scholarly journals Association between 17q25.3-rs6465657 polymorphism and prostate cancer susceptibility: a meta-analysis based on 19 studies

2016 ◽  
Vol Volume 9 ◽  
pp. 4491-4503 ◽  
Author(s):  
Huijian Wu ◽  
Xiao Jiang ◽  
Mei Zhang ◽  
Xiao-Yan Bai ◽  
Shujing Li
Keyword(s):  
Prostate Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Prostate Cancer Susceptibility

scholarly journals UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis

ISRN Oncology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Marce-Amara Kpoghomou ◽  
Joella Eldie Soatiana ◽  
Fatch W. Kalembo ◽  
Ghose Bishwajit ◽  
Wei Sheng
Keyword(s):  
Prostate Cancer ◽  
Outcome Measure ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Prostate Cancer Susceptibility ◽  
Increased Risk ◽  
Subgroup Analyses

Objective. Recent studies on the association between uridine diphosphosglucuronosyltransferases (UGTs) 2B17 polymorphism and risk of prostate cancer (PCa) showed inconclusive results. To clarify this possible association, we conducted a meta-analysis of published studies. Methods. We searched the published literature from PubMed, Embase, Google Scholar, and China National Knowledge Infrastructure (CNKI). According to our inclusion criteria, studies that observed the association between UGT2B17 polymorphism and PCa risk were included. The principal outcome measure was the adjusted odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with UGT2B17 polymorphism. Results. A total of 6 studies with 7,029 subjects (3,839 cases and 3,190 controls) were eligible for inclusion in the meta-analysis. Overall, there was a significant association between UGT2B17 polymorphism and increased risk of prostate cancer (, 95% CI 1.14–2.64, ). Similar results were found in the subgroup analyses by ethnicity and types of controls. Conclusion. This meta-analysis demonstrates that UGT2B17 polymorphism is associated with prostate cancer susceptibility, and it contributes to the increased risk of prostate cancer.

scholarly journals Association between Manganese Superoxide Dismutase (MnSOD) Polymorphism and Prostate Cancer Susceptibility: A Meta-Analysis

2016 ◽  
Vol 31 (4) ◽  
pp. 422-430 ◽  
Author(s):  
Xiao Li ◽  
Min Shen ◽  
Hongzhou Cai ◽  
Kang Liu ◽  
Yiyang Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Sufficient Evidence ◽  
Type I ◽  
Prostate Cancer Susceptibility ◽  
Manganese Superoxide ◽  
Val16ala Polymorphism

Background Previous studies have investigated the relationship between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and prostate cancer susceptibility, but the results have remained controversial. This meta-analysis was therefore performed to clarify this association. Methods The databases PubMed, Embase and Web of Science were searched for relevant available studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Trial sequential analysis was used to reduce the risk of type I error and estimate whether the evidence of the results was sufficient. Results Overall, a significant increased risk of prostate cancer was associated with MnSOD Val16Ala polymorphism for the heterozygote model (OR = 1.14; 95% CI, 1.05-1.24), homozygote model (OR = 1.18; 95% CI, 1.02-1.36), dominant model (OR = 1.24; 95% CI, 1.07-1.44) and recessive model (OR = 1.10; 95% CI, 0.96-1.24). In the subgroup analysis by genotyping method, the results were statistically significant for the TaqMan and PCR-RFLP methods. In addition, when stratified by sample size, statistically significant increased risks were found among both large samples and small samples. Furthermore, when stratified by source of control, significant results were detected in both population-based controls and hospital-based controls. By trial sequential analyses, these findings in the current study were shown to be based on sufficient evidence. Conclusions This meta-analysis indicated that the Ala allele of the MnSOD gene polymorphism increases prostate cancer susceptibility.

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