scholarly journals The ocular distribution of 14C-labeled bromfenac ophthalmic solution 0.07% in a rabbit model

2014 ◽  
pp. 1717 ◽  
Author(s):  
George Baklayan ◽  
Mauricio Munoz
Keyword(s):  
Rabbit Model ◽  
Ophthalmic Solution ◽  
Ocular Distribution

scholarly journals Ocular Distribution of Intravenously Administered Lipid Formulations of Amphotericin B in a Rabbit Model

2002 ◽  
Vol 46 (12) ◽  
pp. 3719-3723 ◽  
Author(s):  
David Goldblum ◽  
Kaspar Rohrer ◽  
Beatrice E. Frueh ◽  
Regula Theurillat ◽  
Wolfgang Thormann ◽  
...  
Keyword(s):  
Single Dose ◽  
Amphotericin B ◽  
Rabbit Model ◽  
Lipid Complex ◽  
Dose Administration ◽  
Drug Of Choice ◽  
Drug Concentrations ◽  
Repeated Doses ◽  
Ocular Distribution ◽  
Lipid Formulations

ABSTRACT Little is known about the ocular penetration of amphotericin B (AMB) and its lipid formulations, the current drug of choice in fungal endophthalmitis. The ocular distribution of AMB lipid complex (ABLC), liposomal AMB (L-AMB), and AMB deoxycholate (D-AMB) was studied in a rabbit model. D-AMB (1 mg/kg of body weight/day), ABLC (5 mg/kg/day), or L-AMB (5 mg/kg/day) was given intravenously to rabbits as a single dose or as repeated daily doses on 7 consecutive days after induction of unilateral uveitis by intravitreal injection of endotoxin. AMB concentrations in aqueous humor, vitreous humor, and plasma were determined by high-pressure liquid chromatography 16 h after administration of a single dose or 24 h after the last of seven doses. After single-dose administration, L-AMB achieved at least eightfold-higher AMB concentrations in the aqueous of inflamed eyes than ABLC or D-AMB (1.21 ± 0.58 μg/ml versus 0.14 ± 0.04 and 0.11 ± 0.09 μg/ml, respectively). At that time point no drug was detectable in the vitreous. After 7 days of treatment, the concentration of AMB in the vitreous was higher after treatment with L-AMB (0.47 ± 0.21 μg/ml) than after treatment with ABLC (0.27 ± 0.18 μg/ml) and D-AMB (0.16 ± 0.04 μg/ml). Similarly, AMB concentration in the aqueous was higher after repeated doses of L-AMB (0.73 ± 0.43 μg/ml) than after repeated doses of ABLC (0.03 ± 0.02 μg/ml) or D-AMB (0.13 ± 0.06 μg/ml). No AMB was detected in noninflamed eyes. Following systemic administration, AMB distribution to the eye is inflammation dependent and occurs sequentially, first to the aqueous and then to the vitreous. Compared to D-AMB and ABLC, L-AMB reaches higher drug concentrations in both ocular compartments.

Efficacy of Intravitreal Levofloxacin 0.5% Ophthalmic Solution in Treating Pseudomonas Aeruginosa Endophthalmitis on a Rabbit Model

2013 ◽  
Vol 2 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Yulia Aziza ◽  
Evelina Kodrat ◽  
Yulia Rosa Saharman ◽  
Rianto Setiabudy ◽  
Made Susiyanti ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Rabbit Model ◽  
Ophthalmic Solution

The Fate of Fresh, Layered, Nonsutured and Sutured, Autogenous Cartilage in the Rabbit Model

2000 ◽  
Vol 2 (4) ◽  
pp. 256-259 ◽  
Author(s):  
Joe B. Wiseman ◽  
G. Richard Holt ◽  
Michael A. Keefe ◽  
David E. Holck ◽  
Richard L. Canaan ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Autogenous Cartilage

A new technique to visualize alveolar dynamics in a rabbit model

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
J Bickenbach ◽  
R Rossaint ◽  
R Autschbach ◽  
R Dembinski
Keyword(s):  
Rabbit Model ◽  
New Technique ◽  
A New Technique
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