scholarly journals Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket

2021 ◽  
Vol Volume 15 ◽  
pp. 4621-4627
Author(s):  
Hala K Mattout ◽  
Sameh M Fouda ◽  
Haitham Y Al-Nashar‎
Keyword(s):  
Mitomycin C ◽  
Reconstructive Surgery ◽  
Eye Drops ◽  
Contracted Socket

scholarly journals Avoiding BAK in postoperative eye drops reduces the need for subconjunctival 5-FU injections post-trabeculectomy

2020 ◽  
Vol 17 (1) ◽  
pp. 128-131
Author(s):  
Keith Ong ◽  
Leonard Ong
Keyword(s):  
Intraocular Pressure ◽  
Mitomycin C ◽  
T Test ◽  
Topical Steroids ◽  
Eye Drops ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Group A ◽  
Group B ◽  
Causes Of Failure

Purpose: Subconjunctival fibrosis is one of the main causes of failure of glaucoma filtration surgery. It can result in absence of a filtration bleb, a small scarred bleb, or a cystic bleb. 5-Fluorouracil (5-FU), mitomycin C (MMC), and topical steroids have been used to suppress subconjunctival fibrosis. Method: A study was done analyzing the number of postoperative subconjunctival 5-FU injections for trabeculectomy on pseudophakic eyes prior to and following the change to a BAK-free regimen. The cohort consisted of 16 consecutive cases undergoing primary trabeculectomy without intraoperative MMC or 5-FU. The trabeculectomy surgery included a groove sclerectomy procedure. Group A were 8 eyes of patients who had the author’s standard Chlorsig, Maxidex, and Prednefrin Forte eye drops tds. Group B were 8 eyes who had Chlorsig-dexamethasone and Optive-dexamethasone tds eye drops postoperatively. Results: Group B (BAK-free) patients required fewer postoperative 5-FU subconjunctival injections (average: 2.9, range: 1-5 injections) compared to Group A (BAK) patients (average: 7.3, range: 4-18 injections). This difference was statistically significant (P = 0.02, unpaired t-test). All patients had functioning blebs and did not require glaucoma medications to maintain target intraocular pressure. The Group B (BAK-free) patients had more diffuse blebs than the Group A (BAK) patients. Conclusion: The results demonstrated that when BAK was eliminated from postoperative eye drops in trabeculectomy, the number of postoperative 5-FU injections was reduced.

scholarly journals Delayed Onset Scleromalacia and Conjunctival Bleb Formation Following Intraoperative Mitomycin C Application during Conjunctival Melanoma Excision

Vision ◽  
2020 ◽  
Vol 4 (2) ◽  
pp. 24
Author(s):  
Syed Naqib Ahmed ◽  
Syed Mohammed Shahid ◽  
Mayank A. Nanavaty
Keyword(s):  
Mitomycin C ◽  
Eye Drops ◽  
Conjunctival Melanoma ◽  
Freeze Thaw ◽  
Delayed Onset ◽  
Oral Steroids ◽  
Bleb Formation ◽  
Eye Examination ◽  
One Year ◽  
Conjunctival Bleb

Purpose: To present a case of delayed onset scleromalacia and conjunctival bleb formation one year after conjunctival melanoma excision with intraoperative use of mitomycin-C (MMC) and double-freeze-thaw technique. Methods: Case report. Results: A 69-year-old woman had a conjunctival melanoma excised by the ‘no touch technique’ with intraoperative application of 0.02% MMC for 3 min on bare sclera, freeze-thaw cryotherapy and amniotic membrane transplant performed elsewhere. Three months later, she presented to us with a red, sore and painful right eye. Examination revealed severe scleritis. She was treated with lubricants and oral steroids for 6 weeks. She settled well with no recurrence of melanoma. At one year, she developed scleromalacia and conjunctival blebs in the inferonasal quadrant of right eye. She remains under closer observation as she is at high risk of perforation. Conclusion: Caution should be exercised with intraoperative use of MMC on bare sclera during excision and cryotherapy of conjunctival melanoma. As published in the literature, when using MMC, it is recommended to use the lowest dose topically in the form of eye drops in the postoperative period for the shortest time to avoid any sight-threatening complications.

