scholarly journals Efficacy and safety of benzalkonium chloride-free fixed-dose combination of latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension

2014 ◽  
pp. 1241
Author(s):  
Christine Markus ◽  
Purvi Bhagat ◽  
Kalyani VKS ◽  
Chandrima Paul ◽  
SS Pandav ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Benzalkonium Chloride ◽  
Open Angle Glaucoma ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Open Angle ◽  
Efficacy And Safety ◽  
Dose Combination

scholarly journals Treatment of Primary Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost-Timolol Fixed-Dose Combination Versus Preservative-Free Latanoprost-Timolol Fixed-Dose Combination Therapy: Real-World Experience

2021 ◽  
Author(s):  
Ulrich Thelen
Keyword(s):  
Combination Therapy ◽  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Fixed Combination ◽  
Open Angle Glaucoma ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Open Angle ◽  
Dose Combination ◽  
Preservative Free

Abstract Background: To evaluate the effect of an "escalation" of topical glaucoma therapy by switching form prostaglandin monotherapy to two different prostaglandin-timolol fixed combinations.Methods: 30 patients (60 eyes) with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) were initially treated with the prostaglandin analog latanoprost in a preservative-free formulation. 15 patients each were for 6 months - because of IOP levels considered still too high - treated with preservative-free tafluprost/timolol fixed-dose combination or preservative-free latanoprost/timolol fixed-dose combination therapy. Results: Six months after switching from latanopost monotherapy to preservative-free prostaglandin-timolol combinations, patients being treated with the latanoprost-timolol fixed combination had a mean IOP reduction by 4.16 mm Hg and those treated with the tafluprost-timolol fixed combination a mean IOP reduction by 5.38 mm Hg. Regarding safety and tolerability, there were no issues in the tafluprost-timolol group.Conclusions: Switching from prostaglandin monotherapy to a prostaglandin-timolol fixed combination led to a sufficient IOP lowering in our group of patients. Tolerability of, and satisfaction with, the fixed combination therapies was high.

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