scholarly journals Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

2013 ◽  
pp. 1941
Author(s):  
Uchechukwu Osuagwu ◽  
Feryal Zereid
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

scholarly journals Impact of optical coherence tomography scan direction on the reliability of peripapillary retinal nerve fiber layer measurements

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247670
Author(s):  
Abinaya Priya Venkataraman ◽  
Josefine Andersson ◽  
Lina Fivelsdal ◽  
Maria Nilsson ◽  
Alberto Domínguez-Vicent
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
The Right ◽  
Retinal Nerve Fiber

Purpose To evaluate the intradevice repeatability and agreement for peripapillary retinal nerve fiber layer (pRNFL) measurements in healthy eyes with two different scan directions and two different number of B scans. Methods pRNFL was measured with a spectral domain optical coherence tomography on 54 healthy participants. Three-dimensional optic disc scans (6 mm x 6 mm) were performed on the right eye of the participants. Two repeated scans were performed in four different settings: H1: Horizontal scan with 512 A-scans x 96 B-scans; H2: Horizontal scan with 512 A-scans x 128 B-scans; V1: Vertical scan with 512 A-scans x 96 B-scans; V2: Vertical scan with 512 A-scans x 128 B-scans. The pRNFL thickness was evaluated in twelve clock-hour sector in a circle of 3.45 mm diameter centred at the optic disc. Repeatability and agreement were assessed with within subject standard deviation (Sw) and Bland-Altman test respectively. Results The repeatability of pRNFL measurements varied depending on the scan direction and sectors. The repeatability for the horizontal sectors were better with H1 and H2, with sector 9 having the best Sw (< 3 μm). The repeatability for the vertical sectors were better with V1 and V2 with sector 5 and 9 having the best Sw (< 4 μm). The repeatability with vertical scan was more symmetric among the sectors than with horizontal scans. The repeatability metrics of the sectors did not vary much between H1 and H2 (difference < 2 μm) and between V1 and V2 (difference < 3.2 μm). Comparing horizontal and vertical scans, the vertical sectors had larger limits of agreement of about 45 μm. Conclusion The reliability of the pRNFL thickness measurements is dependent on the direction of the scan and independent on the numbers of B-scans. Vertical scans for pRNFL gives more homogeneous repeatability across the different sectors.

Retinal Nerve Fiber and Optic Disc Morphology Using Spectral-Domain Optical Coherence Tomography in Scleroderma Patients

2016 ◽  
Vol 27 (3) ◽  
pp. 281-284 ◽  
Author(s):  
Sevinc Sahin-Atik ◽  
Feray Koc ◽  
Sirin Akin-Sari ◽  
Mustafa Ozmen
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Normal Tension Glaucoma ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sd Oct ◽  
Retinal Nerve Fiber

Purpose To evaluate the optic nerve head parameters and peripapillary retinal nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in a systemic sclerosis (SSc) cohort and age-matched controls to determine whether SSc patients have an increased risk of normal-tension glaucoma (NTG). Methods We examined 30 patients (3 male, 27 female) with SSc and 28 age- and sex-matched controls. Retinal nerve fiber and optic disc morphology were evaluated using Cirrus SD-OCT. Results Optic disc morphology measurements including disc area, rim area, average and vertical cup/disc (C/D) ratio, and cup volume were not significantly different between the study groups. The average and 4-quadrant retinal nerve fiber layer (RNFL) measurements of the C/D >0.3 subgroups were not significantly different in the patients and controls. These values were also similar for the C/D >0.5 subgroups except that the average inferior quadrant RNFL thickness of the right eyes in the patient subgroup was significantly thinner than in the control subgroup (p<0.05). Conclusions Our SSc cohort had relatively shorter disease duration but increased prevalence of early glaucomatous damage signs. Our findings indicate that SSc is a risk factor for developing normal-tension glaucoma. Further studies combined with visual field evaluation are necessary to identify the long-term glaucomatous effects of SSc.

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