scholarly journals Corneal Epithelial Stem Cell Supernatant in the Treatment of Severe Dry Eye Disease: A Pilot Study

2021 ◽  
Vol Volume 15 ◽  
pp. 3097-3107
Author(s):  
Sloan W Rush ◽  
Jennifer Chain ◽  
Hiranmoy Das
Keyword(s):  
Stem Cell ◽  
Pilot Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Epithelial Stem Cell ◽  
Cell Supernatant

scholarly journals Epithelial stem cell homeostasis in Meibomian gland development, dysfunction, and dry eye disease

JCI Insight ◽  
2021 ◽  
Author(s):  
Edem Tchegnon ◽  
Chung-Ping Liao ◽  
Elnaz Ghotbi ◽  
Tracey Shipman ◽  
Yong Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dry Eye ◽  
Meibomian Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Cell Homeostasis ◽  
Epithelial Stem Cell ◽  
Gland Development

scholarly journals Therapeutic Potential of Limbal Mesenchymal Stem Cell Secretome for Repair Ocular Surface in Experimental of Dry Eye Disease

2021 ◽  
Vol 83 (1) ◽  
Author(s):  
Ni Made Inten Lestari ◽  
Evelyn Komaratih ◽  
Fedik A. Rantam ◽  
Yuyun Rindiastuti ◽  
Cita Rosita Sigit Prakoeswa
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Dry Eye ◽  
Ocular Surface ◽  
Therapeutic Potential ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals Corneal Epithelial Immune Dendritic Cell Alterations in Subtypes of Dry Eye Disease: A Pilot In Vivo Confocal Microscopic Study

2015 ◽  
Vol 56 (12) ◽  
pp. 7179 ◽  
Author(s):  
Ahmad Kheirkhah ◽  
Raheleh Rahimi Darabad ◽  
Andrea Cruzat ◽  
Amir Reza Hajrasouliha ◽  
Deborah Witkin ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Microscopic Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Cell Alterations ◽  
Confocal Microscopic Study

scholarly journals Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents

2021 ◽  
Vol Volume 15 ◽  
pp. 1425-1431
Author(s):  
Weam Mohamed Ebeid ◽  
Mahmoud Adel Kenny ◽  
Tamer AbdelFattah Badran
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease

2021 ◽  
Vol 19 ◽  
pp. 43-52
Author(s):  
Michael Møller-Hansen ◽  
Ann-Cathrine Larsen ◽  
Peter Bjerre Toft ◽  
Charlotte Duch Lynggaard ◽  
Camilla Schwartz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Dry Eye ◽  
Stem Cell Therapy ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Mesenchymal Stem Cell Therapy

scholarly journals Achyranthis radix Extract Improves Urban Particulate Matter-Induced Dry Eye Disease

2019 ◽  
Vol 16 (18) ◽  
pp. 3229 ◽  
Author(s):  
Tae Gu Lee ◽  
Soo-Wang Hyun ◽  
Kyuhyung Jo ◽  
Bongkyun Park ◽  
Ik Soo Lee ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Water Extract ◽  
Dry Eye Disease ◽  
Hot Water ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Urban Particulate Matter ◽  
Eye Health ◽  
Induced Apoptosis

Dry eye disease (DED) is a multifactorial inflammatory disease that severely impairs patients’ quality of life. Particulate matter comprises a harmful mixture of particles less than 10 μm in size, which on contact with the eye, causes inflammation in the cornea/conjunctival epithelium, threatening eye health and triggering the onset of DED. Achyranthis radix is an ingredient of traditional medicine generally used for treating osteoporosis, trauma, and thrombosis in Asian countries. However, the effect of Achyranthis radix on eye health has not been elucidated. In this study, we evaluate the protective effect of Achyranthis radix hot water extract (ARE) in a rat model of urban particulate matter (UPM)-induced DED. UPM with or without ARE were topically administered on both eyes thrice daily for 10 days. ARE induced tear secretion and improved corneal irregularity. Additionally, ARE treatment protected the corneal epithelial cells from UPM-induced apoptosis. It also restored rMuc4 expression in the cornea and increased goblet cell density in the conjunctiva. These results are suggestive of the potential of ARE as a topical therapeutic agent for treating DED.

New model to better diagnose dry eye disease integrating OCT corneal epithelial mapping

2021 ◽  
pp. bjophthalmol-2021-318826
Author(s):  
Norah A Edorh ◽  
Adil El Maftouhi ◽  
Zoubir Djerada ◽  
Carl Arndt ◽  
Alexandre Denoyer
Keyword(s):  
Dry Eye ◽  
Roc Curves ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Control Group ◽  
Scoring Method ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Final Multivariable Model ◽  
The Difference

PurposeTo optimise the objective diagnosis of dry eye disease (DED), the capabilities of wide corneal epithelial mapping using optical coherence tomography (OCT) were studied and subsequently integrated into a new scoring method.MethodsFifty-nine patients (118 eyes) with DED and 55 control subjects (110 eyes) were included. All patients underwent a complete ocular surface evaluation. Corneal epithelial thickness was collected using OCT for seven zones. DED and the control group were compared using a t-test, and univariate receiver operating characteristic (ROC) curves were calculated to define the diagnostic ability of OCT epithelial mapping. Multivariate analyses were performed using artificial intelligence (random forest) and logistic regression approaches to define the best way to integrate OCT mapping in the diagnosis of DED. Then, a final multivariable model for diagnosing DED was validated through a bootstrapping method.ResultsThe DED group had significant epithelial thinning compared with the controls, regardless of location. Superior intermediate epithelial thickness was the best marker for diagnosing DED using OCT (binormal estimated area under ROC: 0.87; best cut-off value: 50 µm thickness). The difference between the inferior and superior peripheral zones was the best marker for grading the severity of DED (analysis of variance, p=0.009). A multivariate approach identified other significant covariables which were integrated into a multivariate model to improve the sensitivity (86.4%) and specificity (91.7%) of this innovative diagnostic method.ConclusionIncluding OCT corneal epithelial mapping in a new diagnostic tool for DED could allow optimisation of the screening and staging of the disease in current practice as well as for clinical research purposes.

scholarly journals Corneal epithelial thickness profile in dry-eye disease

Eye ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 915-922 ◽  
Author(s):  
Mohamed Abou Shousha ◽  
Jianhua Wang ◽  
George Kontadakis ◽  
William Feuer ◽  
Ana P. Canto ◽  
...  
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Thickness Profile ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

scholarly journals Randomized, Controlled, Double-Masked, Multicenter, Pilot Study Evaluating Safety and Efficacy of Intranasal Neurostimulation for Dry Eye Disease

2019 ◽  
Vol 60 (1) ◽  
pp. 147 ◽  
Author(s):  
Geoffrey S. Cohn ◽  
Dean Corbett ◽  
Abi Tenen ◽  
Minas Coroneo ◽  
James McAlister ◽  
...  
Keyword(s):  
Pilot Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Safety And Efficacy ◽  
Randomized Controlled
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