scholarly journals Wide-field fundus autofluorescence corresponds to visual fields in chorioretinitis patients

2011 ◽  
pp. 1667 ◽  
Author(s):  
Marcus Kernt ◽  
Seidensticker ◽  
Neubauer ◽  
Wasfy ◽  
Stumpf ◽  
...  
Keyword(s):  
Fundus Autofluorescence ◽  
Visual Fields ◽  
Wide Field

scholarly journals Multimodal Imaging Characteristics of ADRP in a Family with p.Thr58Arg Substituted RHO Mutation

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Misty Ruppert ◽  
John Pyun ◽  
K. V. Chalam ◽  
David Sierpina
Keyword(s):  
Retinitis Pigmentosa ◽  
Multimodal Imaging ◽  
Fundus Autofluorescence ◽  
Visual Fields ◽  
Retinal Dystrophy ◽  
Young Patients ◽  
Photoreceptor Cells ◽  
Wide Field ◽  
Photoreceptor Layer ◽  
Imaging Characteristics

Background. Autosomal dominant retinitis pigmentosa (adRP) is a rare cause of progressive visual impairment in young patients and is frequently a result of RHO gene mutations. p.Thr58Arg rhodopsin mutation leads to misfolding of rhodopsin, subsequent accumulation in the endoplasmic reticulum, and leads to consecutive atrophy of photoreceptor cells through apoptosis. Materials and Methods. We describe multimodal imaging findings in a 58-year-old female with adRP due to a c.173 C > G, p.Thr58Arg rhodopsin mutation (confirmed on genotyping), including ultra-wide-field fundus autofluorescence (UWF-FAF), color scanning laser ophthalmoscopy, structural optical coherence tomography (OCT), OCT-angiography (OCT-A), electroretinography (ERG), and visual field testing (HVF). Additionally, we compare the patient’s phenotypic findings to those of her offspring, who was also affected by adRP. Results. The 58-year-old female and her son with symptoms of nyctalopia and decreased vision showed macular pigmentary changes in a bull’s-eye pattern along with bone spicules in periphery with retinal atrophy. Genotyping confirmed p.Thr58Arg rhodopsin mutation. Wide area of dystrophic retina was noted on UWF-FAF, along with corresponding atrophy of photoreceptor layer on OCT. OCTA revealed complete nonperfusion of the superficial capillary plexus in areas of retinal dystrophy. ERG revealed increased latency and decreased amplitudes; HVF revealed constriction of visual fields consistent with retinal findings. Conclusions. Multimodal imaging is extremely helpful in delineating the extent of retinal dystrophy and comparable to ERG for monitoring of progress in retinitis pigmentosa. Photoreceptor layer thickness (measured with OCT) strongly correlated with ERG and can be used as a secondary surrogate for monitoring the disease progress.

scholarly journals Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Satoru Kanda ◽  
Takumi Hara ◽  
Ryosuke Fujino ◽  
Keiko Azuma ◽  
Hirotsugu Soga ◽  
...  
Keyword(s):  
Visual Field ◽  
Significant Relationship ◽  
Fundus Autofluorescence ◽  
Univariate Analysis ◽  
Retrospective Chart Review ◽  
Mean Deviation ◽  
Wide Field ◽  
The Mean ◽  
The Relationship ◽  
Field Imaging

AbstractThis study aimed to investigate the relationship between autofluorescence (AF) signal measured with ultra-wide field imaging and visual functions in patients with cone-rod dystrophy (CORD). A retrospective chart review was performed for CORD patients. We performed the visual field test and fundus autofluorescence (FAF) measurement and visualized retinal structures with optical coherence tomography (OCT) on the same day. Using binarised FAF images, we identified a low FAF area ratio (LFAR: low FAF/30°). Relationships between age and logMAR visual acuity (VA), central retinal thickness (CRT), central choroidal thickness (CCT), mean deviation (MD) value, and LFAR were investigated. Thirty-seven eyes of 21 CORD patients (8 men and 13 women) were enrolled. The mean patient age was 49.8 years. LogMAR VA and MD were 0.52 ± 0.47 and − 17.91 ± 10.59 dB, respectively. There was a significant relationship between logMAR VA and MD (p = 0.001). LogMAR VA significantly correlated with CRT (p = 0.006) but not with other parameters. Conversely, univariate analysis suggested a significant relationship between MD and LFAR (p = 0.001). In the multivariate analysis, LFAR was significantly associated with MD (p = 0.002). In conclusion, it is useful to measure the low FAF area in patients with CORD. The AF measurement reflects the visual field deterioration but not VA in CORD.

