scholarly journals Protective Effects of Spirulina platensis, Voluntary Exercise and Environmental Interventions Against Adolescent Stress-Induced Anxiety and Depressive-Like Symptoms, Oxidative Stress and Alterations of BDNF and 5HT-3 Receptors of the Prefrontal Cortex in Female Rats

2020 ◽  
Vol Volume 16 ◽  
pp. 1777-1794
Author(s):  
Nasroallah Moradi-Kor ◽  
Masoumeh Dadkhah ◽  
Ali Ghanbari ◽  
Hadi Rashidipour ◽  
Ahmad Reza Bandegi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Spirulina Platensis ◽  
Voluntary Exercise ◽  
Female Rats ◽  
Protective Effects ◽  
Environmental Interventions ◽  
Adolescent Stress

scholarly journals Propolis Protective Effects Against Doxorubicin-Induced Multi-Organ Toxicity via Suppression of Oxidative Stress, Inflammation, Apoptosis, and Histopathological Alterations in Female Albino Rats

2021 ◽  
Vol 12 (2) ◽  
pp. 1762-1777
Keyword(s):  
Oxidative Stress ◽  
Large Scale ◽  
Protective Efficacy ◽  
Biological Activities ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Protective Agent ◽  
Protective Effects ◽  
Treatment Protocols

Doxorubicin (DOX) is effective chemotherapy in several malignancies, but large-scale toxicities limit its clinical usefulness. Propolis has been reported to exhibit a broad spectrum of biological activities. We aim to assess the protective efficacy of propolis against DOX-induced multi-toxicity in female rats. Forty female rats were divided into four groups: control group; Group (P) were administrated oral propolis (100 mg/kg once daily for 28 days); Group (P+DOX) were injected with a single intraperitoneal dose of DOX (20 mg/kg i.p at 24th day after the propolis administration) and group (DOX) were injected with doxorubicin only. Estimation of cardiac, renal and hepatic injury markers, apoptosis and pro-inflammatory cytokines were done using sera. Also, liver and heart tissue samples were collected to determine GSH and MDA as oxidative stress markers. In addition to histopathological and immunohistochemical examination of Cytochrome-C and Connexin43 on lysed myocardium, liver, kidney and lung tissues. Doxorubicin toxicity caused marked deteriorations of measured parameters through the different mechanisms in different body organs. However, pre-treatment with propolis significantly ameliorated these alterations. Thus propolis can ameliorate the DOX-induced experimental multi-toxicity as cardiomyopathy, hepatotoxicity, nephritis and pneumonia. Thus, it could be a promising protective agent in DOX treatment protocols.

scholarly journals Protective Effects of Centella asiatica on Cognitive Deficits Induced by D-gal/AlCl3 via Inhibition of Oxidative Stress and Attenuation of Acetylcholinesterase Level

Toxics ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 19 ◽  
Author(s):  
Samaila Chiroma ◽  
Mohamad Baharuldin ◽  
Che Mat Taib ◽  
Zulkhairi Amom ◽  
Saravanan Jagadeesan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Prefrontal Cortex ◽  
Cognitive Deficits ◽  
Neurodegenerative Disorder ◽  
Centella Asiatica ◽  
Morris Water Maze Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Protective Effects ◽  
Ultrastructural Alteration

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cholinergic dysfunctions and impaired redox homeostasis. The plant Centella asiatica (CA) is renowned for its nutritional benefits and herbal formulas for promoting health, enhancing cognition, and its neuroprotective effects. The present study aims to investigate the protective role of CA on D-gal/AlCl3-induced cognitive deficits in rats. The rats were divided into six groups and administered with donepezil 1 mg/kg/day, CA (200, 400, and 800 mg/kg/day) and D-gal 60 mg/kg/day + AlCl3 200 mg/kg/day for 10 weeks. The ethology of the rats was evaluated by the Morris water maze test. The levels of acetylcholinesterase (AChE), phosphorylated tau (P-tau), malondialdehyde (MDA) and activities of superoxide dismutase (SOD), in the hippocampus and cerebral cortex were estimated by enzyme-linked immunosorbent assay (ELISA). Additionally, the ultrastructure of the prefrontal cortex of the rats’ was observed using transmission electron microscopy (TEM). Rats administered with D-gal/AlCl3 exhibited cognitive deficits, decreased activities of SOD, and marked increase in AChE and MDA levels. Further, prominent alterations in the ultrastructure of the prefrontal cortex were observed. Conversely, co-administration of CA with D-gal/AlCl3 improved cognitive impairment, decreased AChE levels, attenuated the oxidative stress in hippocampus and cerebral cortex, and prevented ultrastructural alteration of neurons in the prefrontal cortex. Irrespective of the dose of CA administered, the protective effects were comparable to donepezil. In conclusion, this study suggests that CA attenuated the cognitive deficits in rats by restoring cholinergic function, attenuating oxidative stress, and preventing the morphological aberrations.

