scholarly journals Dietary Tryptophan and the Risk of Metabolic Syndrome: Total Effect and Mediation Effect of Sleep Duration

2021 ◽  
Vol Volume 13 ◽  
pp. 2141-2151
Author(s):  
Weiqi Wang ◽  
Lin Liu ◽  
Zhen Tian ◽  
Tianshu Han ◽  
Changhao Sun ◽  
...  
2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S194-S194
Author(s):  
Kexin Yu ◽  
Kexin Yu ◽  
Shinyi Wu ◽  
Iris Chi

Abstract Internet is increasingly popular among older adults and have changed interpersonal interactions. However, it remains controversial whether older people are more or less lonely with internet use. This paper tests the longitudinal association of internet use and loneliness among older people. One pathway that explains the association, the mediation effect of social contact, was examined. Data from the 2006, 2010 and 2014 waves of Health and Retirement Study was used. Hierarchical liner modeling results showed internet use was related to decreased loneliness over 12-year period of time (b=-0.044, p<.001). Internet use was associated with more social contact with family and friends overtime (b=0.261, p<.001), social contact was related to less perceived loneliness longitudinally (b=0.097, p<.001). The total effect of internet use on loneliness is -0.054 and the mediated effect is -0.025. The findings imply that online activities can be effective for reducing loneliness for older people through increased social contact.


2019 ◽  
Author(s):  
Anjelica Simsek ◽  
Cahit Nuri ◽  
Cemaliye Direktor ◽  
Ahmet Arnavut

<p>At this study, meditation effect of aggression was analyzed using Baron and Kenny’s mediation analysis method. Baron and Kenny (1986) indicates that to analyze the effect of mediator variable 3 criteria have to be actualized:</p> <p>1. Independent variable have a significant effect on a mediator variable (way a)</p> <p>2. Mediator variable have a significant effect on a dependent variable (way b)</p> <p>3. Independent variable have a significant effect on a dependent variable (way c)</p> <p>PROCESS program were used the meditational effect, it is an extra macro that is downloading to the Daniel and Hayes’s (2016) SPSS program. In this program mediation effect could be evaluated as; total effect, direct effect and indirect effect scores of mediation variable effect on dependent variable (Preacher & Hayes, 2008).</p>


Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Fan He ◽  
Edward O Bixler ◽  
Jiangang Liao ◽  
Arthur Berg ◽  
Yuka Imamura Kawasawa ◽  
...  

Introduction: Although self-reported sleep duration has been associated with obesity, study of the association between objectively-measured habitual sleep pattern and the more metabolically relevant abdominal obesity, and the mediation factors for such an association, is limited. Hypothesis: We assessed the hypothesis that objectively-measured variability, mediated by excessive energy intake, is associated with abdominal obesity in adolescents. Methods: We used data from 421 adolescents in the Penn State Child Cohort follow-up examination. Actigraphy was used for 7 consecutive nights to calculate each participant’s mean sleep duration as habitual sleep duration (HSD) and the standard deviation of the mean as habitual sleep variability (HSV). Abdominal obesity was assessed by dual-energy x-ray absorptiometry as Android/Gynoid Fat Ratio and visceral fat area . Youth/Adolescents Food Frequency Questionnaire was used to obtain daily caloric, fat, carbohydrate, and protein intakes one year prior to the study. The R-based Mediation Effect Models were used to assess the association between sleep pattern and abdominal obesity, and quantitatively estimate the mediation effects of caloric intake and of other factors not analyzed in this report. Results: As shown in the table, after controlling for major confounders and BMI percentile, HSV was significantly and consistently associated with both abdominal obesity measures. The Mediation analysis consistently indicated a significant mediation effect of caloric intake, especially carbohydrate intake. For example, 20% of the association between HSV and visceral fat could be attributed to carbohydrate intake, while 80% by other factors not analyzed. HSD was not associated with abdominal obesity. Conclusions: Higher HSV, not HSD, is associated with abdominal obesity, which can be partially explained by increased caloric intake, especially from carbohydrate, in adolescents. More studies are needed to identify other mediation factors in the association.


2020 ◽  
Author(s):  
Hui Zhao ◽  
Miao-miao Jiang ◽  
Sang Hu ◽  
Chang Su ◽  
Li Zhang ◽  
...  

Abstract Background: The relationship between diabetes and myocardial infarction has always been the focus of research, but it is not clear whether the DM-MI association is direct or mediated by other factors. Our hypothesis is that part of the risk of MI in DM patients may be mediated by CRP and AST. We examined this hypothesis in the mediation analysis and tried to assess the extent to which CRP and AST could explain the MI risk caused by DM.Methods: This case-control study was conducted on 130 patients with MI and 130 patients with no-MI. We compared the relevant biochemical indicators of MI and no-MI patients, and applied mediation analysis to test the association of CRP and AST with DM-MI Potential adjustment effect.Results: The study found that individuals who suffered MI were more likely to have DM as compared with Non-MI (OR = 2.117, 95%CI = 1.130-4.195, P = 0.020), and CRP and AST are positively correlated with the occurrence of MI, For every unit increase in CRP and AST levels, the risk level of MI Significantly increased by 1%, 3.1% respectively. The direct effect of DM and MI is 0.847, the mediating effect of CRP is 7.69% of the total effect, and the mediating effect of AST is 52.79% of the total effect. The mediation effect of the CRP-AST path is 0.386, accounting for 12.36% of the total effect. In the mediation model we verified, CRP and AST play a part of the mediation effect between DM with MI, and the total mediation effect accounts for 72.84%.Conclusions: CRP and AST play an important role in the risk of DM-induced MI. This provides evidence for the mechanism and is of great significance for the exploration of therapeutic targets.


Medicine ◽  
2020 ◽  
Vol 99 (2) ◽  
pp. e18753 ◽  
Author(s):  
Lei Fan ◽  
Zilong Hao ◽  
Li Gao ◽  
Minjie Qi ◽  
Shixian Feng ◽  
...  

Diabetes Care ◽  
2011 ◽  
Vol 34 (10) ◽  
pp. 2317-2319 ◽  
Author(s):  
T. Arora ◽  
C. Q. Jiang ◽  
G. N. Thomas ◽  
K.-b. H. Lam ◽  
W. S. Zhang ◽  
...  

Work ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Erin C. McCanlies ◽  
James E. Slaven ◽  
Lindsay M. Smith ◽  
Michael E. Andrew ◽  
Luenda E. Charles ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document