scholarly journals Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging

2021 ◽  
Vol Volume 15 ◽  
pp. 2953-2962
Author(s):  
Unnikrishnan Nair ◽  
Jay U Sheth ◽  
Asmita Indurkar ◽  
Manoj Soman
Keyword(s):  
Structure Function ◽  
Macular Hole ◽  
En Face ◽  
Function Correlation ◽  
Intraretinal Cysts ◽  
En Face Imaging

En-face Imaging of Atypical Epiretinal Tissue in Lamellar Macular Hole

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jun Soo Eun ◽  
Young Joo Choi ◽  
Se Woong Kang ◽  
Kyung Jun Choi ◽  
Sang Jin Kim ◽  
...  
Keyword(s):  
Macular Hole ◽  
Lamellar Macular Hole ◽  
En Face ◽  
En Face Imaging

scholarly journals Intraretinal cysts in Macular Hole: A structure-function correlation based on en face imaging

2021 ◽  
Author(s):  
Unnikrishnan Nair ◽  
Jay Sheth ◽  
Asmita Indurkar ◽  
Manoj Soman
Keyword(s):  
Macular Hole ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Basal Diameter ◽  
En Face ◽  
Group 2 ◽  
Intraretinal Cysts ◽  
Group 1

Abstract This study determines and characterizes the role of retinal micromorphic changes on en-face optical-coherence tomography(OCT) in macular-hole(MH) surgery. Pre-and post-operative parameters including MH basal-diameter(BD) and minimal inlet-area(MIA), inner-plexiform layer(IPL) and outer-plexiform layer(OPL) cyst-area, IPL and OPL cyst-percentage, and amount of defect in ellipsoid-zone(EZ) and external-limiting membrane(ELM) were compared amongst 28 eyes undergoing successful MH surgery. Their relationship with visual-acuity(VA) outcomes(Group-1: ≥ 20/60;14 eyes; Group-2: < 20/60;14 eyes) was also evaluated. We noted a significant positive correlation between the OPL and IPL cyst-area(r = 0.768;p < 0.001), which in turn were positively correlated with the MH-BD in all eyes. The cyst area was significantly more in IPL as compared to OPL in all eyes (p = 0.049) and in group-2(p = 0.03), but not in group-1(p = 0.62). As compared to group-2, eyes in group-1 had significantly better pre-and post-operative-VA, and significantly smaller BD, MIA, IPL and OPL cyst-area, and ELM(post-operative) and EZ(Pre-and post-operative) defect, respectively. To conclude, an increase in the MH-BD is associated with a simultaneous congruous enlargement of the IPL and OPL cyst-area. The origin of intraretinal cysts could be secondary to breakdown in the physiological retinal-pigment epithelium(RPE) pump due to the anatomical separation of the neurosensory retina from the underlying RPE, i.e., "RPE contact-loss" theory.

Quasi-simultaneous OCT en-face imaging with two different depth resolutions

2003 ◽  
Vol 36 (14) ◽  
pp. 1696-1702 ◽  
Author(s):  
Adrian Gh Podoleanu ◽  
Radu G Cucu ◽  
Richard B Rosen ◽  
George M Dobre ◽  
John A Rogers ◽  
...  
Keyword(s):  
En Face ◽  
En Face Imaging

scholarly journals The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ching-Wen Huang ◽  
Jung-Je Yang ◽  
Chang-Hao Yang ◽  
Chung-May Yang ◽  
Fung-Rong Hu ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Structure Function ◽  
Subgroup Analysis ◽  
Primary Analysis ◽  
Cross Sectional ◽  
Zone Length ◽  
Full Field ◽  
Multiple Parameters ◽  
Typical Type ◽  
Function Correlation

AbstractTo investigate the structure–function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual acuity (BCVA) and multiple parameters. A total of 188 eyes were included. Amplitudes of responses of rod, rod-cone, cone, and 30 Hz flicker of typical type were lower than those of pericentral and other types. In the subgroup analysis, 41 and 21 eyes of the typical and pericentral types were studied, respectively. The correlation between the estimated preserved photoreceptor area and all ffERG amplitude parameters were significant in the typical type, but not in pericentral type. Old age, decreased intact ellipsoid zone length, typical type, and thin central retinal thickness were negatively correlated with BCVA. Typical type RP developed more extensive degeneration and poorer BCVA compared to others. Strong structure–function correlation was found in typical type while not in pericentral type. OCT may be a useful tool for monitoring RP status in typical type, providing useful parameters for the prediction of BCVA.

Structure−Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Nonviral Gene Delivery

2006 ◽  
Vol 49 (22) ◽  
pp. 6522-6531 ◽  
Author(s):  
Jianjun Cheng ◽  
Ryan Zeidan ◽  
Swaroop Mishra ◽  
Aijie Liu ◽  
Suzie H. Pun ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Function ◽  
Transgene Expression ◽  
Nonviral Gene Delivery ◽  
Function Correlation

Macromolecular Prodrugs of Ribavirin: Structure–Function Correlation as Inhibitors of Influenza Infectivity

2016 ◽  
Vol 14 (1) ◽  
pp. 234-241 ◽  
Author(s):  
Camilla Frich Riber ◽  
Tracey M. Hinton ◽  
Paulina Gajda ◽  
Kaja Zuwala ◽  
Martin Tolstrup ◽  
...  
Keyword(s):  
Structure Function ◽  
Function Correlation ◽  
Macromolecular Prodrugs

Structure–function correlation of human programmed cell death 5 protein

2009 ◽  
Vol 486 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Hongwei Yao ◽  
Lanjun Xu ◽  
Yingang Feng ◽  
Dongsheng Liu ◽  
Yingyu Chen ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Structure Function ◽  
Function Correlation ◽  
Programmed Cell Death 5

scholarly journals Optical Coherence Tomography Findings in Idiopathic Macular Holes

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Lynn L. Huang ◽  
David H. Levinson ◽  
Jonathan P. Levine ◽  
Umar Mian ◽  
Irena Tsui
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Hole ◽  
Clinical Assessment ◽  
Chart Review ◽  
Subretinal Fluid ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Macular Holes ◽  
Idiopathic Macular Holes ◽  
Intraretinal Cysts

Purpose. To describe the characteristics of idiopathic macular holes (MH) on optical coherence tomography (OCT) and correlate OCT with clinical assessment.Design. Cross-sectional chart review and OCT assessment.Participants. Sixty-seven eyes with a clinically diagnosed idiopathic MH with available OCT data.Methods. A retrospective chart review and OCT assessment.Results. Based on OCT grading, 40 eyes had a full-thickness macular hole (FTMH) and 21 eyes had a lamellar macular hole (LMH). Clinical exam and OCT assessment agreed in 53 (87%) eyes when assessing the extent of MH. Six eyes (14.6%) in the FTMH group, and 3 eyes in the LMH group (14.3%) had persistent vitreomacular traction. Thirty-seven eyes (92.5%) in the FTMH group and 11 eyes (52.4%) in the LMH group had associated intraretinal cysts. Two eyes (5.0%) in the FTMH group and zero eyes in the LMH group had subretinal fluid. Intraretinal cysts were found to be more frequently associated with FTMH than with LMH (P<0.001).Conclusion. This paper described OCT findings in a group of patients with clinically diagnosed MH. A high level of correlation between clinical assessment and OCT findings of LMH and FTMH was observed, and intraretinal cysts were often present in FTMH.

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