scholarly journals WWC3 downregulation correlates with poor prognosis and inhibition of Hippo signaling in human gastric cancer

2017 ◽  
Vol Volume 10 ◽  
pp. 2931-2942 ◽  
Author(s):  
Jiabin Hou ◽  
Jin Zhou
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Human Gastric Cancer ◽  
Hippo Signaling

scholarly journals MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway

2020 ◽  
Vol 217 (6) ◽  
Author(s):  
Liwei An ◽  
Pingping Nie ◽  
Min Chen ◽  
Yang Tang ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Poor Prognosis ◽  
Human Gastric Cancer ◽  
Hippo Signaling ◽  
Wild Type ◽  
Hippo Signaling Pathway ◽  
Phosphorylation Level ◽  
Signaling Axis ◽  
Importin Α

Hyperactivation of YAP has been commonly associated with tumorigenesis, and emerging evidence hints at multilayered Hippo-independent regulations of YAP. In this study, we identified a new MST4–YAP axis, which acts as a noncanonical Hippo signaling pathway that limits stress-induced YAP activation. MST4 kinase directly phosphorylated YAP at Thr83 to block its binding with importin α, therefore leading to YAP cytoplasmic retention and inactivation. Due to a consequential interplay between MST4-mediated YAP phospho-Thr83 signaling and the classical YAP phospho-Ser127 signaling, the phosphorylation level of YAP at Thr83 was correlated to that at Ser127. Mutation of T83E mimicking MST4-mediated alternative signaling restrained the activity of both wild-type YAP and its S127A mutant mimicking loss of classical Hippo signal. Depletion of MST4 in mice promoted gastric tumorigenesis with diminished Thr83 phosphorylation and hyperactivation of YAP. Moreover, loss of MST4–YAP signaling was associated with poor prognosis of human gastric cancer. Collectively, our study uncovered a noncanonical MST4–YAP signaling axis essential for suppressing gastric tumorigenesis.

WASF3 is associated with tumour invasiveness and confers a poor prognosis in human gastric cancer

2018 ◽  
Vol 7 (2) ◽  
pp. 353-362
Author(s):  
Ying Hu ◽  
Guo An ◽  
Yi-Qiang Liu ◽  
Yi-Xue Wang ◽  
Li-Jie Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Human Gastric Cancer

scholarly journals Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Wenjing Shang ◽  
Zhongdong Xie ◽  
Fengying Lu ◽  
Daoquan Fang ◽  
Tianbin Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Migration And Invasion ◽  
Human Gastric Cancer ◽  
Antitumor Effects ◽  
Thioredoxin 1

Background. Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes. Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear. Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC. Methods. We analyzed Trx-1 mRNA expression from the GEO database and Trx-1 protein expression in 144 GC tissues using immunohistochemistry. Effects of Trx-1 on GC cell were assessed in vitro and in vivo through Trx-1 knockdown or overexpression. The antitumor effects of the Trx-1 inhibitor, PX-12, on GC cells were investigated. PTEN and p-AKT expressions were evaluated by Western blotting. Results. Increased Trx-1 expression was found in GC tissues and associated with poor prognosis and aggressive clinicopathological characteristics in patients with GC. High Trx-1 expression predicted poor prognosis, and its expression was an independent prognostic factor for overall survival of GC patients. Knockdown of Trx-1 expression inhibited GC cell growth, migration, and invasion in vitro and tumor growth and lung metastasis in vivo. Conversely, overexpression of Trx-1 promoted GC cell growth, migration, and invasion. We also found that PX-12 inhibited GC cell growth, migration, and invasion. Overexpression of Trx-1 caused a decrease in PTEN and increase in p-AKT levels whereas silencing Trx-1 caused an increase in PTEN and decrease in p-AKT levels in GC cells. Inhibition of AKT signaling pathway by MK2206 also inhibited GC cell growth, migration, and invasion. Conclusion. Our results indicate that Trx-1 may be a promising prognostic indicator and therapeutic target for GC patients.

WD40 repeat-containing 62 overexpression as a novel indicator of poor prognosis for human gastric cancer

2013 ◽  
Vol 49 (17) ◽  
pp. 3752-3762 ◽  
Author(s):  
Shan Zeng ◽  
Yiming Tao ◽  
Jinlin Huang ◽  
Sai Zhang ◽  
Liangfang Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Human Gastric Cancer ◽  
Wd40 Repeat

Activated Pak4 expression correlates with poor prognosis in human gastric cancer patients

Tumor Biology ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 9431-9436 ◽  
Author(s):  
Danni Li ◽  
Ye Zhang ◽  
Zhi Li ◽  
Ximing Wang ◽  
Xiujuan Qu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Human Gastric Cancer ◽  
Gastric Cancer Patients

Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer

2012 ◽  
Vol 90 (9) ◽  
pp. 1037-1046 ◽  
Author(s):  
Hua Xiong ◽  
Wan Du ◽  
Ji-Lin Wang ◽  
Ying-Chao Wang ◽  
Jie-Ting Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Human Gastric Cancer ◽  
Constitutive Activation

HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer

2017 ◽  
Vol 471 (6) ◽  
pp. 743-751 ◽  
Author(s):  
Hao Xu ◽  
Zhi-Feng Miao ◽  
Zhen-Ning Wang ◽  
Ting-Ting Zhao ◽  
Ying-Ying Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Akt Pathway ◽  
Human Gastric Cancer

Overexpression of SPAG9 in human gastric cancer is correlated with poor prognosis

2015 ◽  
Vol 467 (5) ◽  
pp. 525-533 ◽  
Author(s):  
Zhi-Feng Miao ◽  
Zhen-Ning Wang ◽  
Ting-Ting Zhao ◽  
Ying-Ying Xu ◽  
Jian-Hua Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Human Gastric Cancer

scholarly journals Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Lujun Chen ◽  
Jun Feng ◽  
Shaoxian Wu ◽  
Bin Xu ◽  
You Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Invasion ◽  
Poor Prognosis ◽  
Human Gastric Cancer

scholarly journals Effects of the Hippo Signaling Pathway in Human Gastric Cancer

2013 ◽  
Vol 14 (9) ◽  
pp. 5199-5205 ◽  
Author(s):  
Guang-Xi Zhou ◽  
Xiao-Yu Li ◽  
Qi Zhang ◽  
Kun Zhao ◽  
Cui-Ping Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Human Gastric Cancer ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway
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