scholarly journals Clinical Validity of Subjective Clinical Prognosis in First Episode Psychosis Schizophrenia Patients: An Analysis of Data from the European First Episode Schizophrenia Trial (EUFEST) Study

2020 ◽  
Vol Volume 16 ◽  
pp. 1279-1284
Author(s):  
Valentin Petre Matei ◽  
Alexandra Ioana Mihăilescu ◽  
Iuliana Raluca Gheorghe ◽  
Ruxandra Grigoraş ◽  
Andrei Crasan ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Clinical Validity ◽  
Clinical Prognosis ◽  
Episode Psychosis ◽  
First Episode Schizophrenia

scholarly journals Treatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naïve patients with psychosis

2019 ◽  
Vol 50 (13) ◽  
pp. 2182-2193 ◽  
Author(s):  
Kirsten B. Bojesen ◽  
Bjørn H. Ebdrup ◽  
Kasper Jessen ◽  
Anne Sigvard ◽  
Karen Tangmose ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Poor Response ◽  
First Episode Psychosis ◽  
Anterior Cingulate ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Resonance Spectroscopy ◽  
Reference Levels ◽  
Clinical Prognosis ◽  
Episode Psychosis

AbstractBackgroundPoor response to dopaminergic antipsychotics constitutes a major challenge in the treatment of psychotic disorders and markers for non-response during first-episode are warranted. Previous studies have found increased levels of glutamate and γ-aminobutyric acid (GABA) in non-responding first-episode patients compared to responders, but it is unknown if non-responders can be identified using reference levels from healthy controls (HCs).MethodsThirty-nine antipsychotic-naïve patients with first-episode psychosis and 36 matched HCs underwent repeated assessments with the Positive and Negative Syndrome Scale and 3T magnetic resonance spectroscopy. Glutamate scaled to total creatine (/Cr) was measured in the anterior cingulate cortex (ACC) and left thalamus, and levels of GABA/Cr were measured in ACC. After 6 weeks, we re-examined 32 patients on aripiprazole monotherapy and 35 HCs, and after 26 weeks we re-examined 30 patients on naturalistic antipsychotic treatment and 32 HCs. The Andreasen criteria defined non-response.ResultsBefore treatment, thalamic glutamate/Cr was higher in the whole group of patients but levels normalized after treatment. ACC levels of glutamate/Cr and GABA/Cr were lower at all assessments and unaffected by treatment. When compared with HCs, non-responders at week 6 (19 patients) and week 26 (16 patients) had higher baseline glutamate/Cr in the thalamus. Moreover, non-responders at 26 weeks had lower baseline GABA/Cr in ACC. Baseline levels in responders and HCs did not differ.ConclusionGlutamatergic and GABAergic abnormalities in antipsychotic-naïve patients appear driven by non-responders to antipsychotic treatment. If replicated, normative reference levels for glutamate and GABA may aid estimation of clinical prognosis in first-episode psychosis patients.

P.3.f.004 Roots to clinical prognosis in first episode psychosis of schizophrenia data from EUFEST study

2015 ◽  
Vol 25 ◽  
pp. S538
Author(s):  
V. Matei ◽  
R. Al-Bataineh ◽  
A. Mihailescu ◽  
T. Purnichi ◽  
A. Crasan
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Clinical Prognosis ◽  
Episode Psychosis

scholarly journals Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis

2013 ◽  
Vol 43 (12) ◽  
pp. 2571-2582 ◽  
Author(s):  
A. Riecher-Rössler ◽  
J. K. Rybakowski ◽  
M. O. Pflueger ◽  
R. Beyrau ◽  
R. S. Kahn ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Antipsychotic Medication ◽  
Dopamine Release ◽  
First Episode Psychosis ◽  
Feedback Mechanism ◽  
Serum Prolactin ◽  
First Episode ◽  
Reference Standard ◽  
Episode Psychosis ◽  
First Episode Schizophrenia

BackgroundHyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs).MethodIn the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500.ResultsTwenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men.ConclusionsHyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.

