scholarly journals Cornel Iridoid Glycoside Protects Against White Matter Lesions Induced by Cerebral Ischemia in Rats via Activation of the Brain-Derived Neurotrophic Factor/Neuregulin-1 Pathway

2019 ◽  
Vol Volume 15 ◽  
pp. 3327-3340 ◽  
Author(s):  
Mingyang Wang ◽  
Xuesi Hua ◽  
Hongmei Niu ◽  
Zhengyu Sun ◽  
Li Zhang ◽  
...  
Keyword(s):  
White Matter ◽  
Cerebral Ischemia ◽  
Neurotrophic Factor ◽  
White Matter Lesions ◽  
Brain Derived Neurotrophic Factor ◽  
Iridoid Glycoside ◽  
Neuregulin 1 ◽  
Cornel Iridoid Glycoside ◽  
The Brain

scholarly journals Stroke Damage in Mice after Knocking the Neutrophin-4 Gene into the Brain-Derived Neurotrophic Factor Locus

2003 ◽  
Vol 23 (2) ◽  
pp. 150-153 ◽  
Author(s):  
Matthias Endres ◽  
Guoping Fan ◽  
Lorenz Hirt ◽  
Rudolf Jaenisch
Keyword(s):  
Cerebral Ischemia ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Protective Role ◽  
Artery Occlusion ◽  
Physiologic Parameters ◽  
Single Allele ◽  
Cerebral Artery Occlusion ◽  
The Brain ◽  
Increased Susceptibility

Neurotrophins play a protective role during cerebral ischemia, and mice lacking both alleles for neurotrophin 4 (Nt4−/-) or deficient in a single allele for brain-derived neurotrophic factor (Bdnf−/-) have increased susceptibility to cerebral ischemia. This study directly compared the biologic activities of brain-derived neurotrophic factor (BDNF) and NT4 by replacing the Bdnf coding sequence with the Nt4 sequence (Bdnf+/nt4–ki). Mice expressing one Nt4 allele in place of Bdnf develop 61% bigger lesions after 1-hour middle cerebral artery occlusion compared with wild-type littermates. Physiologic parameters did not contribute to ischemia susceptibility. In conclusion, NT4 is less potent than BDNF in promoting brain survival after stroke.

scholarly journals What does the water inside the brain tell us? Diffusion tensor imaging

2018 ◽  
Vol 2 (4) ◽  
pp. 177-179
Author(s):  
Niyazi Acer ◽  
Mehmet Sait Dundar ◽  
Serap Bastepe-Gray
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cerebral Ischemia ◽  
Metabolic Disorders ◽  
Diffusion Tensor ◽  
Neurological Diseases ◽  
White Matter Lesions ◽  
The Brain ◽  
Diffusion Tensor Imaging Dti ◽  
Degenerating Axons

Abstract The brain consist of about 75 percent water. Diffusion tensor imaging (DTI) is an advanced magnetic resonance (MR) technique imaging that has been developed for diagnostic and research in medicine. It can be use DTI tractography to better understand degenerating axons of white matter lesions in some neurological diseases such as MS, AD, trauma, cerebral ischemia, epilepsy, brain tumors and metabolic disorders.

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