scholarly journals Antihormonal treatment associated musculoskeletal pain in women with breast cancer in the adjuvant setting

2016 ◽  
Vol Volume 9 ◽  
pp. 4929-4935 ◽  
Author(s):  
Selcuk Seber ◽  
Dilek Solmaz ◽  
Tarkan Yetisyigit
Keyword(s):  
Breast Cancer ◽  
Musculoskeletal Pain ◽  
Adjuvant Setting ◽  
Antihormonal Treatment

scholarly journals Taxane therapy in the adjuvant treatment of breast cancer in Italy: economic evaluation

2006 ◽  
Vol 7 (1) ◽  
pp. 63-69
Author(s):  
Simona Ravera ◽  
Lorenzo G. Mantovani
Keyword(s):  
Breast Cancer ◽  
Cost Minimization ◽  
Disease Free Survival ◽  
Developed Countries ◽  
Preventive Therapy ◽  
Point Of View ◽  
Adjuvant Setting ◽  
Screening Programs ◽  
Equivalent Efficacy ◽  
Dosing Regimens

Breast cancer (BC) is one of the leading cause of death in developed Countries and every year more than a million new cases are diagnosed worldwide. In Italy the prevalence of BC was estimated to be 1,070 per 100,000 at 31 December 1992. Nevertheless, despite the increase in incidence, mortality rate for BC are decreased in the last decades probably due to several factors such as implementation of screening programs, early diagnosis and new adjuvant therapies. Important types of adjuvant chemotherapy include anthracyclines and taxanes and these treatments continue to be evaluated to determine optimal combinations and dosing regimens. The efficacy of paclitaxel and docetaxel in adjuvant setting for the treatment of early BC has been assessed in different trials where the two taxanes showed a significant increase in both Disease Free Survival (DFS) and Overall Survival (OS) in comparison with nontaxane therapy. In particular results from one of the last studies comparing paclitaxel and docetaxel show equivalent efficacy for both drugs. At the light of the recent findings, the objective of this work is to perform a cost minimization analysis of paclitaxel vs docetaxel in the adjuvant setting for treatment of early BC in Italy. The analysis was conducted from the National Health Service’s point of view, assuming equivalent efficacy in terms of DFS and OS for both taxanes. Costs were evaluated on the basis of therapeutic schemes used in the analyzed trials. Results show that paclitaxel, administered every 3 weeks for 4 cycles after doxorubicin and cyclophosphamide, represents the less costly therapy. This is a conservative costs estimate based on data from literature that does not take into account possible additional costs associated to the treatment of febrile neutropenia (FN) as adverse event related to chemotherapy. Since, on the basis of scientific literature data, FN seems to be more related with docetaxel than with paclitaxel administration, it is likely that in clinical practice the Growth–Colony Stimulating Factor is often prescribed as a preventive therapy when Docetaxel is administred, giving rise to treatment costs.

scholarly journals TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting

Oncotarget ◽  
2016 ◽  
Vol 7 (22) ◽  
pp. 32731-32753 ◽  
Author(s):  
George Fountzilas ◽  
Eleni Giannoulatou ◽  
Zoi Alexopoulou ◽  
Flora Zagouri ◽  
Eleni Timotheadou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Adjuvant Setting ◽  
Tp53 Mutations ◽  
Poor Outcome

Integrating immunotherapy in the (neo)adjuvant setting of early breast cancer

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jack J. Chan ◽  
Tira J.Y. Tan ◽  
Rebecca A. Dent
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Adjuvant Setting
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