scholarly journals Protective Effect of Hydroethanolic Extracts of Solanum scabrum and Cola verticillata Against Cyclophosphamide Induced Toxicity in Female Rats

2014 ◽  
Vol 3 (3) ◽  
pp. 18 ◽  
Author(s):  
Mbong Angie M-A ◽  
Djiokeng Paka G. ◽  
Ntentie F. R. ◽  
Dimodi H. ◽  
Ngondi J. L. ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intraperitoneal Administration ◽  
Female Rats ◽  
Protective Effects ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Toxicity ◽  
Cyclophosphamide Treatment ◽  
Hydroethanolic Extract ◽  
Antioxidant Mechanisms

<p>The aim of this study was to evaluate the protective effects of hydroethanolic extracts of <em>S.</em> <em>scabrum</em> and <em>C. verticillata</em> against cyclophosphamide induced toxicity. In this light, female albino wistar rats were treated by intraperitoneal administration of 100 mg/kg BW of cyclophosphamide or distilled water every other day for 7 days associated with oral gavage using hydroethanolic extract of <em>C. verticillata</em>/<em>S. scabrum</em> at a dose of 200 or 400 mg/kg BW or not every day for the same 7 days. On the 8th day, blood and organs (liver, heart and kidney) were collected for analyses of toxicity-related and oxidative stress markers. Cyclophosphamide treatment induced significant toxicity as shown by liver enzymes, urea and creatinine levels. The administration of extracts helped reduce the levels of these markers. The antioxidant effect of these extracts also helped or not to ameliorate oxidative stress markers (MDA, NO, hydroperoxides, catalase, thiols, GPx) depending on the extract and on the dose administered. These results suggest that administration of hydroethanolic extracts of <em>S.</em> <em>scabrum</em> and <em>C. verticillata</em> can help prevent or reduce toxicity that is brought about by treatment with cyclophosphamide due to their ability to upregulate antioxidant mechanisms.</p>

scholarly journals Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats

2021 ◽  
Vol 14 ◽  
Author(s):  
María Elena Quintanilla ◽  
Paola Morales ◽  
Fernando Ezquer ◽  
Marcelo Ezquer ◽  
Mario Herrera-Marschitz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Prefrontal Cortex ◽  
Acetylsalicylic Acid ◽  
Female Rats ◽  
Mrna Levels ◽  
Drug Induced ◽  
Nicotine Intake ◽  
Valuable Adjunct ◽  
Oral Nicotine

BackgroundNicotine is the major addictive component of cigarette smoke and the prime culprit of the failure to quit smoking. Common elements perpetuating the use of addictive drugs are (i) cues associated with the setting in which drug was used and (ii) relapse/reinstatement mediated by an increased glutamatergic tone (iii) associated with drug-induced neuroinflammation and oxidative stress.AimsThe present study assessed the effect of the coadministration of the antioxidant N-acetylcysteine (NAC) plus the anti-inflammatory acetylsalicylic acid (ASA) on oral nicotine reinstatement intake following a post-deprivation re-access in female rats that had chronically and voluntarily consumed a nicotine solution orally. The nicotine-induced oxidative stress and neuroinflammation in the hippocampus and its effects on the glutamate transporters GLT-1 and XCT mRNA levels in prefrontal cortex were also analyzed.ResultsThe oral coadministration of NAC (40 mg/kg/day) and ASA (15 mg/kg/day) inhibited by 85% of the oral nicotine reinstatement intake compared to control (vehicle), showing an additive effect of both drugs. Acetylsalicylic acid and N-acetylcysteine normalized hippocampal oxidative stress and blunted the hippocampal neuroinflammation observed upon oral nicotine reinstatement. Nicotine downregulated GLT-1 and xCT gene expression in the prefrontal cortex, an effect reversed by N-acetylcysteine, while acetylsalicylic acid reversed the nicotine-induced downregulation of GLT-1 gene expression. The inhibitory effect of N-acetylcysteine on chronic nicotine intake was blocked by the administration of sulfasalazine, an inhibitor of the xCT transporter.ConclusionNicotine reinstatement, following post-deprivation of chronic oral nicotine intake, downregulates the mRNA levels of GLT-1 and xCT transporters, an effect reversed by the coadministration of N-acetylcysteine and acetylsalicylic acid, leading to a marked inhibition of nicotine intake. The combination of these drugs may constitute a valuable adjunct in the treatment of nicotine-dependent behaviors.

