scholarly journals Sleep and Methylation of Estrogen Receptor Genes, ESR1 and GPER, in Healthy Middle-Aged and Older Women: Findings from the Women 40+ Healthy Aging Study

2020 ◽  
Vol Volume 12 ◽  
pp. 525-536
Author(s):  
Elena S Gardini ◽  
Serena Fiacco ◽  
Laura Mernone ◽  
Ulrike Ehlert
Keyword(s):  
Estrogen Receptor ◽  
Older Women ◽  
Healthy Aging ◽  
Middle Aged ◽  
Aging Study

scholarly journals Purpose in life is a robust protective factor of reported cognitive decline among late middle-aged adults: The Emory Healthy Aging Study

2020 ◽  
Vol 263 ◽  
pp. 310-317 ◽  
Author(s):  
Aliza P. Wingo ◽  
Thomas S. Wingo ◽  
Wen Fan ◽  
Sharon Bergquist ◽  
Alvaro Alonso ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Healthy Aging ◽  
Protective Factor ◽  
Purpose In Life ◽  
Middle Aged ◽  
Aging Study ◽  
Middle Aged Adults

scholarly journals Differential ESR1 Promoter Methylation in the Peripheral Blood—Findings from the Women 40+ Healthy Aging Study

2020 ◽  
Vol 21 (10) ◽  
pp. 3654 ◽  
Author(s):  
Elena S. Gardini ◽  
Gary G. Chen ◽  
Serena Fiacco ◽  
Laura Mernone ◽  
Jasmine Willi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Older Women ◽  
Healthy Aging ◽  
Regulatory Region ◽  
Dried Blood Spots ◽  
Estrogen Receptor Α ◽  
Direct Role ◽  
Healthy Women ◽  
Distal Regulatory Region ◽  
Aging Study

Background Estrogen receptor α (ERα) contributes to maintaining biological processes preserving health during aging. DNA methylation changes of ERα gene (ESR1) were established as playing a direct role in the regulation of ERα levels. In this study, we hypothesized decreased DNA methylation of ESR1 associated with postmenopause, lower estradiol (E2) levels, and increased age among healthy middle-aged and older women. Methods We assessed DNA methylation of ESR1 promoter region from dried blood spots (DBSs) and E2 from saliva samples in 130 healthy women aged 40–73 years. Results We found that postmenopause and lower E2 levels were associated with lower DNA methylation of a distal regulatory region, but not with DNA methylation of proximal promoters. Conclusion Our results indicate that decreased methylation of ESR1 cytosine-phosphate-guanine island (CpGI) shore may be associated with conditions of lower E2 in older healthy women.

scholarly journals Connection to the Gay Community and Self-Appraisals Among Older Men Who Have Sex With Men

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 824-824
Author(s):  
Mark Brennan-Ing ◽  
Michael Plankey ◽  
Sabina Haberlen ◽  
Steven Meanley ◽  
Andre Brown ◽  
...  
Keyword(s):  
Body Dissatisfaction ◽  
Psychological Health ◽  
Structural Equation ◽  
Healthy Aging ◽  
Developmental Regulation ◽  
Equation Modeling ◽  
Gay Community ◽  
Aging Study ◽  
Regulation Strategies ◽  
Sex With Men

Abstract Men who have sex with men (MSM) report greater body dissatisfaction compared with heterosexual men, which increases with age. This may result from internalized gay community values regarding ideal physiques and youth. Using structural equation modeling, we examined these relationships among 1,118 MSM men age 40 and older from the Healthy Aging Study (M age=59.9 years/50.1% HIV+/69.8% non-Hispanic White). We hypothesized gay community attachment would be related to self-appraisals (body dissatisfaction/internalized ageism), and that this relationship would be mediated by developmental regulation strategies (physical activity/exercise intentions). The model fit the data well (RMSEA = .048, 90% CI 0.017-0.079). Contrary to our hypothesis, connection to the gay community was related to positive self-appraisals (-.40, p<.001), with significant indirect effects via regulation strategies (-.12, p<.002). Thus, gay community connections are related to positive self-appraisals in older GB men and enhance strategies supporting physical and psychological health. Implications for practice will be discussed.

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