scholarly journals Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

2019 ◽  
Vol Volume 13 ◽  
pp. 1157-1163 ◽  
Author(s):  
L Caretti ◽  
A La Gloria Valerio ◽  
R Piermarocchi ◽  
G Badin ◽  
G Verzola ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Film Instability

scholarly journals Evaluation of protection against desiccation with different artificial tears containing 0.1%-0.3% hyaluronic acid in experimental dry eye model

2020 ◽  
Author(s):  
Fatma Ahmed ◽  
Frank Tost ◽  
Rico Großjohann ◽  
Carmen Wolke ◽  
Uwe Lendeckel
Keyword(s):  
Hyaluronic Acid ◽  
Cell Line ◽  
Dry Eye ◽  
Exposure Time ◽  
Ionic Composition ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Epithelial Cell Line ◽  
Film Instability

Abstract Background: Tear film instability, hyperosmolarity, ocular surface inflammation, apoptosis and neuro-sensory abnormalities are causes of dry eye. Lubricant target tear film instability, the most effective agent for tear film stabilization being Sodium Hyaluronate 0.1 -0.3%. Sodium Hyaluronate is suggested to be protective for epithelium in dry eye. To test this hypothesis, this study was performed in vitro with commercially available solutions containing hyaluronic acid (HA) in concentrations ranging from 0.1 to 0.3%. To evaluate the desiccation protection capability of different Sodium Hyaluronate 0.1 to 0.3%, we employed a reproducible in vitro cell culture system. Methods: Conjunctival (Chang 1-5c-4) and corneal cells (pRSV-T 2.040) were cultivated under standard conditions. Under confluent cell growth cells, conjunctival epithelial cell line Chang 1-5c-4 and the corneal cell line 2.040 pRSV-T were wetted for 20 min with five commercial ophthalmic solutions and one agent in trial phase (sample 1: 0.1% HA; sample 2: 0.3% HA; sample 3: 0.15% HA, 2% dexpanthenol, sodium chloride; sample 4: 0.1% HA; sample 5: 0.2% HA; sample 6: unknown, PBS as negative control, unsupplemented medium as positive control). After 20 minutes cells were exposed to continuous air flow for 0, 15, 30 and 45 minutes. Assessment of viable cells was performed by alamarBlue® assay and LIVE/DEAD® Viability/ Cytotoxicity Kit. Results: It has been shown that both cell lines showed different response to protection by the tested solutions. Greatest protection was observed at 15 minutes with most agents. Best results in protection from desiccation was assessed with sample 2 even at maximum exposure time at 45 minutes. Sample 2 showed an average survival rate of 91% at 45 minutes exposure time, whereas no significant amount of vital cells were detected after application with sample 6. Sample 6 was the only substance that presented with early significant cell loss at 0 and 15 minutes by 35%. Conclusions: Higher concentration of Hyaluronate acid with 0.3% and an ionic composition close to the normal tearfluid seem to provide the best protective effect against desiccation in experimental dry eye.

scholarly journals Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Takashi Itokawa ◽  
Yukinobu Okajima ◽  
Takashi Suzuki ◽  
Tatsuhiko Kobayashi ◽  
Yuto Tei ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Regression Analysis ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Tear Film ◽  
Blink Rate ◽  
Film Stability ◽  
Tear Film Stability ◽  
Functional Visual Acuity ◽  
Film Group

