scholarly journals Diagnostic value of BRAFV600E-mutation analysis in fine-needle aspiration of thyroid nodules: a meta-analysis

2016 ◽  
pp. 2495 ◽  
Author(s):  
Lisong Teng ◽  
Xingyun Su ◽  
Xiaoxia Jiang ◽  
Xin Xu ◽  
Weibin Wang ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Brafv600e Mutation ◽  
Fine Needle

scholarly journals Diagnostic value of BRAFV600E mutation analysis in fine needle aspiration for evaluation of thyroid nodules

2018 ◽  
Vol 33 (1) ◽  
pp. 1
Author(s):  
Hae Won Lee ◽  
So Young Ock ◽  
Bu Kyoung Kim ◽  
Su Kyoung Kwon ◽  
Young Sik Choi ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Brafv600e Mutation ◽  
Fine Needle

Diagnostic value of B-RAFV600Ein difficult-to-diagnose thyroid nodules using fine-needle aspiration: Systematic review and meta-analysis

2013 ◽  
Vol 42 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Yongsheng Jia ◽  
Yang Yu ◽  
Xiaolong Li ◽  
Songfeng Wei ◽  
Xiangqian Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Fine Needle

Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules: Systematic Review and Meta-analysis

2017 ◽  
Vol 156 (3) ◽  
pp. 472-479 ◽  
Author(s):  
William Clinkscales ◽  
Adrian Ong ◽  
Shaun Nguyen ◽  
Elizabeth Emily Harruff ◽  
Marion Boyd Gillespie
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Data Sources ◽  
Ras Mutation ◽  
Fine Needle ◽  
Indeterminate Cytology

Objectives To determine the diagnostic value of HRAS, KRAS, and NRAS mutations in fine-needle aspiration biopsies of thyroid nodules that are nondiagnostic on cytology. Data Sources PubMed, Scopus, Embase, CINAHL. Review Methods Two authors independently searched the data sources. To be included, studies reported the RAS mutational status and postoperative histopathologic diagnosis of nodules that exhibited indeterminate cytology after fine-needle aspiration biopsy. Data were extracted to calculate sensitivity, specificity, and positive/negative predictive values of any HRAS, KRAS, or NRAS mutation. A meta-analysis was performed to generate pooled values for each parameter. Results A total of 7 studies with a combined 1025 patients met inclusion criteria. The pooled sensitivity of a RAS mutation for detecting cancer was 0.343 (95% confidence interval [95% CI], 0.198-0.506), while the pooled specificity was 0.935 (95% CI, 0.882-0.973). The weighted averages for positive predictive value and negative predictive value were 78.0% and 64.0%, respectively, with 68.0% accuracy. The positive likelihood ratio was 4.235 (95% CI, 1.506-11.910), and the negative likelihood ratio was 0.775 (95% CI, 0.630-0.953). Conclusion Our data suggest that testing for any RAS mutation is unlikely to change the clinical management of thyroid nodules that have indeterminate cytology. While a RAS mutation may rule in malignancy, the sensitivity of testing is low enough to merit further mutational analysis, repeat fine-needle aspiration, or surgical excision, even in the presence of a negative test.

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