scholarly journals Knockdown of a DIS3L2 promoter upstream long noncoding RNA (AC105461.1) enhances colorectal cancer stem cell properties in vitro by down-regulating DIS3L2

2017 ◽  
Vol Volume 10 ◽  
pp. 2367-2376 ◽  
Author(s):  
Wei Liu ◽  
Qiang Yu ◽  
Jun Ma ◽  
Yong Cheng ◽  
Hongbo Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals The Long Noncoding RNA HOTAIR Promotes Colorectal Cancer Progression by Sponging miR-197

2018 ◽  
Vol 26 (3) ◽  
pp. 473-481 ◽  
Author(s):  
Xinyang Lu ◽  
Zhiqiang Liu ◽  
Xiaofei Ning ◽  
Lunhua Huang ◽  
Biao Jiang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Migration And Invasion ◽  
Downstream Target ◽  
Potential Applications ◽  
Colorectal Cancer Progression

The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been found to be overexpressed in many human malignancies and involved in tumor progression and metastasis. Although the downstream target through which HOTAIR modulates tumor metastasis is not well known, evidence suggests that microRNA-197 (miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in the progression of colorectal cancer was detected in vitro and in vivo. We found that HOTAIR expression was significantly increased in colorectal cancer cells and tissues. In contrast, the expression of miR-197 was obviously decreased. We further demonstrated that HOTAIR knockdown promoted apoptosis and inhibited cell proliferation, migration, and invasion in vitro and in vivo. Moreover, HOTAIR modulated the progression of colorectal cancer by competitively binding miR-197. Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of colorectal cancer.

scholarly journals Long noncoding RNA n339260 promotes vasculogenic mimicry and cancer stem cell development in hepatocellular carcinoma

2018 ◽  
Vol 109 (10) ◽  
pp. 3197-3208 ◽  
Author(s):  
Xiulan Zhao ◽  
Baocun Sun ◽  
Tieju Liu ◽  
Bing Shao ◽  
Ran Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Vasculogenic Mimicry ◽  
Cell Development

scholarly journals Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Cell-Like Properties of Liver Cancer by Inhibiting CAMTA1

2016 ◽  
Vol 17 (10) ◽  
pp. 1617 ◽  
Author(s):  
Li-Juan Ding ◽  
Yan Li ◽  
Shu-Dong Wang ◽  
Xin-Sen Wang ◽  
Fang Fang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Cancer ◽  
Cancer Stem Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP

2021 ◽  
Vol 118 (29) ◽  
pp. e2026813118
Author(s):  
Yajie Chen ◽  
Qian Hao ◽  
Shanshan Wang ◽  
Mingming Cao ◽  
Yingdan Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Parp Inhibitors ◽  
Parp Inhibition ◽  
Mitochondrial Rna ◽  
Tumor Resistance ◽  
Factor C

p53 inactivation is highly associated with tumorigenesis and drug resistance. Here, we identify a long noncoding RNA, the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP), as an inhibitor of p53. RMRP is overexpressed and associated with an unfavorable prognosis in colorectal cancer. Ectopic RMRP suppresses p53 activity by promoting MDM2-induced p53 ubiquitination and degradation, while depletion of RMRP activates the p53 pathway. RMRP also promotes colorectal cancer growth and proliferation in a p53-dependent fashion in vitro and in vivo. This anti-p53 action of RMRP is executed through an identified partner protein, SNRPA1. RMRP can interact with SNRPA1 and sequester it in the nucleus, consequently blocking its lysosomal proteolysis via chaperone-mediated autophagy. The nuclear SNRPA1 then interacts with p53 and enhances MDM2-induced proteasomal degradation of p53. Remarkably, ablation of SNRPA1 completely abrogates RMRP regulation of p53 and tumor cell growth, indicating that SNRPA1 is indispensable for the anti-p53 function of RMRP. Interestingly and significantly, poly (ADP-ribose) polymerase (PARP) inhibitors induce RMRP expression through the transcription factor C/EBPβ, and RMRP confers tumor resistance to PARP inhibition by preventing p53 activation. Altogether, our study demonstrates that RMRP plays an oncogenic role by inactivating p53 via SNRPA1 in colorectal cancer.

In vitro derivation and characterization of a colorectal cancer stem cell subpopulation

2013 ◽  
Vol 7 (4) ◽  
pp. 320-324 ◽  
Author(s):  
A. P. Davydov-Sinitsyn ◽  
O. V. Bazhenova ◽  
M. A. Liskovykh ◽  
L. L. Chechik ◽  
S. V. Ponomartsev ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Subpopulation

Long Noncoding RNA ROR Regulates Proliferation, Invasion, and Stemness of Gastric Cancer Stem Cell

2016 ◽  
Vol 18 (5) ◽  
pp. 319-326 ◽  
Author(s):  
Shuai Wang ◽  
Feng Liu ◽  
Junji Deng ◽  
Xinsheng Cai ◽  
Junqing Han ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna
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