scholarly journals RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1

2017 ◽  
Vol Volume 10 ◽  
pp. 2609-2619 ◽  
Author(s):  
Dapeng Yu ◽  
Chao Zhang ◽  
Junqing Gui
Keyword(s):  
Bladder Cancer ◽  
Cancer Progression ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

INVESTIGATION OF THE ROLE OF GRSF-1 RNA BINDING PROTEIN IN PROSTATE CANCER PROGRESSION

1999 ◽  
pp. 61
Author(s):  
Michael E. Chen ◽  
Gail C. Fraizer ◽  
Tasneem Ahmed ◽  
Bei Zheng ◽  
Jeffrey Wilusz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Prostate Cancer Progression

scholarly journals Identification of the Six-RNA-Binding Protein Signature for Prognosis Prediction in Bladder Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Yucai Wu ◽  
Yi Liu ◽  
Anbang He ◽  
Bao Guan ◽  
Shiming He ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Prognosis Prediction ◽  
Protein Signature

scholarly journals Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

2013 ◽  
Vol 14 (5) ◽  
pp. 10015-10041 ◽  
Author(s):  
Jun Wang ◽  
Yan Guo ◽  
Huili Chu ◽  
Yaping Guan ◽  
Jingwang Bi ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Multiple Functions ◽  
Treatment Responses

scholarly journals Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Sakari Vanharanta ◽  
Christina B Marney ◽  
Weiping Shu ◽  
Manuel Valiente ◽  
Yilong Zou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Wnt Signaling Pathway ◽  
Experimental Models ◽  
Breast Cancer Progression ◽  
Binding Motif ◽  
Clinical Breast

The mechanisms through which cancer cells lock in altered transcriptional programs in support of metastasis remain largely unknown. Through integrative analysis of clinical breast cancer gene expression datasets, cell line models of breast cancer progression, and mutation data from cancer genome resequencing studies, we identified RNA binding motif protein 47 (RBM47) as a suppressor of breast cancer progression and metastasis. RBM47 inhibited breast cancer re-initiation and growth in experimental models. Transcriptome-wide HITS-CLIP analysis revealed widespread RBM47 binding to mRNAs, most prominently in introns and 3′UTRs. RBM47 altered splicing and abundance of a subset of its target mRNAs. Some of the mRNAs stabilized by RBM47, as exemplified by dickkopf WNT signaling pathway inhibitor 1, inhibit tumor progression downstream of RBM47. Our work identifies RBM47 as an RNA-binding protein that can suppress breast cancer progression and demonstrates how the inactivation of a broadly targeted RNA chaperone enables selection of a pro-metastatic state.

scholarly journals hnRNPA2B1-Mediated Extracellular Vesicles Sorting of miR-122-5p Potentially Promotes Lung Cancer Progression

2021 ◽  
Vol 22 (23) ◽  
pp. 12866
Author(s):  
Chuang Li ◽  
Fang Qin ◽  
Wei Wang ◽  
Yifan Ni ◽  
Mingyu Gao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Tumor Metastasis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Small Cell ◽  
Small Cell Lung ◽  
Non Coding Rna

Extracellular vesicles (EVs) released by tumor cells play important roles on the remodeling of the tumor–stromal environment and on promoting tumor metastasis. Our earlier studies revealed that miR-122-5p, a type of small non-coding RNA, was dysregulated in non-small cell lung cancer (NSCLC) cell-derived EVs. In this study, we found that miR-122-5p was selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1. In addition, we found that hnRNPA2B1 interacted with miR-122-5p through the EXO-motif. The delivering of lung cancer EVs-miR-122-5p promoted the migration of liver cells, which may play roles in establishing a pre-metastatic micro-environment and hepatic metastasis of lung cancer. Importantly, our findings revealed the molecular mechanism that RNA-binding protein controls the selective sorting of tumor-derived EV miR-122-5p, which potentially promotes lung cancer progression.

scholarly journals RNA‐binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression

2020 ◽  
Vol 111 (2) ◽  
pp. 369-382
Author(s):  
Jing Zhao ◽  
Yu Zhang ◽  
Xi‐sheng Liu ◽  
Fang‐ming Zhu ◽  
Feng Xie ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Progression ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Prostate Cancer Progression

scholarly journals The RNA-binding protein ESRP1 promotes human colorectal cancer progression

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 10007-10024 ◽  
Author(s):  
Sharmila Fagoonee ◽  
Gabriele Picco ◽  
Francesca Orso ◽  
Arrigo Arrigoni ◽  
Dario L. Longo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Progression
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