Purpose. To investigate the association among the ocular surface temperature (OST), tear film stability, functional visual acuity (FVA), and blink rate in patients after cataract surgery. Methods. We recruited 98 eyes of 69 patients (mean age, 73.7 ± 5.2 years) 1 month after phacoemulsification with implantation of acrylic intraocular lenses and assessed slit-lamp microscopy, corrected distance VA, FVA, noninvasive tear breakup time (NIBUT), and OST. We defined the changes in the OST from 0 to 10 seconds after eye opening as the ΔOST. We measured the FVA and blink rate using the FVA measurement system. We divided the patients into two groups based on tear film stability: stable tear film (NIBUT, >5.0 seconds) and unstable tear film (NIBUT, ≤5.0 seconds). We evaluated the differences between the two groups and the association between the blink rate and other clinical parameters. Results. The unstable tear film group (56 eyes) had significantly (p<0.0001, unpaired t-test) shorter NIBUTs than the stable tear film group (42 eyes). The ΔOSTs and blink rates were significantly (p<0.0001) higher in the unstable tear film group than in the stable group. Linear single regression analysis showed that the ΔOST (r = −0.430, p<0.0001), NIBUT (r = −0.392, p<0.0001), and gender (r = −0.370, p=0.0002) were correlated significantly with the blink rate. Multiple regression analysis showed that the ΔOST independently contributed to the blink rate. Conclusions. The frequency of blinks is associated with tear film stability in patients after cataract surgery. The blink rate may be useful for evaluating the tear film stability in clinical practice. The ΔOST should be an important contributing factor to the blink rate. [This trial is registered with UMIN000026970].

Changes in the tear film and ocular surface after cataract surgery

2012 ◽  
Vol 56 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Taehoon Oh ◽  
Younhea Jung ◽  
Dongjin Chang ◽  
Jaeryun Kim ◽  
Hyunseung Kim
Keyword(s):  
Cataract Surgery ◽  
Ocular Surface ◽  
Tear Film

scholarly journals Zdravljenje glavkoma in suho oko

2016 ◽  
Vol 85 (4) ◽  
Author(s):  
Barbara Cvenkel
Keyword(s):  
Ocular Surface ◽  
Clinical Signs ◽  
Tear Film ◽  
Signs And Symptoms ◽  
Surface Damage ◽  
Eye Drops ◽  
Film Instability ◽  
Asymptomatic Patients

Patients with glaucoma have increased prevalence of dry eye (DE) compared to age-matched population without glaucoma. Clinical presentation of DE varies among individuals and may significantly reduce quality of life. The onset and deterioration of DE is caused by the toxic-inflammatory effects of preservatives in eye drops, active substance itself, and added, pharmacologically inactive substances or excipients. Ocular surface changes most frequently include superficial punctate keratitis, tear film instability, and allergic reactions. Despite the lack of symptoms, clinical signs may indicate ocular surface damage. Discordance between signs and symptoms is partly caused by decreased corneal sensitivity induced by neurotoxicity of the preservative benzalkonium chloride (BAK). Therefore, it is important to evaluate ocular surface before initiating glaucoma therapy and during follow-up also in asymptomatic patients. Preservative-free and/or BAK-free therapy is indicated in patients with severe DE and allergy to preservatives, and recommended in patients with DE of moderate severity, blepharitis, in symptomatic patients, before filtering surgery to reduce preoperative inflammation, in those with moderate fluorescein staining of grade 2 on Oxford scheme, and reduced tear film break-up time.

scholarly journals Analysis of tear film spatial instability for pediatric myopia under treatment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wan-Hua Cho ◽  
Po-Chiung Fang ◽  
Hun-Ju Yu ◽  
Pei-Wen Lin ◽  
Hsiu-Mei Huang ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Corneal Surface ◽  
Myopia Progression ◽  
Spatial Instability ◽  
Film Instability ◽  
Treatment Naïve ◽  
Break Up ◽  
High Order Aberrations ◽  
Myopia Control

Abstract In Taiwan, the prevalence of myopia in children between 6 and 18 years old is over 80%, and high myopia accounts for over 20%, which turned out to be in the leading place worldwide. Orthokeratology and low-dose atropine are proven treatments to reduce myopia progression, though the potential corneal disturbances remain an issue in young populations. The alteration of the tear film is widely discussed but there is no consensus to date, so we aim to investigate the tear film spatial instability in children with myopia control using atropine or orthokeratology. Thirty-eight treatment-naïve participants and 126 myopic children under treatments were enrolled. The ocular surface homeostasis, spatial distribution of tear break-up, and high-order aberrations (HOAs) of the corneal surface were assessed. We found out that myopic children treated with either atropine or orthokeratology showed ocular surface homeostasis similar to that in treatment-naïve children. Nevertheless, children treated with orthokeratology presented higher HOAs (p < 0.00001) and a tendency of the first tear break-up zone at the inner half of the cornea (p = 0.04). This unique spatial instability of the tear film associated with myopia treatment might provide a more focused way of monitoring the pediatric tear film instability.

