scholarly journals Are Topical Steroids a Risk Factor for Tube Exposure in Glaucoma Drainage Devices?

2021 ◽  
Vol Volume 15 ◽  
pp. 1759-1761
Author(s):  
Alex M Ragan ◽  
Gavin Docherty ◽  
Andrew Crichton
Keyword(s):  
Risk Factor ◽  
Topical Steroids ◽  
Glaucoma Drainage Devices

scholarly journals Cushing Syndrome due to Inappropriate Corticosteroid Topical Treatment of Undiagnosed Scabies

2018 ◽  
Vol 3 (3) ◽  
pp. 82 ◽  
Author(s):  
Guadalupe Estrada-Chávez ◽  
Roberto Estrada ◽  
Daniel Engelman ◽  
Jesus Molina ◽  
Guadalupe Chávez-López
Keyword(s):  
Risk Factor ◽  
Topical Treatment ◽  
Cushing Syndrome ◽  
Important Risk Factor ◽  
Topical Steroids ◽  
Over The Counter ◽  
Inappropriate Use ◽  
Topical Corticosteroids ◽  
Lack Of Information

The uncontrolled sale of topical corticosteroids has become an important risk factor for the development of iatrogenic Cushing syndrome in children, especially in countries where medications are sold over the counter. This is exacerbated by the lack of information for both the patients and pharmacists. This report documents a series of eight cases of iatrogenic Cushing syndrome secondary to an inappropriate use of topical steroids, due to a misdiagnosis of scabies.

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

Sign in / Sign up

Export Citation Format

Share Document