scholarly journals Reduced Synaptic Plasticity Contributes to Resistance Against Constant-Stimulus Electroconvulsive Treatment in a Rat Model of Stress-Induced Depression

2021 ◽  
Vol Volume 17 ◽  
pp. 1433-1442
Author(s):  
Bin Wu ◽  
Yuanyuan Guo ◽  
Jie Deng ◽  
Qibin Chen ◽  
Su Min
Keyword(s):  
Synaptic Plasticity ◽  
Rat Model ◽  
Constant Stimulus ◽  
Electroconvulsive Treatment

P.1.27 Functional and molecular correlates of synaptic plasticity in a gene–environment combination rat model of depression

2007 ◽  
Vol 17 ◽  
pp. S24
Author(s):  
L. Musazzi ◽  
V.S. Barbiero ◽  
A. Mallei ◽  
A. Mathè ◽  
A. El Khoury ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Rat Model ◽  
Gene Environment

scholarly journals Embelin Improves the Spatial Memory and Hippocampal Long-Term Potentiation in a Rat Model of Chronic Cerebral Hypoperfusion

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Saatheeyavaane Bhuvanendran ◽  
Siti Najmi Syuhadaa Bakar ◽  
Yatinesh Kumari ◽  
Iekhsan Othman ◽  
Mohd. Farooq Shaikh ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spatial Memory ◽  
Rat Model ◽  
Long Term Potentiation ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Mrna Levels ◽  
Post Surgery ◽  
Term Potentiation

Abstract Alzheimer’s disease (AD) is the second most occurring neurological disorder after stroke and is associated with cerebral hypoperfusion, possibly contributing to cognitive impairment. In the present study, neuroprotective and anti-AD effects of embelin were evaluated in chronic cerebral hypoperfusion (CCH) rat model using permanent bilateral common carotid artery occlusion (BCCAO) method. Rats were administered with embelin at doses of 0.3, 0.6 or 1.2 mg/kg (i.p) on day 14 post-surgery and tested in Morris water maze (MWM) followed by electrophysiological recordings to access cognitive abilities and synaptic plasticity. The hippocampal brain regions were extracted for gene expression and neurotransmitters analysis. Treatment with embelin at the doses of 0.3 and 0.6 mg/kg significantly reversed the spatial memory impairment induced by CCH in rats. Embelin treatment has significantly protected synaptic plasticity impairment as assessed by hippocampal long-term potentiation (LTP) test. The mechanism of this study demonstrated that embelin treatment alleviated the decreased expression of BDNF, CREB1, APP, Mapt, SOD1 and NFκB mRNA levels caused by CCH rats. Furthermore, treatment with embelin demonstrated neuromodulatory activity by its ability to restore hippocampal neurotransmitters. Overall these data suggest that embelin improve memory and synaptic plasticity impairment in CCH rats and can be a potential drug candidate for neurodegenerative disease-related cognitive disorders.

The Effect of Electroconvulsive Treatment on Thermal Hyperalgesia and Mechanical Allodynia in a Rat Model of Peripheral Neuropathy

1998 ◽  
Vol 86 (3) ◽  
pp. 584-587 ◽  
Author(s):  
Masahiko Shibata ◽  
Satoshi Wakisaka ◽  
Takaya Inoue ◽  
Tadao Shimizu ◽  
Ikuto Yoshiya
Keyword(s):  
Peripheral Neuropathy ◽  
Rat Model ◽  
Mechanical Allodynia ◽  
Thermal Hyperalgesia ◽  
Electroconvulsive Treatment

scholarly journals Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

2020 ◽  
Vol 12 ◽  
Author(s):  
Valeria Calabrese ◽  
Anna Di Maio ◽  
Gioia Marino ◽  
Antonella Cardinale ◽  
Giuseppina Natale ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Rat Model ◽  
Mtorc1 Signaling

Neurotoxic effects of high-dose piperine on hippocampal synaptic transmission and synaptic plasticity in a rat model of memory impairment

2020 ◽  
Vol 79 ◽  
pp. 200-208 ◽  
Author(s):  
Masoomeh Nazifi ◽  
Manoochehr Ashrafpoor ◽  
Shahrbanoo Oryan ◽  
Delaram Eslimi Esfahani ◽  
Ali Akbar Moghadamnia
Keyword(s):  
Synaptic Plasticity ◽  
Synaptic Transmission ◽  
Rat Model ◽  
Memory Impairment ◽  
High Dose ◽  
Neurotoxic Effects

scholarly journals NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Xue-Ying Wang ◽  
Hui-Ru Zhou ◽  
Sha Wang ◽  
Chao-Yang Liu ◽  
Guang-Cheng Qin ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Chronic Migraine ◽  
Rat Model ◽  
Central Sensitization

scholarly journals Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135700 ◽  
Author(s):  
D. Bhattacharya ◽  
E. P. Dunaway ◽  
S. Bhattacharya ◽  
J. Bloemer ◽  
M. Buabeid ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Rat Model
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