scholarly journals Blood pressure, ocular perfusion pressure and open-angle glaucoma in patients with systemic hypertension

2018 ◽  
Vol Volume 12 ◽  
pp. 1511-1517 ◽  
Author(s):  
Erika Cantor ◽  
Fabián Méndez ◽  
Carlos Rivera ◽  
Andrés Castillo ◽  
Alexander Martínez-Blanco
Keyword(s):  
Blood Pressure ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Systemic Hypertension ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion

Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore Epidemiology of Eye Diseases study

2018 ◽  
Vol 102 (10) ◽  
pp. 1402-1406 ◽  
Author(s):  
Yih-Chung Tham ◽  
Sing-Hui Lim ◽  
Preeti Gupta ◽  
Tin Aung ◽  
Tien Y Wong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Eye Diseases ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Relevant Covariates

ObjectiveTo elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population.MethodsParticipants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria. Logistic regression analyses with generalised estimating equation models were performed and used to account for correlation between eyes.ResultsA total of 9877 participants (19 587 eyes), including 213 POAG cases (293 eyes) were included. Eyes with lowest quartile levels of systolic OPP (SOPP <110 mm Hg) were 1.85 times (95% CI 1.16 to 2.95) likely to have POAG, compared with eyes with mid-range SOPP levels (123–137 mm Hg; third quartile), after adjusting for relevant covariates and IOP. Consistently, we found that lowest quartile of systolic BP (SBP <124 mm Hg) was 1.69 times (95% CI 1.08 to 2.66) likely to have POAG, compared with mid-range SBP levels (138–153 mm Hg; third quartile). Furthermore, the effect of lower SBP on POAG was more pronounced in eyes with IOP ≥21 mm Hg (OR 3.90; 95% CI 1.24 to 12.30). Both the mean and diastolic profiles of OPP and BP were not significantly associated with POAG, after adjusting for relevant covariates and IOP.ConclusionsIn this population-based sample of nearly 10 000 Asian individuals, we showed that low SOPP was associated with POAG. This association was potentially in part secondary to low SBP and high IOP. Our findings provide further clarity on the roles of OPP surrogates and BP profiles in POAG.

scholarly journals The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hye Jin Chung ◽  
Hyung Bin Hwang ◽  
Na Young Lee
Keyword(s):  
Blood Pressure ◽  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Increased Risk ◽  
Low Blood Pressure ◽  
The Relationship

Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also been identified as risk factors and can lead to hypoperfusion of the optic nerve head and thus may play an important role in the pathogenesis and progression of POAG. The results of the present study suggest that both high and low blood pressure (BP) are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure (OPP) and subsequent ischemic injury. The relationship between IOP, OPP, and BP suggests that the relationship between BP and glaucoma progression is U-shaped.

scholarly journals Correlation of open-angle glaucoma and ocular perfusion pressure in hypertensive individuals

2020 ◽  
Vol 8 (1) ◽  
pp. 5
Author(s):  
Rekha Khandelwal ◽  
Rachit Khandelwal ◽  
Dhananjay Raje ◽  
Deepa Kumar ◽  
Anand Rathi
Keyword(s):  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion

Ocular perfusion pressure - a risk factor for open-angle glaucoma or a statistical artifact?

2012 ◽  
Vol 90 ◽  
pp. 0-0
Author(s):  
NM JANSONIUS ◽  
WD RAMDAS ◽  
RCW WOLFS ◽  
A HOFMAN ◽  
PTVM DE JONG ◽  
...  
Keyword(s):  
Risk Factor ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Statistical Artifact

scholarly journals Effect of mean ocular perfusion pressure on primary open angle glaucoma

2018 ◽  
Vol 11 (4) ◽  
pp. 286-290
Author(s):  
Pallab Kumar Sen ◽  
Nazneen Khan ◽  
Md. Shafiqul Islam
Keyword(s):  
Odds Ratio ◽  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
The Mean ◽  
The Right

