scholarly journals In situ carcinoma of the conjunctiva: surgical excision associated with cryotherapy

2013 ◽  
pp. 1889
Author(s):  
Julio Urrets-Zavalía ◽  
María Elena Forniés Paz ◽  
Rodolfo Monti ◽  
Evangelina Espósito ◽  
Juan Pablo Maccio ◽  
...  
Keyword(s):  
Surgical Excision ◽  
In Situ Carcinoma

Radiation-Associated Primary Osteosarcoma of the Breast

Pathobiology ◽  
2020 ◽  
Vol 87 (5) ◽  
pp. 322-326
Author(s):  
Helen Bartlett ◽  
Maiar Elghobashy ◽  
Nayneeta Deshmukh ◽  
Rashmi Rao ◽  
Abeer M. Shaaban
Keyword(s):  
Ductal Carcinoma ◽  
Surgical Excision ◽  
Metaplastic Carcinoma ◽  
Post Irradiation ◽  
In Situ Carcinoma ◽  
Complete Surgical Excision ◽  
Spindle Cell Lesion ◽  
Phyllodes Tumour

<b><i>Introduction:</i></b> Non-epithelial primary mammary osteosarcomas are extremely rare. The differentials include metaplastic carcinoma and malignant phyllodes tumour. This is the first published case of primary breast osteosarcoma arising after local radiotherapy. <b><i>Case Presentation:</i></b> A 73-year-old female presented with a right-sided breast lump. The same breast had been irradiated 11 years previously for invasive ductal carcinoma. Diagnostic excision revealed a highly cellular, malignant spindle-cell lesion merged with an osteoid matrix and foci of calcification and bone formation. Immunohistochemistry and molecular studies showed no lines of differentiation. Due to the lack of epithelial/glandular differentiation, in situ carcinoma or leaf-like pattern, the diagnosis of post-irradiation osteosarcoma was made. She underwent mastectomy and is disease-free at 8 months of follow-up. <b><i>Conclusion:</i></b> Post-irradiation osteosarcoma should be considered in the differential diagnosis of breast lesions showing malignant osteoid. Extensive sampling and careful search for epithelial differentiation is required to guide management. Complete surgical excision is recommended.

scholarly journals Papillary Neoplasm of Breast-Changing Trends in Diagnosis and Management

2021 ◽  
Author(s):  
Amrit Pal Singh Rana ◽  
Manjit Kaur Rana
Keyword(s):  
Invasive Carcinoma ◽  
Treatment Guidelines ◽  
Nipple Discharge ◽  
Diagnostic Technique ◽  
Surgical Excision ◽  
Bloody Nipple Discharge ◽  
Non Invasive ◽  
In Situ Carcinoma ◽  
Papillary Neoplasm

Papillary neoplasm of breast comprises of seven separate heterogeneous entities ranging from benign, atypical and malignancy including non-invasive and invasive carcinoma. Papillary carcinoma (PC) is seen more commonly in older postmenopausal women with favorable prognosis. PC breast typically presents with bloody nipple discharge and an abnormal mass with radiologic features of intraductal mass. Encapsulated PC and solid PC is to be treated as in situ carcinoma, but distinction of invasive PC from non invasive carcinoma is critical both at microscopic and molecular level. So, surgical excision should be the choice of definitive diagnostic technique in papillary neoplasm instead of core needle biopsy. Furthermore, treatment guidelines for invasive PC also have been framed, but incidence of recurrence and death attributable to various subtypes of carcinoma remained same. So, this is important topic to be addressed to understand the need for further management and outcome of the disease.

Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

2021 ◽  
pp. 106689692110029
Author(s):  
Kerschen Anja ◽  
Dano Hélène ◽  
Van Eeckhout Pascal ◽  
Marot Liliane ◽  
Van Bockstal Mieke
Keyword(s):  
Present Report ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Cytokeratin 7 ◽  
In Situ Carcinoma ◽  
Epidermal Growth ◽  
Mammary Paget’S Disease

Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.

Low diffusion level within a fibroadenoma as the sole sign of ductal carcinoma in situ: A case report

2021 ◽  
pp. 1-4
Author(s):  
Corrado Tagliati ◽  
Giuseppe Lanni ◽  
Federico Cerimele ◽  
Antonietta Di Martino ◽  
Valentina Calamita ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Surgical Excision ◽  
Small Region ◽  
Apparent Diffusion Coefficient Value ◽  
Apparent Diffusion

We present a case of ductal carcinoma in situ within a fibroadenoma. Breast cancer arising within fibroadenoma incidence ranges from 0.125% to 0.02%, and ductal carcinoma in situ is not the most frequent malignancy that can be found within a fibroadenoma. Dynamic contrast-enhanced magnetic resonance imaging showed an oval mass with circumscribed margins and dark internal septations, suspicious for fibroadenoma. According to European Society of Breast Radiology diffusion-weighted imaging consensus, mean apparent diffusion coefficient value obtained by drawing a small region of interest on the lesion apparent diffusion coefficient map showed a low diffusion level. Therefore, ductal carcinoma in situ within a fibroadenoma was diagnosed at final pathology after surgical excision.

scholarly journals In situ carcinoma developed over oral lichen planus: a case report with analysis of BUB3, p16, p53, Ki67 and SOX4 expression

2015 ◽  
Vol 23 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Eduardo Augusto ROSA ◽  
Erica Negrini LIA ◽  
Sergio Bruzadelli MACEDO ◽  
Rivadavio Fernandes Batista de AMORIM
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
In Situ Carcinoma ◽  
Oral Lichen

Smear diagnosis of in situ carcinoma of the cervix

1948 ◽  
Vol 56 (2) ◽  
pp. 335-339 ◽  
Author(s):  
Frank W. Foote ◽  
Katherine Li
Keyword(s):  
In Situ Carcinoma

Genomic characterization of Felis catus papillomavirus-3: A novel papillomavirus detected in a feline Bowenoid in situ carcinoma

2013 ◽  
Vol 165 (3-4) ◽  
pp. 319-325 ◽  
Author(s):  
John S. Munday ◽  
Magda Dunowska ◽  
Simon F. Hills ◽  
Rebecca E. Laurie
Keyword(s):  
Felis Catus ◽  
In Situ Carcinoma ◽  
Genomic Characterization
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