scholarly journals Vitamin D3 as adjunctive therapy in the treatment of depression in tuberculosis patients: a short-term pilot randomized double-blind controlled study

2018 ◽  
Vol Volume 14 ◽  
pp. 3103-3109 ◽  
Author(s):  
Li Zhang ◽  
Shanshan Wang ◽  
Yuyin Zhu ◽  
Tianchi Yang
Keyword(s):  
Vitamin D3 ◽  
Adjunctive Therapy ◽  
Controlled Study ◽  
Short Term ◽  
Double Blind ◽  
Tuberculosis Patients ◽  
Treatment Of Depression

Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

2017 ◽  
Vol 31 (10) ◽  
pp. 1374-1376
Author(s):  
Jack H Wilson ◽  
Amy H Criss ◽  
Sean A Spangler ◽  
Katherine Walukevich ◽  
Sandra Hewett
Keyword(s):  
Young Adults ◽  
Healthy Adult ◽  
Adult Population ◽  
Critical Role ◽  
Random Order ◽  
Controlled Study ◽  
High Dose ◽  
Short Term ◽  
Double Blind ◽  
Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

scholarly journals Rituximab vs placebo induction prior to glatiramer acetate monotherapy in multiple sclerosis

Neurology ◽  
2019 ◽  
Vol 92 (7) ◽  
pp. e723-e732 ◽  
Author(s):  
Justin M. Honce ◽  
Kavita V. Nair ◽  
Stefan Sillau ◽  
Brooke Valdez ◽  
Augusto Miravalle ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Glatiramer Acetate ◽  
Controlled Study ◽  
Short Term ◽  
Double Blind ◽  
T2 Lesions ◽  
Time To Treatment Failure ◽  
Sustained Change ◽  
Baseline Characteristics ◽  
Relapsing Multiple Sclerosis

ObjectiveTo examine whether rituximab induction followed by glatiramer acetate (GA) monotherapy is more effective than GA alone for the treatment of relapsing multiple sclerosis with active disease.MethodsThis was a single-center, double-blind, placebo-controlled study. Fifty-five participants were randomly assigned (1:1 ratio) to either rituximab (R-GA) or placebo (P-GA) induction, followed by GA therapy initiated in all participants. Participants were followed up to 3 years. The primary endpoint was the number of participants with no evidence of disease activity (NEDA): those without relapse, new MRI lesions, and sustained change in disability.ResultsTwenty-eight and 27 participants received rituximab and placebo induction, respectively, with one participant in each arm withdrawing before 6-month MRI. There were no significant differences in baseline characteristics. At end of study, 44.44% of R-GA participants demonstrated NEDA vs 19.23% of P-GA participants (p = 0.049). Treatment failed for a smaller proportion of R-GA participants (37.04% R-GA vs 69.23% P-GA, p = 0.019), and time to treatment failure was longer (23.32 months R-GA vs 11.29 months P-GA, p = 0.027). Fewer participants in the R-GA arm had new lesions (25.93% R-GA vs 61.54% P-GA, p = 0.009), and there were fewer new T2 lesions (0.48 R-GA vs 1.96 P-GA, p = 0.027). Probability of demonstrating NEDA in the R-GA arm returned to baseline within the study period. There were no differences in adverse events.ConclusionsInduction therapy with rituximab followed by GA may provide superior efficacy in the short term than GA alone in relapsing multiple sclerosis, but this benefit appears to wane within the study period. Larger studies are needed to assess sustainability of results.ClinicalTrials.gov identifierNCT01569451.

Short-Term Augmentation of Fluoxetine With Clonazepam in the Treatment of Depression: A Double-Blind Study

1998 ◽  
Vol 155 (10) ◽  
pp. 1339-1345 ◽  
Author(s):  
Ward T. Smith ◽  
Peter D. Londborg ◽  
Vincent Glaudin ◽  
John R. Painter
Keyword(s):  
Blind Study ◽  
Double Blind Study ◽  
Short Term ◽  
Double Blind ◽  
Treatment Of Depression
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