Mucous Membrane Grafting Augmented with Topical Mitomycin C Application in Contracted Socket Repair Surgeries

2016 ◽  
Vol 32 (10) ◽  
pp. 691-694 ◽  
Author(s):  
Sameh S. Mandour ◽  
Hesham M. Elmazar ◽  
Hatem M. Marey ◽  
Ahmed K. Abdel Rahman ◽  
Rokia A. Sakr
Keyword(s):  
Mitomycin C ◽  
Mucous Membrane ◽  
Contracted Socket

scholarly journals Effectiveness of trabeculectomy with mitomycin C for glaucomatous eyes with low intraocular pressure on treatment eye drops

2019 ◽  
Vol 98 (1) ◽  
Author(s):  
Yuki Yuasa ◽  
Yosuke Sugimoto ◽  
Kazuyuki Hirooka ◽  
Shinji Ohkubo ◽  
Tomomi Higashide ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Mitomycin C ◽  
Eye Drops

scholarly journals Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C

Eye ◽  
2006 ◽  
Vol 22 (4) ◽  
pp. 507-514 ◽  
Author(s):  
H Sagara ◽  
T Iida ◽  
K Suzuki ◽  
T Fujiwara ◽  
H Koizumi ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Late Onset ◽  
Sodium Hyaluronate ◽  
Eye Drops

scholarly journals Can postoperative dexamethasone nanoparticle eye drops replace mitomycin C in trabeculectomy?

2020 ◽  
Vol 98 (6) ◽  
pp. 607-612
Author(s):  
Gauti Jóhannesson ◽  
María Soffía Gottfredsdóttir ◽  
Guðrún Marta Ásgrimsdóttir ◽  
Thorsteinn Loftsson ◽  
Einar Stefánsson
Keyword(s):  
Mitomycin C ◽  
Eye Drops

scholarly journals Effects of Regorafenib, a Multi-Kinase Inhibitor, on Conjunctival Scarring in a Canine Filtration Surgery Model in Comparison with Mitomycin-C

2019 ◽  
Vol 21 (1) ◽  
pp. 63
Author(s):  
Emika Nemoto ◽  
Shota Kojima ◽  
Tetsuya Sugiyama ◽  
Denan Jin ◽  
Shinji Takai ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Kinase Inhibitor ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Eye Drops ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Significant Difference ◽  
Bleb Formation ◽  
Collagen Density

Regorafenib eye drops were developed for treating age-related macular degeneration. This study aimed to investigate the effects of this multi-kinase inhibitor on intraocular pressure (IOP), bleb formation, and conjunctival changes in a canine filtration surgery model. Glaucoma filtration surgery models were created in 24 eyes of 24 beagles. In experiment 1 (Ex 1), regorafenib eye drops (regorafenib group: n = 6) or a vehicle (control group, n = 6) were instilled twice daily for 4 weeks postoperatively. In experiment 2 (Ex 2), regorafenib eye drops were instilled as in Ex 1 (regorafenib group: n = 6) for 12 weeks while conventional intraoperative mitomycin-C (MMC) was utilized (MMC group: n = 6), In Ex 1, only the regorafenib group showed significant IOP reduction with a significantly higher bleb score. Subconjunctival area, collagen density, vessels, and cells showing proliferation and differentiation were lower in subconjunctival tissue in the regorafenib group. In Ex 2, no significant difference was found in IOP reduction and bleb formation between the regorafenib and MMC groups; bleb walls were significantly thicker and collagen density and vessels were higher in the regorafenib group; and no differences were observed in the above-mentioned cells. Thus, regorafenib might be a better alternative to MMC for creating thicker and less ischemic blebs in glaucoma filtration surgery.

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