ◽  
Meta Analysis
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