Primary open angle glaucoma is the most common form of glaucoma and it remains asymptomatic until the late stage of the disease. The purpose of this study is to compare the mean ocular perfusion pressure with the primary open angle glaucoma. A total of 60 study subjects were divided into two following groups: a) newly diagnosed patients with primary open angle glaucoma (case) and b) age and sex-matched healthy volunteers (control). The intraocular pressure and blood pressure were measured 3 hourly from 8:00 am to 11:00 pm. The mean ocular perfusion pressure of the right eyes in untreated primary open angle glaucoma was 39.9 ± 7.5 mm Hg whereas it was 47.7 ± 7.7 mm Hg in the control. The odds ratio was 6.6 (95% CI, 2.1-20.5; p=0.002). The right eyes of untreated primary open angle glaucoma had 6.6 times more risk compared to the control group. The mean ocular perfusion pressure of left eyes in untreated primary open angle glaucoma was 39.9 ± 7.5 mm Hg and 48.6 ± 4.0 mm Hg in the control group. The odds ratio was 5.7 (95% CI, 1.8-17.5; p=0.004). The left eyes of untreated primary open angle glaucoma had 5.7 times more risk compared to control group. The findings revealed the evidence of vascular mechanism in glaucoma pathogenesis: Reduction of mean ocular perfusion pressure ≤48 mm Hg, may lead to daily repetitive ischemic insult to the optic nerve.

scholarly journals Author Response: Incident Open-Angle Glaucoma and Ocular Perfusion Pressure

2012 ◽  
Vol 53 (1) ◽  
pp. 150
Author(s):  
Wishal D. Ramdas ◽  
Roger C. W. Wolfs ◽  
Albert Hofman ◽  
Paulus T. V. M. de Jong ◽  
Johannes R. Vingerling ◽  
...  
Keyword(s):  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Author Response ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion

scholarly journals Circadian Variation of Ocular Perfusion Pressure in Primary Open Angle Glaucoma- A Cross-sectional Study

2021 ◽  
Author(s):  
Raheeba Pakeer Muhammed ◽  
Neeta Sidhan ◽  
Beena Thankappan
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Circadian Variation ◽  
Cross Sectional Study ◽  
Open Angle ◽  
Sectional Study ◽  
Ocular Perfusion Pressure ◽  
Cross Sectional ◽  
Ocular Perfusion

Introduction: Various haemodynamic factors have been implicated as pathophysiological mechanisms in Primary Open Angle Glaucoma (POAG) other than raised Intraocular Pressure (IOP). However, the exact relationship still remains unclear. Aim: To examine the circadian pattern of Blood Pressure (BP), IOP and Ocular Perfusion Pressure (OPP) with the aim of understanding their relationships in a cohort of patients with POAG. Materials and Methods: A cross-sectional study was conducted in which 44 cases of newly diagnosed, non-hypertensive patients with POAG were enrolled and categorised based on the severity of glaucoma. Recording of BP and IOP were done every 4th hourly during a 24 hour hospital stay. The Mean OPP (MOPP) was calculated as 2/3×Mean Arterial Pressure (MAP)-IOP. Systolic OPP (SOPP) was calculated as Systolic BP-IOP and Diastolic OPP (DOPP) was calculated as Diastolic BP-IOP. The diurnal, nocturnal and 24 hour fluctuations were derived from the difference between the highest and lowest values within each period. Data was analysed using Statistical Package for the Social Sciences (SPSS) version 16.0. Univariate and multivariate regression analysis of the variables with age and severity of POAG were performed Results: Significant positive correlation of the nocturnal fluctuations in MAP (r=0.533), SOPP (r=0.835), DOPP (r =0.768), MOPP (r=0.685) and 24 hour fluctuation in MOPP (r=0.636) were noted with severity of glaucoma on multivariate analysis. No significant correlation of these parameters with age was noted on multivariate analyses. Conclusion: Nocturnal dip in OPP was an important observation among patients with POAG, potentially contributing to its pathophysiology.

Topical medical therapy and ocular perfusion pressure in open angle glaucoma: a systematic review and meta-analysis

2019 ◽  
Vol 35 (8) ◽  
pp. 1421-1431 ◽  
Author(s):  
George Rennie ◽  
Angus Wilkinson ◽  
Andrew White ◽  
Marinella Ruospo ◽  
Armando Teixeira-Pinto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Medical Therapy ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion
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