scholarly journals Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study

2020 ◽  
Vol Volume 12 ◽  
pp. 333-345
Author(s):  
Wanqing Liu ◽  
Chuanlong Cao ◽  
Bing Hu ◽  
Danyang Li ◽  
Yumei Sun ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Structural Mri ◽  
Adult Patients ◽  
Severe Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Mri Study ◽  
Hypopnea Syndrome

MAXILLOMANDIBULAR ADVANCEMENT IN THE TREATMENT OF SEVERE OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME: A CASE REPORT

2020 ◽  
Vol 130 (3) ◽  
pp. e167
Author(s):  
MARK JON SANTANA SABEY ◽  
FÁBIO RICARDO LOUREIRO SATO ◽  
DANILO DE PAULA RIBEIRO BORGES ◽  
MARCOS ANTÔNIO LIMA DOS SANTOS ◽  
LUCAS CELESTINO GUERZET AYRES ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Case Report ◽  
Sleep Apnea ◽  
Severe Obstructive Sleep Apnea ◽  
Maxillomandibular Advancement ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

Two cases of severe obstructive sleep apnea-hypopnea syndrome in which a mandibular advancing positioner was markedly effective

2003 ◽  
Vol 1 (2) ◽  
pp. 127-129 ◽  
Author(s):  
Shizumi GOTO ◽  
Yukiko SUZUKI ◽  
Noriko CHIYOJIMA ◽  
Ayako MUTA ◽  
Hideo OGINO ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Severe Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome

scholarly journals Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Li Zhou ◽  
Ruoyun Ouyang ◽  
Hong Luo ◽  
Yating Peng ◽  
Ping Chen ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Signaling Pathway ◽  
Neurocognitive Impairment ◽  
Apnea Hypopnea Index ◽  
Heme Oxygenase 1 ◽  
Severe Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome ◽  
Nrf2 Protein

The present study investigated the nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response element (ARE) signaling pathway in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome (OSAHS). Their correlation with neurocognitive impairment metrics was investigated to explore potential pathogenesis in OSAHS. Forty-eight patients with OSAHS and 28 controls underwent testing with the Epworth Sleep Scale (ESS), MATRICS Consensus Cognitive Battery (MCCB), Stroop Color and Word Test, polysomnography (PSG), and measurements of the concentration of plasma superoxide dismutase (SOD) and thioredoxin (Trx). Further, 20 pairs of matched patients with OSAHS and controls were selected for measurement of the expression (protein and mRNA) of Nrf2 and of its downstream antioxidase, heme oxygenase-1 (HO-1), in peripheral mononuclear cells (PBMCs). Finally, correlations between neurocognitive impairment and the above metrics were analyzed. Expression of Nrf2 and HO-1 mRNA and protein in the PBMCs, as well as plasma SOD and Trx levels, were significantly reduced in patients with OSAHS. After adjusting for education, sex, age, and smoking index, the expression of Nrf2-ARE signaling pathway proteins (or mRNA) was closely correlated with sleep respiratory parameters. An inverse relationship was demonstrated between the expression of nuclear Nrf2 in PBMCs, concentration of plasma SOD and Trx, and apnea-hypopnea index (AHI) in patients with OSAHS. Trx, nuclear Nrf2 protein, and HO-1 protein were also negatively correlated with the percent of time that SaO2 was less than 90% (TSat90). Total Nrf2 protein level was positively correlated with AHI and TSat90 and negatively correlated with minimum SaO2 (LSaO2), while nuclear Nrf2 protein and HO-1 protein were positively correlated with LSaO2. Moreover, significant positive correlations were found between maze scores and expression of nuclear Nrf2 protein, HO-1 protein, and SOD and Trx levels. Furthermore, inverse relationships between total Nrf2 protein in PBMCs and HVLT-R and maze scores were found. Multiple linear regression showed plasma Trx concentration as a potential predictor of maze and BVMT-R scores. In conclusion, the expression of Nrf2-ARE molecules and related antioxidases is significantly decreased in patients with OSAHS and is correlated with neurocognitive dysfunction. The Nrf2-ARE signaling pathway may play a crucial role in neurocognitive impairment in patients with moderate to severe OSAHS. Further studies are needed to explore the exact mechanisms and potential treatment interventions.

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