scholarly journals Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up

2019 ◽  
Vol Volume 15 ◽  
pp. 3247-3254
Author(s):  
Krzysztof Kucia ◽  
Wojciech Merk ◽  
Krzysztof Zapalowicz ◽  
Tomasz Medrala
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Case Series ◽  
Efficacy And Safety ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression ◽  
One Year

Vagus Nerve Stimulation Therapy in a Patient with Treatment-Resistant Depression: A Case Report of Long-Term Follow-up and Battery End-of-Service

CNS Spectrums ◽  
2006 ◽  
Vol 11 (2) ◽  
pp. 143-148 ◽  
Author(s):  
James M. Martinez ◽  
Holly A. Zboyan
Keyword(s):  
Case Report ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Long Term Follow Up ◽  
Resistant Depression

AbstractThis is the first case report of a patient who received long-term (69-month) adjunctive vagus nerve stimulation (VNS) therapy for treatment-resistant depression (TRD) and reached VNS battery end-of-service (EOS).The patient is a 41-year-old female with depression who entered a study of adjunctive VNS therapy for TRD. Her Hamilton Rating Scale for Depression (HAM-D) scores dropped from a mean of 33.5 (pre-implantation baseline period) to 16 at the end of the 12-week acute-phase treatment period, and then fluctuated from <7 (normal range) to scores in the moderately depressed range (∼20) during long-term follow-up. Three and one-half years after VNS implantation, the patient's HAM-D scores began to increase from a score of 18 to a peak score of 27 ∼ 16 months later (5-years post-implantation). The patient subsequently reported that she could no longer feel stimulation from the device and device interrogation 2 weeks later indicated battery EOS. The patient was hospitalized due to worsened depression, the pulse generator was replaced, and medication adjusted. HAM-D scores through the subsequent 9 months of followup returned to a pattern of fluctuations within the range noted during the long-term follow-up period prior to VNS battery EOS.

scholarly journals Vagus Nerve Stimulation in Treatment-Resistant Depression: Long-term Clinical Outcomes

2021 ◽  
Author(s):  
Stella Rosson ◽  
Nicola Bresolin ◽  
Domenico d’Avella ◽  
Luca Denaro ◽  
Alessandro Landi ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Case Series ◽  
University Hospital ◽  
Psychiatric Disease ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

I ntroduction Vagus nerve stimulation (VNS) is a neuromodulation technique approved for Treatment-Resistant Depression (TRD).Evidence regarding its long-term efficacy and safety is still scarce. Objectives To descriptively report a case series of 3 patients undergoing adjunctive VNS for TRD with an over 10-year follow-up. Methods We investigated outcomes of clinical interest in patients with ongoing VNS for at least 10 years after the device implantation. They had participated in a larger single-arm interventional study conducted at the University Hospital of Padua. They were diagnosed with chronic unipolar (1), recurrent unipolar (1), and bipolar (1) TRD. Results Our 3 cases had an average 14-year history of psychiatric disease before surgery. Afterward, all subjects achieved clinical remission within two years. 2 patients experienced relapses within the first 4 years of treatment (respectively, 1 and 2 episodes). The other case showed a recurrent trend of brief relapses every two years. Only 1 individual needed to be admitted to the psychiatric unit once. None of them committed suicidal attempts. Prescription of antidepressants remained almost unchanged after the first two years. 2 individuals improved and 1 maintained their working position. Common adverse events were voice alteration (3/3), neck pain (2/3), and cough (2/3). Conclusions Very few cases of 10-year VNS for TRD have been reported so far. For our subjects, VNS was most likely to have a major impact on the clinical course of the disease. This treatment can be a safe and effective adjunctive intervention in a subgroup of patients with TRD.

A One-Year Comparison of Vagus Nerve Stimulation with Treatment as Usual for Treatment-Resistant Depression

2005 ◽  
Vol 58 (5) ◽  
pp. 364-373 ◽  
Author(s):  
Mark S. George ◽  
A. John Rush ◽  
Lauren B. Marangell ◽  
Harold A. Sackeim ◽  
Stephen K. Brannan ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Treatment As Usual ◽  
Resistant Depression ◽  
One Year

A 6-Year Follow-up Study of Vagus Nerve Stimulation Effect on Quality of Life in Treatment-Resistant Depression

2018 ◽  
Vol 34 (4) ◽  
pp. e58-e60 ◽  
Author(s):  
François Trottier-Duclos ◽  
Véronique Desbeaumes Jodoin ◽  
Marie-Pierre Fournier-Gosselin ◽  
François Richer ◽  
Nathalie Desjardins ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Follow Up Study ◽  
Resistant Depression

scholarly journals Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression

2019 ◽  
Vol Volume 15 ◽  
pp. 457-468 ◽  
Author(s):  
Arun Kumar ◽  
Mark T Bunker ◽  
Scott T Aaronson ◽  
Charles R Conway ◽  
Anthony J Rothschild ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

Vagus Nerve Stimulation in Treatment-Resistant Depression

2013 ◽  
Vol 29 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Lucio Oldani ◽  
M. Carlotta Palazzo ◽  
Ilaria Balossi ◽  
Mariateresa Ciabatti ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

Possibilities of vagus nerve stimulation in treatment resistant depression - preliminary report

2012 ◽  
Vol 24 (2) ◽  
pp. 184
Author(s):  
J. Chrastina⁎ ◽  
Z. Novak ◽  
T. Kasparek ◽  
E. Cesková ◽  
R. Prikryl ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Preliminary Report ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression
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