scholarly journals Prefilled syringes for intravitreal drug delivery

2019 ◽  
Vol Volume 13 ◽  
pp. 701-706 ◽  
Author(s):  
Thérèse M Sassalos ◽  
Yannis M Paulus
Keyword(s):  
Drug Delivery ◽  
Intravitreal Drug Delivery ◽  
Prefilled Syringes

scholarly journals A Gentle Sedimentation Process for Size-Selecting Porous Silicon Microparticles to Be Used for Drug Delivery Via Fine Gauge Needle Administration

Silicon ◽  
2020 ◽  
Author(s):  
Elida Nekovic ◽  
Catherine J. Storey ◽  
Andre Kaplan ◽  
Wolfgang Theis ◽  
Leigh T. Canham
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Porous Silicon ◽  
Particle Sizes ◽  
Size Distributions ◽  
Particle Agglomeration ◽  
Gas Generation ◽  
Intravitreal Drug Delivery ◽  
Median Diameter ◽  
Experimental Values

AbstractBiodegradable porous silicon (pSi) particles are under development for drug delivery applications. The optimum particle size very much depends on medical use, and microparticles can outperform nanoparticles in specific instances. Here we demonstrate the ability of sedimentation to size-select ultrasmall (1–10 μm) nanoporous microparticles in common solvents. Size tunability is quantified for 1–24 h of sedimentation. Experimental values of settling times in ethanol and water are compared to those calculated using Stokes’ Law. Differences can arise due to particle agglomeration, internal gas generation and incomplete wetting. Air-dried and supercritically-dried pSi powders are shown to have, for example, their median diameter d (0.5) particle sizes reduced from 13 to 1 μm and from 20 to 3 μm, using sedimentation times of 6 and 2 h respectively. Such filtered microparticles also have much narrower size distributions and are hence suitable for administration in 27 gauge microneedles, commonly used in intravitreal drug delivery.

One-Year Feasibility Study of Replenish MicroPump for Intravitreal Drug Delivery: A Pilot Study

2014 ◽  
Vol 3 (4) ◽  
pp. 1 ◽  
Author(s):  
Juan-Carlos Gutiérrez-Hernández ◽  
Sean Caffey ◽  
Walid Abdallah ◽  
Phillip Calvillo ◽  
Roberto González ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pilot Study ◽  
Feasibility Study ◽  
Intravitreal Drug Delivery ◽  
One Year

scholarly journals A sustained intravitreal drug delivery system with remote real time monitoring capability

2015 ◽  
Vol 24 ◽  
pp. 309-321 ◽  
Author(s):  
Huiyuan Hou ◽  
Alejandra Nieto ◽  
Akram Belghith ◽  
Kaihui Nan ◽  
Yangyang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Real Time Monitoring ◽  
Intravitreal Drug Delivery

scholarly journals Evaluation of polyesteramide (PEA) and polyester (PLGA) microspheres as intravitreal drug delivery systems in albino rats

Biomaterials ◽  
2017 ◽  
Vol 124 ◽  
pp. 157-168 ◽  
Author(s):  
Tobias Peters ◽  
Seong-Woo Kim ◽  
Vinicius Castro ◽  
Krunoslav Stingl ◽  
Torsten Strasser ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Albino Rats ◽  
Plga Microspheres ◽  
Intravitreal Drug Delivery

scholarly journals Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy

2017 ◽  
Vol 103 ◽  
pp. 27-35 ◽  
Author(s):  
Thomas F Martens ◽  
Karen Peynshaert ◽  
Thaís Leite Nascimento ◽  
Elias Fattal ◽  
Marcus Karlstetter ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Intravitreal Drug Delivery ◽  
Retinal Gene Therapy ◽  
Hyaluronic Acid Binding

Experimental Intravitreal Drug Delivery for Retinal Disease

1992 ◽  
pp. 231-242
Author(s):  
W. R. Freeman ◽  
C. A. Wiley ◽  
K. Assil ◽  
R. Gariano ◽  
A. Listhaus ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Retinal Disease ◽  
Intravitreal Drug Delivery
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