scholarly journals Rational pharmacotherapy in early psychosis

2005 ◽  
Vol 187 (S48) ◽  
pp. s77-s84 ◽  
Author(s):  
Gary Remington
Keyword(s):  
First Episode Psychosis ◽  
Early Psychosis ◽  
First Episode ◽  
Rational Pharmacotherapy ◽  
Episode Psychosis ◽  
Growing Body ◽  
Detection And Diagnosis ◽  
First Episode Schizophrenia ◽  
Early Detection And Diagnosis ◽  
Dosing Patterns

BackgroundAn increased focus in research specific to first-episode schizophrenia has provided a rapidly growing body of evidence that can be directly translated to clinical practice.AimsTo provide clinical recommendations specific to effective pharmacotherapy of first-episode schizophrenia.MethodEvidence from clinical trials focused on the first-episode population is combined with data from other areas of investigation.ResultsIn first-episode psychosis, when to initiate treatment is not always clear, being intimately linked to challenges regarding early detection and diagnosis. There may be differences in antipsychotic dosing, patterns of response and sensitivity to side-effects. Adherence appears to be even more problematic at this stage.ConclusionsClinicians currently treating early psychosis have considerably more information to guide their decision-making. However, the speed at which the field is growing is a reminder totreatthis knowledge as a work in progress.

Psychopathology of first-episode psychosis in HIV-positive persons in comparison to first-episode schizophrenia: A neglected issue

AIDS Care ◽  
2006 ◽  
Vol 18 (8) ◽  
pp. 872-878 ◽  
Author(s):  
D. De Ronchi ◽  
F. Bellini ◽  
G. Cremante ◽  
M. Ujkaj ◽  
I. Tarricone ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Hiv Positive ◽  
Episode Psychosis ◽  
First Episode Schizophrenia

Gender differences in response to metacognitive training in people with first-episode psychosis.

2020 ◽  
Vol 88 (6) ◽  
pp. 516-525 ◽  
Author(s):  
Miriam Salas-Sender ◽  
Raquel López-Carrilero ◽  
Ana Barajas ◽  
Esther Lorente-Rovira ◽  
Esther Pousa ◽  
...  
Keyword(s):  
Gender Differences ◽  
First Episode Psychosis ◽  
First Episode ◽  
Metacognitive Training ◽  
Episode Psychosis

Cognitive clusters in first-episode psychosis: Overlap with healthy controls and relationship to concurrent and prospective symptoms and functioning.

2017 ◽  
Vol 31 (7) ◽  
pp. 787-797 ◽  
Author(s):  
Jacqueline Uren ◽  
Susan M. Cotton ◽  
Eoin Killackey ◽  
Michael M. Saling ◽  
Kelly Allott
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Healthy Controls ◽  
Episode Psychosis

Improving outcomes: Factors influencing help-seeking behaviors in immigrants and ethnic minorities with first-episode psychosis

2016 ◽  
Vol 13 (03) ◽  
pp. 152-157
Author(s):  
A. O. Berg ◽  
K. Leopold ◽  
S. Zarafonitis-Müller ◽  
M. Nerhus ◽  
L. H. Stouten ◽  
...  
Keyword(s):  
Mental Health ◽  
Help Seeking ◽  
Service Use ◽  
First Episode Psychosis ◽  
Pathways To Care ◽  
First Episode ◽  
Factors Influencing ◽  
Increased Risk ◽  
Episode Psychosis ◽  
The Hague

Summary Background: Immigrants have increased risk of a poor recovery from first episode psychosis (FEP). Early treatment can improve prognosis, but having an immigrant background may influence pathways to care. Method: We present research of service use and factors influencing treatment outcome in immigrants with FEP. Service use was assessed in in-patients at an early intervention center in Berlin, Germany. Duration of untreated psychosis and beliefs about illness was assessed in a FEP study in Oslo, Norway and cognitive functioning in patients with FEP schizophrenia from the regular mental health services in The Hague, the Netherlands. The proportion of immigrants in Berlin and Oslo was at level with the local populations, while the proportion in The Hague appeared to be higher. Result: There were clear indications that mental health literacy, probably based in different cultural expectations, were lower in first generation immigrants (FGI). Findings regarding clinical insight were ambiguous. There were also indications that FGI had more cognitive problems, based in higher stress levels or in cognitive styles. Early psychosis services must take issues of immigration and ethnicity into consideration.

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