Wide-Field Fundus Autofluorescence Imaging of Retinitis Pigmentosa

Ophthalmology ◽  
2013 ◽  
Vol 120 (9) ◽  
pp. 1827-1834 ◽  
Author(s):  
Akio Oishi ◽  
Ken Ogino ◽  
Yukiko Makiyama ◽  
Satoko Nakagawa ◽  
Masafumi Kurimoto ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Fundus Autofluorescence ◽  
Wide Field ◽  
Autofluorescence Imaging

Advanced Pericentral Hydroxychloroquine Retinopathy in an Asian Woman

2019 ◽  
Vol 4 (2) ◽  
pp. 148-151
Author(s):  
Neil Sheth ◽  
Tara Schaab ◽  
Rukhsana G. Mirza
Keyword(s):  
Fundus Autofluorescence ◽  
Visual Fields ◽  
Screening Methods ◽  
Asian Woman ◽  
Fundus Examination ◽  
Asian Origin ◽  
Hydroxychloroquine Retinopathy ◽  
Ophthalmologic Examination ◽  
Serial Images

Purpose: This case report describes the unique clinical attributes of pericentral retinopathy associated with hydroxychloroquine (Plaquenil) use in patients of Asian ancestry. Methods: A complete ophthalmologic examination including optical coherence tomography, fundus autofluorescence, and Humphrey visual fields was performed. Serial images were obtained at subsequent follow-up appointments. Results: A dilated fundus examination demonstrated extensive bilateral parafoveal and perifoveal atrophy extending past the superior and inferior arcades as well as central macular preservation. Fundus autofluorescence exhibited prominent pericentral hypoautofluorescence. Conclusions: The distinct variant of pericentral hydroxychloroquine retinopathy has become increasingly recognized in patients of Asian origin. It is important for ophthalmologists to distinguish this pattern and consider modifying screening methods.

Use of Wide-Field Fundus Camera, Fundus Autofluorescence, and OCT in Cases of Pigmented Paravenous Retinochoroidal Atrophy

2018 ◽  
Vol 2 (1) ◽  
pp. 79-81 ◽  
Author(s):  
Seiji Takagi ◽  
Yasuhiko Hirami ◽  
Masayo Takahashi ◽  
Shogo Yamamoto ◽  
So Goto ◽  
...  
Keyword(s):  
Fundus Autofluorescence ◽  
Wide Field ◽  
Fundus Camera ◽  
Pigmented Paravenous Retinochoroidal Atrophy

Clinical Signs, Imaging, Diagnosis and Differential Diagnosis of Rhegmatogenous Retinal Detachment

2019 ◽  
pp. 154-162
Keyword(s):  
Differential Diagnosis ◽  
Retinal Detachment ◽  
Ultrasound Imaging ◽  
Rhegmatogenous Retinal Detachment ◽  
Fundus Autofluorescence ◽  
Clinical Signs ◽  
Vitreous Hemorrhage ◽  
Fundus Photography ◽  
Visual Field Defects ◽  
Wide Field

Photopsia, floaters, visual field defects, loss in visual acuity, periocular pain, and dyschromatopsia are symptoms of rhegmatogenous retinal detachment in which early signs are Weiss ring, pigmented cells in anterior vitreous (tobacco dust sign), a general decrease in intraocular pressure and retinal detachment in a convex configuration. On the other hand, the demarcation line, secondary retinal cysts, and proliferative vitreoretinopathy are some of the late findings of detachment. Imaging of the retina is crucial in rhegmatogenous retinal detachment. Fundus photography, wide-field imaging systems, optical coherence tomography, and fundus autofluorescence tomography are beneficial for documentation and monitoring progression. Ultrasound imaging, computerized tomography, and magnetic resonance imaging may be helpful when the retina cannot be visualized in cases like vitreous hemorrhage and dense cataract. Diagnosis can be made with indirect ophthalmoscopy with indentation, and ultrasound imaging in an opaque medium. Differential diagnosis of rhegmatogenous retinal detachment is exudative and tractional detachment, as well as lesions that can mimic retinal detachment such as retinoschisis, intraretinal macrocysts, choroidal detachment, vitreous opacities and white with or without pressure lesions.

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