scholarly journals Efficacy and Safety of VisuEvo® and Cationorm® for the Treatment of Evaporative and Non-Evaporative Dry Eye Disease: A Multicenter, Double-Blind, Cross-Over, Randomized Clinical Trial

2020 ◽  
Vol Volume 14 ◽  
pp. 1651-1663
Author(s):  
Paolo Fogagnolo ◽  
Chiara Quisisana ◽  
Anna Caretti ◽  
Daniele Marchina ◽  
Michele Dei Cas ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Evaporative Dry Eye

Autologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease: a double‐blind randomized clinical trial

2021 ◽  
Author(s):  
Marina Rodríguez Calvo‐de‐Mora ◽  
Cayetano Domínguez‐Ruiz ◽  
Francisco Barrero‐Sojo ◽  
Gustavo Rodríguez‐Moreno ◽  
Cristina Antúnez Rodríguez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Umbilical Cord ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Double Blind

scholarly journals Acupuncture at a Single Acupoint, BL1 (Jingming), Compared to Artificial Tears in Moderate to Severe Dry Eye Disease: A Randomized Controlled Trial

2021 ◽  
Author(s):  
xue zhang ◽  
Bo Zhang ◽  
Siyang Peng ◽  
Guoliang Zhang ◽  
Jumei Ma ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dry Eye ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Artificial Tears ◽  
Artificial Tear ◽  
Randomized Controlled

Abstract BackgroundThe global incidence of dry eye disease (DED) is very high. DED seriously affects the quality of life of patients; however, the current curative effect of medicine for moderate to severe DED is poor. This randomized clinical trial was planned to investigate the effect of acupuncture compared with artificial tears on moderate to severe DED.MethodsA randomized clinical trial was performed at 2 hospitals in China. 120 DED patients were randomly equally divided into an acupuncture and an artificial tear group. Either acupuncture or artificial tears was performed for an 8-week period, and a 32-week follow-up was performed. The primary outcome measure was the Schirmer-I test (SIT) value. The secondary outcome measures included the numerical rating scale (NRS) for improvement in ocular symptoms, the ocular surface disease index (OSDI), the tear-film break-up time (TBUT), corneal fluorescein staining (CFS), and acupuncture acceptability. Adverse events also were monitored and documented.ResultsFor the primary outcome, the mean changes in the SIT values were significantly different between the acupuncture (5.75 [2.53‒9.75]) and artificial tear (0.52 [-1.18‒2.46]) groups at week 8 (P = 0.01). The OSDI decreased by -16.14 (-35.40‒16.30) and − 7.65 (-19.25‒15.05) from baseline to week 8 in the acupuncture and artificial tear groups, respectively (P < 0.05). A significant decrease was found in the NRS score for eye dryness, eye pain, and blurred vision in the acupuncture group, as compared to the artificial tear group. However, the change in the average symptom NRS score, TBUT, and CFS did not differ significantly at week 8. Five cases experienced acupuncture-related adverse events.ConclusionsThis randomized clinical trial found that acupuncture at a single acupoint, BL1, significantly promoted tear secretion and improved multiple eye discomfort symptoms. Acupuncture showed greater benefits than artificial tears for moderate to severe DED. However, the study findings warrant verification.Trial registrationRegistration number: ChiCTR1800015831. Name of trial registry: Efficacy and safety of acupuncture in the treatment of moderate to severe dry eye disease: a randomized controlled trial.

scholarly journals A Comparison of Efficacy and Safety of Two Lipid-Based Lubricant Eye Drops for the Management of Evaporative Dry Eye Disease

2020 ◽  
Vol Volume 14 ◽  
pp. 1665-1673 ◽  
Author(s):  
Gary Jerkins ◽  
Jack V Greiner ◽  
Louis Tong ◽  
Jacqueline Tan ◽  
Joseph Tauber ◽  
...  
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Efficacy And Safety ◽  
Evaporative Dry Eye

scholarly journals Treatment of Dry Eye With Intracanalicular Injection of Hydroxybutyl Chitosan: A Prospective Randomized Clinical Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Tong Lin ◽  
Wushuang Wang ◽  
Yang Lu ◽  
Lan Gong
Keyword(s):  
Clinical Trial ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Phenol Red ◽  
Efficacy And Safety ◽  
Fluorescence Staining ◽  
Meniscus Height ◽  
Tear Meniscus ◽  
Tear Meniscus Height

Background: Punctal/intracanalicular plugs on the market nowadays are all designed before clinical use in treating dry eye disease (DED). To provide an individualized lacrimal drainage system occlusion method and reduce the complications, we developed a “liquid plug” strategy by intracanalicular injection of hydroxybutyl chitosan (HBC) solution, a thermosensitive, phase-changing biomaterial. This study evaluated the efficacy and safety of the HBC plug in treating dry eye disease by comparing it with the VisiPlug absorbable intracanalicular plug.Methods: A monocenter, randomized, controlled clinical trial was performed. Fifty patients with DED were randomized 1:1 to undergo either the HBC injection treatment or the VisiPlug treatment. Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), corneal fluorescence staining (CFS), tear meniscus height (TMH), and phenol red thread test were evaluated at Day 0 (baseline, before treatment) and Weeks 1, 4, and 12.Results: The two groups had a balanced baseline of age, gender, and DED-related characteristics. Both occlusion methods could relieve the symptoms and signs of DED. Significant improvement was found in OSDI, phenol red thread test, and tear meniscus height (P &lt; 0.05 compared to baseline) but not in corneal fluorescence staining and tear break-up time (P &gt; 0.05). There is no statistically significant difference between HBC injection and VisiPlug at Weeks 1 and 4 (P &gt; 0.05). However, at week 12, the HBC injection was not as effective as the VisiPlug in maintaining phenol red thread test (HBC: 5.35 ± 3.22 mm, VisiPlug: 8.59 ± 4.35 mm, P = 0.009) and tear meniscus height (HBC: 206.9 ± 47.95 μm, VisiPlug: 242.59 ± 60.30 μm, P = 0.041). The numbers of ocular adverse events were relatively low in both groups.Conclusions: The HBC injection showed similar efficacy and safety compared to VisiPlug. The intracanalicular injection of HBC solution proves to be a promising, individualizing method to treat DED.Clinical Trial Registration: This study is registered with the Chinese Clinical Trial Registry (https://www.chictr.org.cn/enindex.aspx), Identifier: ChiCTR1800016603.

Evaluation of Evaporative Dry Eye Disease Using Thermal Images of Ocular Surface Regions with DWT and Gabor Transform

2017 ◽  
pp. 359-375
Author(s):  
Vidya K. Sudarshan ◽  
Joel E. W. Koh ◽  
U. Rajendra Acharya ◽  
Jen Hong Tan ◽  
Muthu Rama Krishnan Mookiah ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Gabor Transform ◽  
Thermal Images ◽  
Evaporative Dry Eye

A Randomized, Placebo-Controlled Phase II Clinical Trial of 0.01% or 0.02% Cyclosporin A with 3% Trehalose in Patients with Dry Eye Disease

2021 ◽  
Vol 37 (1) ◽  
pp. 4-11
Author(s):  
Jeongah Shin ◽  
Chang Rae Rho ◽  
Joon Young Hyon ◽  
Tae-Young Chung ◽  
Kyung Chul Yoon ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cyclosporin A ◽  
Phase Ii ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Phase Ii Clinical Trial ◽  
Eye Disease
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