scholarly journals A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sangyoon Kim ◽  
Jonghoon Shin ◽  
Ji Eun Lee
Keyword(s):  
Multivariate Analysis ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Test Score ◽  
Surgical Techniques ◽  
Sodium Hyaluronate ◽  
Ophthalmic Solution ◽  
Disease Index ◽  
Lipid Layer ◽  
Ocular Surface Disease Index

AbstractThere is still no established therapeutic solution for postoperative Dry Eye Syndrome (DES) after cataract surgery, in spite of progress in surgical techniques. Diquafosol tetrasodium (DQS), a recently developed ophthalmic solution, has been reported to be effective in DES, but no study evaluated post-cataract surgery lipid layer thickness (LLT) changes in healthy patients who used DQS postoperatively. We randomly divided participants into two groups; the DQS group was treated six times daily with DQS after cataract surgery, and the sodium hyaluronate (HA) group was treated with HA in the same way. Throughout study period, the DQS group showed significantly higher tear break up time (TBUT) and LLT than HA group. In multivariate analysis, better preoperative TBUT, Schirmer’s I test score, ocular surface disease index (OSDI) score, and LLT were significantly associated with improved postoperative outcomes in each parameter. Also, the postoperative use of DQS served as an independent parameter of better TBUT, OSDI score, and LLT in postoperative 15 weeks. Treatment with 3% DQS following cataract surgery showed more improvement in TBUT and LLT, compared with 0.1% HA. Improving TBUT and LLT preoperatively and using 3% DQS postoperatively, could be a reliable choice for managing DES after cataract surgery.Trial Registration: ISRCTN registry with ISRCTN 18755487.

scholarly journals Dry eye disease and pterygium

2020 ◽  
Vol 34 (4) ◽  
Author(s):  
Munir Amjad Baig ◽  
Rabeeya Munir
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Cross Sectional Study ◽  
Eye Disease ◽  
Sectional Study ◽  
Cross Sectional ◽  
Physical Conditions ◽  
Film Instability ◽  
Surface Changes

Pterygium is a common external eye disease in general population which progresses slow but has a little effect on vision.   Purpose: To know the tear film and ocular surface changes with pterygium.   Study Design:A descriptive cross sectional study     Place and duration of study: Federal Government Services Hospital Islamabad during Jun.2013 to Dec.   Material and methods:Dry eye questionnaire (DEQ-6) was administered by a trained researcher and DE tests were performed in all 256 willing subjects (136 with pterygium+120control) age 30-76years,by a single surgeon under same physical conditions after taking the consent and approval from Hospital Ethical committee.  Diagnosis was made on presence of both symptoms and tear film parameters. Statistical analysis was by simple percentages.   Results:DE was found in 73(53.7%) of the pterygium cases and 28(23.5%) of the normal patients. In this study, 55(40.5%) were symptomatic, defined as reporting 1 or more DE symptoms often or all of the time. 53(39%) showed corneal fluorescein staining CFS and 69(51%) showed lid plugging/mucous threads in both groups Of 136 eyes with pterygium, [male 91 (67%) female 45(33%)], 50(37.5%) showed normal tear film and 86(62.5%) showed deranged functions whereas among 120 control eyes,[Male 73(61%) female 47(39%)],86(72.3%) were normal and 34(27.7%)had abnormal functions.These values were reduced indicating changed tear film in these patients. Conclusion:Pterygium disturbs tear functions causing dry eye like symptoms. Key-words: Dry eye, pterygium, tear film instability, ocular surface     

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