scholarly journals Mediation analysis in genome-wide association studies: current perspectives

2015 ◽  
pp. 1
Author(s):  
Sharon Lutz ◽  
John Hokanson
Keyword(s):  
Mediation Analysis ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association

2021 ◽  
Vol 18 (19) ◽  
pp. 10484
Author(s):  
Ting-Hao Chen ◽  
Chen-Cheng Yang ◽  
Kuei-Hau Luo ◽  
Chia-Yen Dai ◽  
Yao-Chung Chuang ◽  
...  
Keyword(s):  
Renal Function ◽  
Mediation Analysis ◽  
Association Studies ◽  
Dipeptidyl Peptidase ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Mediation Effects ◽  
Genome Wide ◽  
Estimated Glomerular Filtration Rates

Aluminum (Al) toxicity is related to renal failure and the failure of other systems. Although there were some genome-wide association studies (GWAS) in Australia and England, there were no GWAS about Han Chinese to our knowledge. Thus, this research focused on using whole genomic genotypes from the Taiwan Biobank for exploring the association between Al concentrations in plasma and renal function. Participants, who underwent questionnaire interviews, biomarkers, and genotyping, were from the Taiwan Biobank database. Then, we measured their plasma Al concentrations with ICP-MS in the laboratory at Kaohsiung Medical University. We used this data to link genome-wide association (GWA) tests while looking for candidate genes and associated plasma Al concentration to renal function. Furthermore, we examined the path relationship between Single Nucleotide Polymorphisms (SNPs), Al concentrations, and estimated glomerular filtration rates (eGFR) through the mediation analysis with 3000 replication bootstraps. Following the principles of GWAS, we focused on three SNPs within the dipeptidyl peptidase-like protein 6 (DPP6) gene in chromosome 7, rs10224371, rs2316242, and rs10268004, respectively. The results of the mediation analysis showed that all of the selected SNPs have indirectly affected eGFR through a mediation of Al concentrations. Our analysis revealed the association between DPP6 SNPs, plasma Al concentrations, and eGFR. However, further longitudinal studies and research on mechanism are in need. Our analysis was still be the first study that explored the association between the DPP6, SNPs, and Al in plasma affecting eGFR.

scholarly journals iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis

2015 ◽  
Vol 39 (5) ◽  
pp. 347-356 ◽  
Author(s):  
Yen-Tsung Huang ◽  
Liming Liang ◽  
Miriam F. Moffatt ◽  
William O. C. M. Cookson ◽  
Xihong Lin
Keyword(s):  
Mediation Analysis ◽  
Disease Susceptibility ◽  
Association Studies ◽  
Genomic Data ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide
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