Dose uniformity of topical corticosteroid preparations: difluprednate ophthalmic emulsion 0.05% versus branded and generic prednisolone acetate ophthalmic suspension 1%

Dose uniformity of loteprednol etabonate ophthalmic gel (0.5%) compared with branded and generic prednisolone acetate ophthalmic suspension (1%)

Clinical Ophthalmology ◽

10.2147/opth.s55004 ◽

2013 ◽

pp. 23 ◽

Cited By ~ 1

Author(s):

Zora Marlowe ◽

Stephen Davio

Keyword(s):

Prednisolone Acetate ◽

Loteprednol Etabonate ◽

Dose Uniformity ◽

Ophthalmic Suspension

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Dose Uniformity of Loteprednol Etabonate (Submicron) Ophthalmic Gel 0.38% Compared with Prednisolone Acetate Ophthalmic Suspension 1%

Ophthalmology and Therapy ◽

10.1007/s40123-021-00445-z ◽

2021 ◽

Author(s):

Zora T. Marlowe ◽

Megan E. Cavet ◽

Martin J. Coffey

Keyword(s):

Prednisolone Acetate ◽

Loteprednol Etabonate ◽

Dose Uniformity ◽

Ophthalmic Suspension

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Topical Diclofenac Sodium Compared with Prednisolone Acetate after Phacoemulsification-Lens Implant Surgery

European Journal of Ophthalmology ◽

10.1177/112067219700700306 ◽

1997 ◽

Vol 7 (3) ◽

pp. 236-240 ◽

Cited By ~ 12

Author(s):

T.A. Demco ◽

H. Sutton ◽

C.J. Demco ◽

P. Sunder Raj

Keyword(s):

Subjective Evaluation ◽

Diclofenac Sodium ◽

Ophthalmic Solution ◽

Applanation Tonometry ◽

Posterior Chamber ◽

Prednisolone Acetate ◽

Local Tolerance ◽

Posterior Chamber Lens ◽

Significant Difference ◽

Ophthalmic Suspension

Purpose. This study was performed to compare the efficacy, safety and tolerability of diclofenac sodium 0.1 % ophthalmic solution with that of prednisolone acetate 1.0% ophthalmic suspension for treatment of inflammation following phacoemulsification and posterior chamber lens implantation. Methods. One hundred and sixteen patients (diclofenac 57, prednisolone 59) with visually disabling cataract were enrolled in this prospective, randomised, double-masked, parallel group study in two centres. Post-operative patient assessments at day 1, 5–8 and 12–16 included visual acuity, slit-lamp examination, applanation tonometry and subjective evaluation of local tolerance. Results. There was no statistically significant difference between the diclofenac and prednisolone groups in the sum of the grades of anterior chamber flare and cells or the degree of conjunctival hyperaemia at any study visit. The overall assessment of local tolerance was similar for both the study medications. There were two (3.4%) possibly drug-related adverse events in the prednisolone group but neither was severe. Conclusions. Diclofenac sodium 0.01% ophthalmic solution was as effective, safe and well tolerated overall as prednisolone acetate 1.0% ophthalmic suspension.

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