Hepatoprotective Effects of Algerian Crataegus oxyacantha Leaves

2019 ◽  
Vol 10 (1) ◽  
pp. 70-75
Author(s):  
Amira Mecheri ◽  
Wassila Benabderrahmane ◽  
Amel Amrani ◽  
Nassima Boubekri ◽  
Fadila Benayache ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Female Rats ◽  
Protective Effects ◽  
Edible Plant ◽  
Traditional Use ◽  
Butanol Extract ◽  
Hepatic Diseases ◽  
Pharmaceutical Industries ◽  
Hepatoprotective Effects

Background: Hawthorn (C. oxyacantha), a common edible plant, is widely used for the preparation of a different foodstuff and is also used in traditional medicine to treat heart problems and gastrointestinal ailments. Recently, a few patents of Crataegus preparation for protective effects (prevention of cardiovascular and hepatic diseases) have been developed. </P><P> Objective: The current study aimed to explore the antioxidant and hepatoprotective effects of nbutanol extract of Crataegus oxyacantha leaves in acute liver damage induced by Doxorubicin (DOX). </P><P> Methods: Crataegus oxyacantha (100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg body weight) were administered orally to female rats for 10 days, in the presence or absence of hepatotoxicity induced by a single intraperitoneal (i.p.) injection of DOX (15 mg/kg on the 8th day). On day 11, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used for determination of oxidative stress parameters that include Malondialdehyde (MDA), Glutathione (GSH) level and Glutathione Peroxidase (GPx) activity. </P><P> Results: Treatment with n-butanol extract of C. oxyacantha leaves significantly improved the altered liver enzyme activities and oxidative stress markers. The histopathological observations confirm the results of biochemical parameters. </P><P> Conclusion: The obtained results support the traditional use of C. oxyacantha to cure gastrointestinal ailments and highlighted its possible use in the food and pharmaceutical industries as a source of natural antioxidant.

Oxidative stress in prefrontal cortex of rat exposed to MK-801 and protective effects of CAPE

2007 ◽  
Vol 31 (4) ◽  
pp. 832-838 ◽  
Author(s):  
Birsen Ozyurt ◽  
Huseyin Ozyurt ◽  
Nusret Akpolat ◽  
Hasan Erdogan ◽  
Mustafa Sarsilmaz
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Protective Effects ◽  
Mk 801

scholarly journals Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 385 ◽  
Author(s):  
Sung Min Nam ◽  
Sun-Hye Choi ◽  
Hee-Jung Cho ◽  
Jin Seok Seo ◽  
Minsuk Choi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Purkinje Cells ◽  
Female Rats ◽  
Protective Effects ◽  
Brain Functions ◽  
Pregnancy And Lactation ◽  
Pb Exposure ◽  
Gaba Transporter 1 ◽  
Developing Cerebellum ◽  
Potential Use

Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, improves brain functions and protects neurons from oxidative stress. However, little is known about the effects of gintonin against Pb-induced brain maldevelopment. We investigated the protective effects of gintonin on the developing cerebellum after prenatal and postnatal Pb exposure. Pregnant female rats were randomly divided into three groups: control, Pb (0.3% Pb acetate in drinking water), and Pb plus gintonin (100 mg/kg, p.o.). Blood Pb was increased in dams and pups; gintonin treatment significantly decreased blood Pb. On postnatal day 21, the number of degenerating Purkinje cells was remarkably increased while the number of calbindin-, GAD67-, NMDAR1-, LPAR1-immunoreactive intact Purkinje cells, and GABA transporter 1-immunoreactive pinceau structures were significantly reduced in Pb-exposed offspring. Following Pb exposure, gintonin ameliorated cerebellar degenerative effects, restored increased pro-apoptotic Bax, and decreased anti-apoptotic Bcl2. Gintonin treatment attenuated Pb-induced accumulation of oxidative stress (Nrf2 and Mn-SOD) and inflammation (IL-1β and TNFα,), restoring the decreased cerebellar BDNF and Sirt1. Gintonin ameliorated Pb-induced impairment of myelin basic protein-immunoreactive myelinated fibers of Purkinje cells. Gintonin attenuated Pb-induced locomotor dysfunctions. The present study revealed the ameliorating effects of gintonin against Pb, suggesting the potential use of gintonin as a preventive agent in Pb poisoning during pregnancy and lactation.

scholarly journals Protective Effects of Dietary Spirulina platensis against Cadmium-Induced Oxidative Stress in Gills of Rainbow Trout

2017 ◽  
Vol 11 (4) ◽  
pp. 5-12 ◽  
Author(s):  
Hamid Evaz-Zadeh Samani ◽  
Mahdi Banaee ◽  
Parvaneh Shoukat ◽  
Ahmad Noori ◽  
Laleh Mousavi Dehmoredi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rainbow Trout ◽  
Spirulina Platensis ◽  
Protective Effects
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