scholarly journals Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [14C]-doxorubicin [Corrigendum]

2016 ◽  
Vol Volume 9 ◽  
pp. 47-48 ◽  
Author(s):  
Mas Jaffri Masarudin ◽  
Suzanne Cutts ◽  
Benny Evison ◽  
Don Phillips ◽  
Paul Pigram ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Anticancer Drug ◽  
Chitosan Nanoparticles ◽  
Cellular Accumulation ◽  
Drug Delivery Application ◽  
Anticancer Drug Delivery ◽  
The Stability

Chitosan nanoparticles for lipophilic anticancer drug delivery: Development, characterization and in vitro studies on HT29 cancer cells

2016 ◽  
Vol 145 ◽  
pp. 362-372 ◽  
Author(s):  
Angela Abruzzo ◽  
Giampaolo Zuccheri ◽  
Federica Belluti ◽  
Simona Provenzano ◽  
Laura Verardi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Chitosan Nanoparticles ◽  
In Vitro Studies ◽  
Anticancer Drug Delivery

ARGININE- AND ACRYLONITRILE-MODIFIED CHITOSAN NANOPARTICLES FOR ANTICANCER DRUG DELIVERY

NANO ◽  
2014 ◽  
Vol 09 (07) ◽  
pp. 1450075 ◽  
Author(s):  
LIANCHENG YIN ◽  
TING SU ◽  
JING CHANG ◽  
RONG LIU ◽  
BIN HE ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Laser Scanning ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Anticancer Drug Delivery ◽  
Modified Chitosan

Chitosan (CS) is an excellent natural biodegradable and biocompatible polymer for biomedical applications, however, its poor solubility in water or organic solvents limits its applications in drug delivery. In order to resolve this problem, chitosan was modified with acrylonitrile (AN) and arginine (Arg), the modified chitosan (AN–CS–Arg) was characterized by 1 H NMR and Fourier transform infrared (FTIR). The AN–CS–Arg was self-assembled into nanoparticles to encapsulate anticancer drug doxorubicin (DOX). The size and morphology of the blank and drug-loaded AN–CS–Arg (AN–CS–Arg/DOX) nanoparticles were measured by dynamic light scattering (DLS), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The mean size of both blank and AN–CS–Arg/DOX nanoparticles were around 50 nm and 170 nm, respectively. The drug-loading content was about 12%. The release profile of AN–CS–Arg/DOX nanoparticles was investigated in vitro, 80% encapsulated DOX could be released within 80 h. The AN–CS–Arg nanoparticles were nontoxic to both NIH 3T3 fibroblasts and HepG2 cancer cells. The cellular uptake of the AN–CS–Arg nanoparticles was trafficked via Confocal Laser Scanning Microscopy and Flow Cytometry, both results showed that the AN–CS–Arg nanoparticles could be internalized in HepG2 cells efficiently. The IC50 of AN–CS–Arg/DOX nanoparticles to HepG2 cancer cells was 10.0 μg/mL. The AN–CS–Arg nanoparticles are potential carriers for anticancer drug delivery.

Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery

Biomaterials ◽  
2015 ◽  
Vol 52 ◽  
pp. 240-250 ◽  
Author(s):  
Zhipeng Chen ◽  
Liujie Zhang ◽  
Yang Song ◽  
Jiayu He ◽  
Li Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Chitosan Nanoparticles ◽  
Anticancer Drug Delivery
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