scholarly journals Correlations Between Working Memory Impairment and Neurometabolites of the Prefrontal Cortex in Drug-Naive Obsessive-Compulsive Disorder

2021 ◽  
Vol Volume 17 ◽  
pp. 2647-2657
Author(s):  
Jihui Yue ◽  
Shuming Zhong ◽  
Aimin Luo ◽  
Shunkai Lai ◽  
Tingting He ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Obsessive Compulsive Disorder ◽  
Memory Impairment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Drug Naïve

Do organizational strategies mediate nonverbal memory impairment in drug-naïve patients with obsessive-compulsive disorder?

2010 ◽  
Vol 24 (4) ◽  
pp. 527-533 ◽  
Author(s):  
Na Young Shin ◽  
Do-Hyung Kang ◽  
Jung-Seok Choi ◽  
Myung Hun Jung ◽  
Joon Hwan Jang ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Memory Impairment ◽  
Organizational Strategies ◽  
Obsessive Compulsive ◽  
Nonverbal Memory ◽  
Compulsive Disorder ◽  
Drug Naïve

scholarly journals Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder

2020 ◽  
Author(s):  
Qianqian Li ◽  
Jun Yan ◽  
Jinmin Liao ◽  
Xiao Zhang ◽  
Lijun Liu ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Obsessive Compulsive Disorder ◽  
Medial Prefrontal Cortex ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Right

Abstract Stress might exaggerate the compulsion and impair the working memory of patients with obsessive-compulsive disorder (OCD). This study evaluated the effect of stress on the cognitive neural processing of working memory in OCD and its clinical significance using a “number calculation working memory” task. Thirty-eight patients and 55 gender- and education-matched healthy controls were examined. Stress impaired the performance of the manipulation task in patients. Healthy controls showed less engagement of the medial prefrontal cortex and striatum during the task under stress versus less stress, which was absent in the patients with OCD. The diagnosis × stress interaction effect was significant in the right fusiform, supplementary motor area, precentral cortex and caudate. The failure of suppression of the medial prefrontal cortex and striatum and stress-related hyperactivation in the right fusiform, supplementary motor area, precentral cortex, and caudate might be an OCD-related psychopathological and neural response to stress.

Forgetting What You Have Checked: A Link Between Working Memory Impairment and Checking Behaviors in Obsessive-Compulsive Disorder

2011 ◽  
Vol 28 (2) ◽  
pp. 87-93 ◽  
Author(s):  
N. Jaafari ◽  
M. Frasca ◽  
F. Rigalleau ◽  
F. Rachid ◽  
R. Gil ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Memory Impairment ◽  
Memory Span ◽  
Obsessive Compulsive ◽  
Comparison Task ◽  
Compulsive Disorder ◽  
Non Invasive ◽  
Checking Behavior ◽  
Compulsive Checking

AbstractBackgroundCompulsive checking behaviors are common in obsessive-compulsive disorder (OCD). Several authors have suggested that these checking rituals could be related to memory deficits. Our aim was to test whether patients with OCD show working memory impairment in relation to their checking behavior.MethodsWe evaluated the verbal and visuospatial components of patients’ and controls’ working memory using the reading span and backward location span tests. Checking behaviors were measured by recording participants’ eye movements during an image comparison task using a non-invasive, infra-red TOBII 1750 eyetracker. Participants were seated, head-free, in a natural position in front of the eyetracker screen where the images were displayed.ResultsPatients with OCD made more gaze moves to compare images than controls. Both patients’ working memory spans were reduced, and the patients’ deficit in the comparison task was negatively related to their working memory spans.ConclusionsThis work demonstrates that checking behavior in OCD is linked to a general reduction of the patients’ verbal and visuospatial working memory span.

Clinical correlates of caudate volume in drug-naïve adult patients with obsessive–compulsive disorder

2013 ◽  
Vol 212 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Janardhanan C. Narayanaswamy ◽  
Dania A. Jose ◽  
Sunil V. Kalmady ◽  
Ganesan Venkatasubramanian ◽  
Y.C. Janardhana Reddy
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Adult Patients ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Drug Naïve

scholarly journals Neural correlates of working memory deficits and associations to response inhibition in obsessive compulsive disorder

2018 ◽  
Vol 17 ◽  
pp. 426-434 ◽  
Author(s):  
Stephan Heinzel ◽  
Christian Kaufmann ◽  
Rosa Grützmann ◽  
Robert Hummel ◽  
Julia Klawohn ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Memory Deficits ◽  
Neural Correlates ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder

1999 ◽  
Vol 45 (7) ◽  
pp. 905-916 ◽  
Author(s):  
Cary R Savage ◽  
Lee Baer ◽  
Nancy J Keuthen ◽  
Halle D Brown ◽  
Scott L Rauch ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Memory Impairment ◽  
Organizational Strategies ◽  
Obsessive Compulsive ◽  
Nonverbal Memory ◽  
Compulsive Disorder

scholarly journals Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior

2019 ◽  
Vol 116 (9) ◽  
pp. 3799-3804 ◽  
Author(s):  
Tingting Sun ◽  
Zihua Song ◽  
Yanghua Tian ◽  
Wenbo Tian ◽  
Chunyan Zhu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Obsessive Compulsive Disorder ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala ◽  
Obsessive Compulsive ◽  
Neuronal Tracing ◽  
Compulsive Disorder ◽  
Glutamatergic Neurons ◽  
Fmri Study ◽  
Checking Behavior

Obsessive-compulsive disorder (OCD) affects ∼1 to 3% of the world’s population. However, the neural mechanisms underlying the excessive checking symptoms in OCD are not fully understood. Using viral neuronal tracing in mice, we found that glutamatergic neurons from the basolateral amygdala (BLAGlu) project onto both medial prefrontal cortex glutamate (mPFCGlu) and GABA (mPFCGABA) neurons that locally innervate mPFCGlu neurons. Next, we developed an OCD checking mouse model with quinpirole-induced repetitive checking behaviors. This model demonstrated decreased glutamatergic mPFC microcircuit activity regulated by enhanced BLAGlu inputs. Optical or chemogenetic manipulations of this maladaptive circuitry restored the behavioral response. These findings were verified in a mouse functional magnetic resonance imaging (fMRI) study, in which the BLA–mPFC functional connectivity was increased in OCD mice. Together, these findings define a unique BLAGlu→mPFCGABA→Glu circuit that controls the checking symptoms of OCD.

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