scholarly journals Apparent diffusion coefficient values detected by diffusion-weighted imaging in the prognosis of patients with locally advanced esophageal squamous cell carcinoma receiving chemoradiation

2016 ◽  
Vol Volume 9 ◽  
pp. 5791-5796 ◽  
Author(s):  
Shu Liu ◽  
Fu-Xi Zhen ◽  
Nana Sun ◽  
Jiayan Chen ◽  
Yuandong Cao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Diffusion Coefficient ◽  
Esophageal Squamous Cell Carcinoma ◽  
Apparent Diffusion Coefficient ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diffusion Weighted Imaging ◽  
Locally Advanced ◽  
Apparent Diffusion Coefficient Values ◽  
Apparent Diffusion

scholarly journals Predictive Value of Early Response to Chemoradiotherapy in Advanced Esophageal Squamous Cell Carcinoma by Diffusion-Weighted MR Imaging

2020 ◽  
Vol 19 ◽  
pp. 153303382094322
Author(s):  
Wei Chen ◽  
Ya-ting Wang ◽  
Lili Guo ◽  
Zhaohuan Zhu ◽  
Hai-fei Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Diffusion Coefficient ◽  
Esophageal Squamous Cell Carcinoma ◽  
Apparent Diffusion Coefficient ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Rate Of Change ◽  
Apparent Diffusion Coefficient Value ◽  
Apparent Diffusion

Objective: To explore the value of diffusion-weighted imaging for early response detection of locally advanced esophageal squamous cell carcinoma with concurrent chemoradiotherapy. Methods: Fifty-five (42 males, 13 females) patients with locally advanced esophageal cancer who were undergoing chemoradiotherapy were recruited for this study. Diffusion-weighted imaging was performed in all patients before therapy, at the first weekend, the second weekend, and the end of chemoradiotherapy. The rate of change in apparent diffusion coefficient value and the maximum diameter between pretherapy and posttherapy were calculated. Results: Fifty-five patients with locally advanced esophageal squamous cell carcinoma were classified as responders (40 cases) and nonresponders (15 cases). Before chemoradiotherapy, the responders group had a significantly lower apparent diffusion coefficient values than the nonresponders group ( t = −4.815, P = .000). At the 3 time points after chemoradiotherapy (first weekend, second weekend, and the end of chemoradiotherapy), there was no statistically significant difference in apparent diffusion coefficient values between responders and nonresponders ( P > .05). The responders group had a significantly higher rate of change in apparent diffusion coefficient value than the nonresponders group at each time point ( P < .05). At the first weekend of chemoradiotherapy, the rate of change in the maximum diameter was not significantly different in the 2 groups ( t = 0.928, P = .357). There was a negative correlation between the tumor apparent diffusion coefficient value of pretherapy and the reduction ratio of tumor maximum diameter at the end of chemoradiotherapy ( r = −0.592, P = .000). Conclusions: The change rate of apparent diffusion coefficient value by the end of the first week after beginning chemoradiotherapy may be a sensitive indicator to detect the early response to locally advanced esophageal squamous cell carcinoma.

Whole-tumor histogram analysis of apparent diffusion coefficient for differentiating adenosquamous carcinoma and adenocarcinoma from squamous cell carcinoma in patients with cervical cancer

2021 ◽  
pp. 028418512110359
Author(s):  
Meiling Xiao ◽  
Xiaoliang Ma ◽  
Fenghua Ma ◽  
Yongai Li ◽  
Guofu Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Histogram Analysis ◽  
Characteristic Analysis ◽  
Apparent Diffusion

Background Differentiating adenosquamous carcinoma (ASC) and adenocarcinoma (AC) from squamous cell carcinoma (SCC) precisely is crucial for treatment strategy and prognosis prediction in patients with cervical cancer (CC). Purpose To differentiate ASC and AC from SCC in patients with CC using the apparent diffusion coefficient (ADC) histogram analysis. Material and Methods A total of 118 patients with histologically diagnosed ASC, AC, and SCC were included. The ADC histogram parameters were extracted from ADC maps. Receiver operating characteristic analysis was performed to evaluate the diagnostic performance of each ADC histogram parameter in differentiating the subtypes of CC. The predictors for histologic subtypes were further selected using univariate and multivariate logistic regression analyses. Results The ADCmean, ADCmax, ADCP10, ADCP25, ADCP75, ADCP90, ADCmedian, and ADCmode of the ASC were significantly lower than those of the AC; and ADCkurtosis and ADCskewness of the ASC were lower than those of the SCC. The ADCmean, ADCmax, ADCP10, ADCP25, ADCP75, ADCP90, ADCmedian, and ADCmode of AC were significantly higher than those of the SCC. The ADCP10 and ADCP10 + diameter yielded the AUCs of 0.753 and 0.778 in differentiating ASC from AC. The ADCmedian and ADCmedian + diameter yielded the AUCs of 0.807 and 0.838 in differentiating AC from SCC. The ADCskewness yielded the AUC of 0.713 in differentiating ASC from SCC. Conclusion The ADCP10 and ADCP10 + diameter, ADCmedian, and ADCmedian + diameter performed well in differentiating ASC from AC and AC from SCC, respectively. However, ADCskewness exhibited a limited ability in differentiating ASC from SCC.

Sign in / Sign up

Export Citation Format

Share Document