scholarly journals A comparative study of the safety and efficacy effect of 5-fluorouracil or mitomycin C mounted biological delivery membranes in a rabbit model of glaucoma filtration surgery

2013 ◽  
pp. 655 ◽  
Author(s):  
Zhihong Wu ◽  
Ningli Wang ◽  
Shuning Li ◽  
Wanshun Liu ◽  
Wen Liu
Keyword(s):  
Comparative Study ◽  
Mitomycin C ◽  
Rabbit Model ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Safety And Efficacy

scholarly journals Avoiding BAK in postoperative eye drops reduces the need for subconjunctival 5-FU injections post-trabeculectomy

2020 ◽  
Vol 17 (1) ◽  
pp. 128-131
Author(s):  
Keith Ong ◽  
Leonard Ong
Keyword(s):  
Intraocular Pressure ◽  
Mitomycin C ◽  
T Test ◽  
Topical Steroids ◽  
Eye Drops ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Group A ◽  
Group B ◽  
Causes Of Failure

Purpose: Subconjunctival fibrosis is one of the main causes of failure of glaucoma filtration surgery. It can result in absence of a filtration bleb, a small scarred bleb, or a cystic bleb. 5-Fluorouracil (5-FU), mitomycin C (MMC), and topical steroids have been used to suppress subconjunctival fibrosis. Method: A study was done analyzing the number of postoperative subconjunctival 5-FU injections for trabeculectomy on pseudophakic eyes prior to and following the change to a BAK-free regimen. The cohort consisted of 16 consecutive cases undergoing primary trabeculectomy without intraoperative MMC or 5-FU. The trabeculectomy surgery included a groove sclerectomy procedure. Group A were 8 eyes of patients who had the author’s standard Chlorsig, Maxidex, and Prednefrin Forte eye drops tds. Group B were 8 eyes who had Chlorsig-dexamethasone and Optive-dexamethasone tds eye drops postoperatively. Results: Group B (BAK-free) patients required fewer postoperative 5-FU subconjunctival injections (average: 2.9, range: 1-5 injections) compared to Group A (BAK) patients (average: 7.3, range: 4-18 injections). This difference was statistically significant (P = 0.02, unpaired t-test). All patients had functioning blebs and did not require glaucoma medications to maintain target intraocular pressure. The Group B (BAK-free) patients had more diffuse blebs than the Group A (BAK) patients. Conclusion: The results demonstrated that when BAK was eliminated from postoperative eye drops in trabeculectomy, the number of postoperative 5-FU injections was reduced.

scholarly journals History, presence, and future of mitomycin C in glaucoma filtration surgery

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jarno E.J. Wolters ◽  
Ralph J.S. van Mechelen ◽  
Rana Al Majidi ◽  
Leonard Pinchuk ◽  
Carroll A.B. Webers ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery

scholarly journals Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138054 ◽  
Author(s):  
Gina M. Martorana ◽  
Jamie L. Schaefer ◽  
Monica A. Levine ◽  
Zachary L. Lukowski ◽  
Jeff Min ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Sequential Therapy ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery

Aqueous and Vitreous Concentration of Mitomycin C by Topical Administration after Glaucoma Filtration Surgery in Rabbits

Ophthalmology ◽  
1993 ◽  
Vol 100 (10) ◽  
pp. 1574-1579 ◽  
Author(s):  
David Sarraf ◽  
R. Deborah Eezzuduemhoi ◽  
Qi Cheng ◽  
M. Roy Wilson ◽  
David A. Lee
Keyword(s):  
Mitomycin C ◽  
Topical Administration ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery

scholarly journals The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 896
Author(s):  
Vanessa Andrés-Guerrero ◽  
Irene Camacho-Bosca ◽  
Liseth Salazar-Quiñones ◽  
Nestor Ventura-Abreu ◽  
Mercedes Molero-Senosiain ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Rabbit Model ◽  
Sodium Hyaluronate ◽  
Collagen Matrix ◽  
New Combination ◽  
Wound Healing Process ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Fibroblast Migration

Currently available anti-scarring treatments for glaucoma filtration surgery (GFS) have potentially blinding complications, so there is a need for alternative and safer agents. The effects of the intrableb administration of a new combination of the anti-VEGF bevacizumab, sodium hyaluronate and a collagen matrix implant were investigated in a rabbit model of GFS, with the purpose of modulating inflammation, angiogenesis, fibroblast migration and fibrogenesis in the wound healing process. A comparative-effectiveness study was performed with twenty-four rabbits, randomly assigned to the following treatments: (a) biodegradable collagen matrix implant (Olo), (b) bevacizumab-loaded collagen matrix implant (Olo-BVZ), (c) bevacizumab-loaded collagen matrix implant combined with sodium hyaluronate (Olo-BVZ-H5) and (d) sham-operated animals (control). Rabbits underwent a conventional trabeculectomy and were studied over 30 days in terms of intraocular pressure and bleb characterization (height, area and vascularity in central, peripheral and non-bleb zones). Histologic differences among groups were further evaluated at day 30 (inflammation, total cellularity and degree of fibrosis in the area of surgery). Local delivery of bevacizumab (Olo-BVZ and Olo-BVZ-H5) increased the survival of the filtering bleb by 21% and 31%, respectively, and generated a significant decrease in inflammation and cell infiltration histologically 30 days after surgery, without exhibiting any local toxic effects. Olo-BVZ-H5 showed less lymphocyte infiltration and inflammation than the rest of the treatments. Intraoperative intrableb implantation of bevacizumab, sodium hyaluronate and a collagen matrix may provide an improved trabeculectomy outcome in this model of intense wound healing. This study showed an effective procedure with few surgical complications and a novel combination of active compounds that offer new possibilities to improve the efficacy of filtration surgery.

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