scholarly journals Novel Needle for Intravitreal Drug Delivery: Comparative Study of Needle Tip Aspirates, Injection Stream and Penetration Forces

2021 ◽  
Vol Volume 15 ◽  
pp. 723-734
Author(s):  
Lyubomyr M Lytvynchuk ◽  
Goran Petrovski ◽  
Adien Dam ◽  
Joep Hiemstra ◽  
Tobias Wimmer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Comparative Study ◽  
Intravitreal Drug Delivery

scholarly journals A Gentle Sedimentation Process for Size-Selecting Porous Silicon Microparticles to Be Used for Drug Delivery Via Fine Gauge Needle Administration

Silicon ◽  
2020 ◽  
Author(s):  
Elida Nekovic ◽  
Catherine J. Storey ◽  
Andre Kaplan ◽  
Wolfgang Theis ◽  
Leigh T. Canham
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Porous Silicon ◽  
Particle Sizes ◽  
Size Distributions ◽  
Particle Agglomeration ◽  
Gas Generation ◽  
Intravitreal Drug Delivery ◽  
Median Diameter ◽  
Experimental Values

AbstractBiodegradable porous silicon (pSi) particles are under development for drug delivery applications. The optimum particle size very much depends on medical use, and microparticles can outperform nanoparticles in specific instances. Here we demonstrate the ability of sedimentation to size-select ultrasmall (1–10 μm) nanoporous microparticles in common solvents. Size tunability is quantified for 1–24 h of sedimentation. Experimental values of settling times in ethanol and water are compared to those calculated using Stokes’ Law. Differences can arise due to particle agglomeration, internal gas generation and incomplete wetting. Air-dried and supercritically-dried pSi powders are shown to have, for example, their median diameter d (0.5) particle sizes reduced from 13 to 1 μm and from 20 to 3 μm, using sedimentation times of 6 and 2 h respectively. Such filtered microparticles also have much narrower size distributions and are hence suitable for administration in 27 gauge microneedles, commonly used in intravitreal drug delivery.

scholarly journals Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

2018 ◽  
Vol 90 ◽  
pp. 356-364 ◽  
Author(s):  
Maira Gaspar Tosato ◽  
Julie V. Maya Girón ◽  
Airton A. Martin ◽  
Vamshi Krishna Tippavajhala ◽  
Mónica Fernández Lorenzo de Mele ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Comparative Study ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems

One-Year Feasibility Study of Replenish MicroPump for Intravitreal Drug Delivery: A Pilot Study

2014 ◽  
Vol 3 (4) ◽  
pp. 1 ◽  
Author(s):  
Juan-Carlos Gutiérrez-Hernández ◽  
Sean Caffey ◽  
Walid Abdallah ◽  
Phillip Calvillo ◽  
Roberto González ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pilot Study ◽  
Feasibility Study ◽  
Intravitreal Drug Delivery ◽  
One Year

Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis

2018 ◽  
Vol 33 (4) ◽  
pp. 909-916 ◽  
Author(s):  
Rehab Mohamed Sobhi ◽  
Iman Sharaoui ◽  
Eman Ahmad El Nabarawy ◽  
Reham Shehab El Nemr Esmail ◽  
Rehab Aly Hegazy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vitamin C ◽  
Comparative Study ◽  
Co2 Laser ◽  
Topical Steroid ◽  
Fractional Co2 Laser ◽  
Macular Amyloidosis
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