scholarly journals In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery

2016 ◽  
pp. 665
Author(s):  
Diana Urbaneja ◽  
Antonio Morilla ◽  
Elisa Jiménez ◽  
Judith Montemayor ◽  
Nuria Marcobal ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Filtering Surgery ◽  
Materials Used

Morphometric Study of Wound Healing in a Model of Filtering Surgery with Mitomycin-C

1995 ◽  
Vol 5 (3) ◽  
pp. 168-171 ◽  
Author(s):  
L. E. Pablo ◽  
T. Ramírez ◽  
R. Álvarez ◽  
I. González ◽  
J. M. Larrosa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mitomycin C ◽  
In Vitro Models ◽  
Wilcoxon Test ◽  
Morphometric Study ◽  
Filtering Surgery ◽  
Balance Salt ◽  
Pigmented Rabbits

Background Failure of filtering surgery may be related to excessive wound healing in the surgical area. This effect diminishes with the use of antimetabolic agents. Mitomycin-C (MMC) has proved to be the most effective drug to reduce myofibroblastic proliferation in experimental in vivo and in vitro models. To our knowledge, the objective changes induced by mitomycin-C in the size of wound healing areas have not been investigated. Methods: Filtering surgery was performed on both eyes of 40 pigmented rabbits. Preoperatively one of the eyes received MMC (0.5 mg/ml), and the fellow eye received balance salt solution as placebo. Animals were killed on days 6, 15, 30 and 58. Microscopic healing areas were measured by digital procedures. The areas of target and fellow control eyes were compared by the Wilcoxon test. Results This study showed significant differences (p<0.05) between treated and untreated groups, the healing are a gradually becoming smaller. Conclusions Objective methods to quantify the microscopic effects of MMC can be useful to improve our knowledge about the action on this antimetabolite and to enable us to adjust more accurately the timing and dosage when applying the drug in glaucoma filtering surgery.

scholarly journals The effect of platelet-rich fibrin on normal dermal fibroblast proliferation after mitomycin-c treatment: An in vitro study

2021 ◽  
Vol 62 ◽  
pp. 473-476
Author(s):  
Ishandono Dachlan ◽  
Hendy Satrya Kurniawan ◽  
Aditya Wicaksana ◽  
Aditya Rifqi Fauzi ◽  
Firdian Makrufardi ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Dermal Fibroblast ◽  
In Vitro Study ◽  
Vitro Study ◽  
Fibroblast Proliferation ◽  
Platelet Rich Fibrin

scholarly journals Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew N. Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

AbstractCurrent materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

5-FU loaded pHEMA drainage implants for glaucoma-filtering surgery: device design and in vitro release kinetics

Biomaterials ◽  
1996 ◽  
Vol 17 (9) ◽  
pp. 941-949 ◽  
Author(s):  
Meltem Gökce ◽  
R.Fikret Akata ◽  
Menemşe Kiremitçi-Gümüşderelioǧlu
Keyword(s):  
Release Kinetics ◽  
In Vitro Release ◽  
Filtering Surgery ◽  
Device Design ◽  
Vitro Release

Change in outflow pathway of porcine eyes in vitro by nonpenetrating filtering surgery

2010 ◽  
Vol 45 (6) ◽  
pp. 632-636 ◽  
Author(s):  
Wen Xu ◽  
Ke Yao ◽  
Wei Wu ◽  
Zhaochun Li ◽  
Panpan Ye
Keyword(s):  
Filtering Surgery ◽  
Outflow Pathway ◽  
Porcine Eyes

Studies on the in vitro interaction of mitomycin C, nitrofurantoin and paraquat with pulmonary microsomes

1982 ◽  
Vol 31 (5) ◽  
pp. 805-814 ◽  
Author(s):  
Michael A. Trush ◽  
Edward G. Mimnaugh ◽  
Erika Ginsburg ◽  
Theodore E. Gram
Keyword(s):  
Mitomycin C ◽  
In Vitro Interaction

The Aesthetic Effect of All-Ceramic Pressed Crowns According to the Thickness and Color of the Materials Used - An In Vitro Study

2013 ◽  
Vol 587 ◽  
pp. 349-355
Author(s):  
Sergiu Drafta ◽  
Adelina Popescu ◽  
Vlad Naicu
Keyword(s):  
Human Eye ◽  
Color Parameters ◽  
Varying Thickness ◽  
Dental Abutment ◽  
All Ceramic ◽  
Materials Used ◽  
The Aesthetic ◽  
Ceramic Restorations ◽  
Final Color

The final color of all-ceramic restorations may be influenced by the varying thickness of the dental abutment. Eighty A2 color (MO and LT) ceramic discs and eighty A3.5 color and four different thicknesses composite discs of were produced. The measurements were performed using the Vita Easyshade spectrophotometer. The results were statistically analyzed. Conclusion: There are no significant differences (perceived by the human eye) of the color parameters in the CIE L*a*b* system when comparing different combinations.

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